Breast Cancer

Hankinson, Susan E.; Tamimi, Rulla M.; Hunter, David

doi:10.1093/acprof:oso/9780195311174.003.0016

Cited by 45 publications

(64 citation statements)

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“…Family history of breast cancer is an established risk factor for breast cancer [1]. Twin studies indicate that inherited genetic influences account for approximately 27% of the variation in breast cancer risk [2].…”

Section: Introductionmentioning

confidence: 99%

Birth weight, breast cancer susceptibility loci, and breast cancer risk

Tamimi

Λάγιου

Czene

et al. 2010

Cancer Causes Control

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Section: Introductionmentioning

confidence: 99%

Birth weight, breast cancer susceptibility loci, and breast cancer risk

Tamimi

Λάγιου

Czene

et al. 2010

Cancer Causes Control

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“…Important causes are genetic defects, reproductive factors, alcohol, overweight, and physical inactivity, but these factors do not account for the total number of incident breast cancer cases [2]. Moreover, risk factors differ according to estrogen receptor (ER) and progesterone receptor (PR) status of the tumors [3], underscoring the importance of stratifying on receptor status when investigating breast cancer etiology.…”

Section: Introductionmentioning

confidence: 99%

Dietary acrylamide intake and estrogen and progesterone receptor-defined postmenopausal breast cancer risk

Pedersen

Hogervorst

Schouten

et al. 2009

Breast Cancer Res Treat

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Acrylamide, a potential human carcinogen, has been discovered in a variety of heat-treated carbohydraterich food products. Previously, dietary acrylamide intake was shown to be associated with endocrine-related cancers in humans. We assessed the association between dietary acrylamide intake and risk of postmenopausal breast cancer stratified by estrogen and progesterone receptor status. This study was embedded within the Netherlands Cohort Study on diet and cancer, which was initiated in 1986 enrolling 62,573 women aged 55-69 years at baseline. After 13.3 years of follow-up, 2225 incident breast cancer cases were ascertained, with hormone receptor status information for 43%. Cox proportional hazards analysis was applied to determine hazard ratios in quintiles of dietary acrylamide intake stratifying on estrogen receptor (ER) and progesterone receptor (PR) and smoking status. No association was observed for overall breast cancer or receptor-negative breast cancer risk, irrespective of smoking status. A statistically non-significantly increased risk of ER positive, PR positive and joint receptor-positive breast cancer was found in never-smoking women. The multivariable-adjusted hazard ratios were 1.31 (95% CI: 0.87-1.97, P trend = 0.26) for ER?, 1.47 (0.86-2.51, P trend = 0.14) for PR?, and 1.43 (0.83-2.46, P trend = 0.16) for ER?PR?, when comparing women in the highest quintile of acrylamide intake (median 36.8 lg/day) to women in the lowest (median 9.5 lg/day). This study showed some indications of a positive association between dietary acrylamide intake and receptor-positive breast cancer risk in postmenopausal never-smoking women. Further studies are needed to confirm or refute our observations.

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“…Birth weight can, especially when adjusted for gestational age, be considered a proxy for fetal growth. As such, birth weight may be used as an indirect marker for fetal exposure to growthstimulating factors such as insulin-like growth factors (4)(5)(6) and estrogens (7)(8)(9), which may also be involved in the carcinogenesis of reproductive cancer diseases (10,11). High birth weight is associated with breast cancer (12), whereas the association between birth weight and prostate cancer is less certain (13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

Birth Characteristics and Risk of Prostate Cancer: the Contribution of Genetic Factors

Cnattingius

Lundberg

Sandin

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Prostate cancer has a strong hereditary component, but it has been proposed that hormonal influences in utero may contribute to offspring risk. We investigated the associations between birth characteristics and the risk of prostate cancer in twins, and whether possible associations could be confounded by familial factors, such as shared environment and common genes. Methods: All like-sexed male twins in the Swedish Twin Registry, born from 1926 to 1958 and alive in 1973, were eligible. Data were obtained from birth records, and 11,420 male twins with reliable birth weight data were included in the final study population. Hazard ratios with 95% confidence intervals (CI) from Cox regression models were used to estimate associations between birth characteristics and risk of prostate cancer. Paired analysis was done

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Breast Cancer

Cited by 45 publications

References 0 publications

Birth weight, breast cancer susceptibility loci, and breast cancer risk

Birth weight, breast cancer susceptibility loci, and breast cancer risk

Dietary acrylamide intake and estrogen and progesterone receptor-defined postmenopausal breast cancer risk

Birth Characteristics and Risk of Prostate Cancer: the Contribution of Genetic Factors

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