Breast cancer and aging: Standing on the shoulders of a giant

Karuturi, Meghan Sri; Sedrak, Mina S.; Magnuson, Allison; Freedman, Rachel A.; Jatoi, Aminah; Smith, Blaine D.; Kimmick, Gretchen

doi:10.1016/j.jgo.2019.05.019

Cited by 3 publications

(3 citation statements)

References 19 publications

(19 reference statements)

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“…Results showed that the earlier in life these two events occur, the lower the risk of developing BCa. Moreover, aging is another natural event that has been deeply associated with breast cancer [ 31 ]. We observed a significant difference between the two groups, further supporting that BCa is associated with aging.…”

Section: Resultsmentioning

confidence: 99%

Altered Expression of Survivin Variants S-2B and S-WT in Breast Cancer Is Related to Adipokine Expression

Cedano-Prieto

Bergez-Hernández

Leal-León

et al. 2022

Journal of Oncology

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Breast cancer (BCa) is one of the leading causes of death in women with these types of malignancies. Early detection is pivotal to improve prognosis and reduce mortality. Several proteins and genes have been proposed as biomarkers for cancer; however, further studies are required before a molecule is accepted as a definitive biomarker. This study was aimed at investigating the expression of survivin variants S-WT, S-2B, and S-ΔEx3, as well as adipokines LEP and ADIPOQ in breast cancer. Breast samples were obtained from patients with ( n = 27 ) and without ( n = 20 ) BCa, and relative gene expression was assessed by RT-qPCR. S-WT and S-2B showed a significant increase in BCa samples ( p = 0.005 and p = 0.001 , respectively) and in high-aggressiveness BCa ( p = 0.026 and p = 0.037 , respectively). Despite S-ΔEx3 expression remained globally unchanged, when dividing BCa samples according to the stage, this gene showed a significant tendency to increase towards more advanced stages, and the exact opposite effect was observed for LEP. Furthermore, LEP expression showed a negative correlation with S-2B ( p = 0.005 ) and S-WT ( p = 0.011 ), and in the same manner, ADIPOQ was negatively related with these two survivin variants ( p = 0.001 and p = 0.005 , respectively). Interestingly, S-ΔEx3 expression appears unaffected by LEP and ADIPOQ expressions. Our results highlight the importance of investigating specific variants of a given gene, as sequence variation may grant different correlation with other important structures and diseases.

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Section: Resultsmentioning

confidence: 99%

Altered Expression of Survivin Variants S-2B and S-WT in Breast Cancer Is Related to Adipokine Expression

Cedano-Prieto

Bergez-Hernández

Leal-León

et al. 2022

Journal of Oncology

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“…The current shift in the characteristics of cancer incidence and mortality in China reminisces what happened in the United States. Although with the pressures of population aging (Karuturi et al, 2020), environmental pollution (White et al, 2021), and bad living habits (Kolb et al, 2016), the incidence and mortality rates of some cancers in the United States continue to decline, which is largely attributed to the devoted basic cancer research, efficient cancer prevention and treatment innovations in the United States. This suggests that China can refer to the measures taken by the United States on cancer prevention and treatment to come up with realistic solutions complying with the current situation of an aging population and challenging environmental problems in China to effectively reduce the cancer burden on society (Xia et al, 2022).…”

Section: Cancer Spectrum In China Is Shifting Towards That In Develop...mentioning

confidence: 99%

Overview and countermeasures of cancer burden in China

Wang

Yan

et al. 2023

Sci. China Life Sci.

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Cancer is one of the leading causes of human death worldwide. Treatment of cancer exhausts significant medical resources, and the morbidity and mortality caused by cancer is a huge social burden. Cancer has therefore become a serious economic and social problem shared globally. As an increasingly prevalent disease in China, cancer is a huge challenge for the country’s healthcare system. Based on recent data published in the Journal of the National Cancer Center on cancer incidence and mortality in China in 2016, we analyzed the current trends in cancer incidence and changes in cancer mortality and survival rate in China. And also, we examined several key risk factors for cancer pathogenesis and discussed potential countermeasures for cancer prevention and treatment in China.

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“…Compared with other countries, for example, the United States, in which the median diagnosed age of breast cancer is more than 60 years ( 4 ), in China, breast cancer occurs at a younger age in women, with the median age at diagnosis of 48–50 years ( 5 – 7 ). Breast cancer in China is with more frequent advanced-stage presentation ( 6 ), and there are regional variations in incidence ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

A Cross-Sectional Study of Breast Cancer Surgery and the Cost Based on Data From 77 Chinese 3A Hospitals in 2015

et al. 2022

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PurposesWe aimed to clarify the real-world status of breast cancer surgery and the cost in China.MethodsThis cross-sectional survey relied on data obtained from the hospitalization summary reports (HSRs) in 77 top-ranked (grade 3A) hospitals in China to analyze breast cancer patients who underwent surgery between January 2015 and December 2015. The surgery and cost were mainly evaluated.ResultsOverall, 31,900 breast cancer patients underwent surgeries in 77 hospitals. The mean age in our study was 51.5 years (SD, 11.7 years). The primary types of surgical procedures were mastectomy (n = 24,629, 77.2%) and breast-conserving surgery (6,210, 19.5%). The rate of mastectomy was the highest at age band 50–65 years (n = 10,861, 82.1%) and in non-first-tier cities (n = 7,651, 88.4%) as well as in Northeast China (n = 3,107, 93.2%). The rate of breast-conserving surgery was less than 10% in non-first-tier cities (9.8%), Southwest China (6.1%), and Northeast China (5.8%). The median cost was $3,352.4 (interquartile range (IQR), $2,492.6–4,588.0). Mastectomy cost was significantly higher than breast-conserving surgery cost in both different city tiers and regional distribution except Northeast China (p < 0.001).ConclusionsThis study demonstrated that the main breast cancer surgery in Chinese 3A hospitals was mastectomy and that the cost varied both across and within geographic regions and city tiers. This information helps describe the real-world status of breast surgery and the cost in China.

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Breast cancer and aging: Standing on the shoulders of a giant

Cited by 3 publications

References 19 publications

Altered Expression of Survivin Variants S-2B and S-WT in Breast Cancer Is Related to Adipokine Expression

Altered Expression of Survivin Variants S-2B and S-WT in Breast Cancer Is Related to Adipokine Expression

Overview and countermeasures of cancer burden in China

A Cross-Sectional Study of Breast Cancer Surgery and the Cost Based on Data From 77 Chinese 3A Hospitals in 2015

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