Breast cancer among HIV-infected patients: The experience of the European Institute of Oncology

Intra, Mattia; Gentilini, Oreste; Brenelli, Fabrício; Chagas, E.; Veronesi, Umberto; Sandri, Maria Teresa

doi:10.1002/jso.20315

Cited by 17 publications

(16 citation statements)

References 11 publications

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“…Other reports suggested that immunosuppression might be a protective factor against the development of breast cancer in HIV-positive patients. 6,7 The average number of years with HIV infection we report here (8.8 years) warrants discussion about the potential relationship between long-standing HIV presence and the development of breast cancer.…”

Section: Discussionmentioning

confidence: 87%

“…Given that the incidence of breast cancer in Louisiana is 115.7 per 100 000 patients, 17 the frequency of breast cancer in our population is low (taking into account the fact that we retrospectively reviewed charts from 2002 to 2010). 6,13,18,19 Potential reasons to explain this finding could be underreporting, misclassification, and truly low frequency of breast cancer.…”

Section: Discussionmentioning

confidence: 89%

“…Some reports suggest a decreased frequency of breast cancer among HIV populations while others report the contrary. 6,7 Reports suggest that HIV-positive patients present with breast cancer at earlier age than do non-HIV-infected patients. In addition, their cancers are more aggressive, are less responsive to treatment cancer, are more metastatic, and develop more side effects to chemotherapy treatments.…”

Section: Introductionmentioning

confidence: 97%

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Breast Cancer in HIV-Infected Patients: A Retrospective Single-Institution Study

Ruiz

Davis

2011

Journal of the International Association of Physicians in AIDS

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 97%

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Breast Cancer in HIV-Infected Patients: A Retrospective Single-Institution Study

Ruiz

Davis

2011

Journal of the International Association of Physicians in AIDS

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“…4,5 In developed countries, BC may be slightly less common among HIV-infected than HIV-uninfected women or the general population 6–10 because reproductive factors associated with HIV infection, such as young age at first pregnancy and multiple pregnancies, are associated with reduced risk of BC. In southern Africa, however, HIV may be associated with lower parity.…”

Section: Introductionmentioning

confidence: 99%

South African Breast Cancer and HIV Outcomes Study: Methods and Baseline Assessment

Cubasch

Ruff

Joffe

et al. 2017

JGO

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Purpose In low- and middle-income, HIV-endemic regions of sub-Saharan Africa, morbidity and mortality from the common epithelial cancers of the developed world are rising. Even among HIV-infected individuals, access to antiretroviral therapy has enhanced life expectancy, shifting the distribution of cancer diagnoses toward non–AIDS-defining malignancies, including breast cancer. Building on our prior research, we recently initiated the South African Breast Cancer and HIV Outcomes study. Methods We will recruit a cohort of 3,000 women newly diagnosed with breast cancer at hospitals in high (average, 20%) HIV prevalence areas, in Johannesburg, Durban, Pietermaritzburg, and Empangeni. At baseline, we will collect information on demographic, behavioral, clinical, and other factors related to access to health care. Every 3 months in year 1 and every 6 months thereafter, we will collect interview and chart data on treatment, symptoms, cancer progression, comorbidities, and other factors. We will compare survival rates of HIV-infected and uninfected women with newly diagnosed breast cancer and their likelihood of receiving suboptimal anticancer therapy. We will identify determinants of suboptimal therapy and context-specific modifiable factors that future interventions can target to improve outcomes. We will explore molecular mechanisms underlying potentially aggressive breast cancer in both HIV-infected and uninfected patients, as well as the roles of pathogens, states of immune activation, and inflammation in disease progression. Conclusion Our goals are to contribute to development of evidence-based guidelines for the management of breast cancer in HIV-positive women and to improve outcomes for all patients with breast cancer in resource-constrained settings.

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“…Although HIV infection directly and indirectly affects breast tissue, the incidence of breast cancer appears not to be increased in WLWH. Indeed, several large studies have reported a slightly lower incidence of breast cancer compared to the general population [72–74]. The age at breast cancer diagnosis is similar in WLWH and the general population, after age adjustment for at-risk populations [75], and screening for breast cancer should follow standard, age-appropriate screening recommendations that apply to the general population.…”

Section: Gender Differences and Women-specific Issues In Hiv And Its mentioning

confidence: 99%

Caring for women living with HIV: gaps in the evidence

Loutfy

Sherr

Sonnenberg-Schwan³

et al. 2013

Journal of the International AIDS Society

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IntroductionIn the management of HIV, women and men generally undergo the same treatment pathway, with gender differences being given limited consideration. This is in spite of accumulating evidence that there are a number of potential differences between women and men which may affect response to treatment, pharmacokinetics, toxicities and coping. There are also notable psychological, behavioural, social and structural factors that may have a unique impact on women living with HIV (WLWH). Despite our increasing knowledge of HIV and advances in treatment, there are significant gaps in the data relating specifically to women. One of the factors contributing to this situation is the under-representation of women in all aspects of HIV clinical research. Furthermore, there are clinical issues unique to women, including gynaecologic and breast diseases, menopause-related factors, contraception and other topics related to women's and sexual health.MethodsUsing scoping review methodology, articles from the literature from 1980 to 2012 were identified using appropriate MeSH headings reflecting the clinical status of WLWH, particularly in the areas of clinical management, sexual health, emotional wellbeing and treatment access. Titles and abstracts were scanned to determine whether they were relevant to non-reproductive health in WLWH, and papers meeting inclusion criteria were reviewed.ResultsThis review summarizes our current knowledge of the clinical status of WLWH, particularly in the areas of clinical management, sexual health, emotional wellbeing and treatment access. It suggests that there are a number of gender differences in disease and treatment outcomes, and distinct women-specific issues, such as menopause and co-morbidities, that pose significant challenges to the care of WLWH.ConclusionsBased on a review of this evidence, outstanding questions and areas where further studies are required to determine gender differences in the efficacy and safety of treatment and other clinical and psychological issues specifically affecting WLWH have been identified. Well-controlled and adequately powered clinical studies are essential to help provide answers to these questions and to contribute to activities aimed at improving the health and wellbeing of WLWH.

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Breast cancer among HIV-infected patients: The experience of the European Institute of Oncology

Cited by 17 publications

References 11 publications

Breast Cancer in HIV-Infected Patients: A Retrospective Single-Institution Study

Breast Cancer in HIV-Infected Patients: A Retrospective Single-Institution Study

South African Breast Cancer and HIV Outcomes Study: Methods and Baseline Assessment

Caring for women living with HIV: gaps in the evidence

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