Breast Calciphylaxis Following Coronary Artery Bypass Grafting Completely Resolved with Total Parathyroidectomy

Campanino, Pier Paolo; Tota, Donatella; Bagnera, Silvia; Regini, E.; Taverna, G; Luparia, A.; Durando, Manuela; Mariscotti, Giovanna; Gandini, Giovanni

doi:10.1111/j.1524-4741.2010.00966.x

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…Mammographic findings include multiple and diffuse bilateral calcifications with dystrophic or vascular morphology13 and trabecular thickening indicative of parenchymal edema. 14 Ultrasonographic changes include tissue edema and shadowing foci suggestive of extensive macrocalcification 14.…”

Section: Vascular Diseasementioning

confidence: 99%

Breast manifestations of systemic diseases

Dilaveri

Bride

Sandhu

et al. 2012

IJWH

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Although much emphasis has been placed on the primary presentations of breast cancer, little focus has been placed on how systemic illnesses may affect the breast. In this article, we discuss systemic illnesses that can manifest in the breast. We summarize the clinical features, imaging, histopathology, and treatment recommendations for endocrine, vascular, systemic inflammatory, infectious, and hematologic diseases, as well as for the extramammary malignancies that can present in the breast. Despite the rarity of these manifestations of systemic disease, knowledge of these conditions is critical to the appropriate evaluation and treatment of patients presenting with breast symptoms.

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Section: Vascular Diseasementioning

confidence: 99%

Breast manifestations of systemic diseases

Dilaveri

Bride

Sandhu

et al. 2012

IJWH

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“… 5 6 There are rare case reports of mammary calciphylaxis occurring in patients post coronary artery bypass graft and on chemotherapy. 7 8 …”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis and Ulcerative Lesions of Bilateral Nipple–Areolar Complex Due to Alcoholic Liver Disease

Jha

Shrivastav

Kasyap

2022

Indian J Radiol Imaging

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When faced with eczematous lesions involving the nipple–areolar complex (NAC), Paget's disease is assumed to be the diagnosis, anything else being considered a “Zebra” necessitating its exclusion on pathology. A middle-aged lady presented with synchronous asymmetrical ulceration of bilateral NAC with pleomorphic calcifications on mammography and simultaneous extensive vascular calcification in bilateral breasts that suggested systemic cause. Calciphylaxis is a rare diagnosis occurring usually due to underlying end-stage renal disease or hyperparathyroidism. There are very few case reports of calciphylaxis due to alcoholic liver disease and no cases to the best of our knowledge involving NAC. We report an extremely rare case of breast and NAC calciphylaxis due to alcoholic liver disease, highlighting need to consider benign etiology when bilateral involvement is present.

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“…Induction of local hypercoagulability, involvement of regional inflammatory cytokines, lesional elevated bone morphogenetic protein-4 and osteopontin levels, and reactive oxygen species upregulating activators of nuclear transcription through loss of constituent inhibitors such as osteoprotegerin have also been linked to the development of calciphylaxis [ 17 – 19 ]. Of special relevance to practitioners of breast pathology are a few reported cases of mammary calciphylaxis following coronary artery bypass grafting and possible etiological roles of chemotherapy in promoting the development of calciphylaxis [ 20 – 22 ].…”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis of the Postmenopausal Female Breast: An Uncommonly Encountered Mimic of Carcinoma

Novotny

Simpson

Král

et al. 2017

Case Reports in Pathology

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Calciphylaxis is a serious medical condition that is typically associated with end-stage renal disease and presents as the sequelae of calcifications in arterioles with subsequent ischemia of affected tissues. Classically, calciphylaxis produces ulcerated and necrotic skin lesions. These may be biopsied to aid in confirmation of the diagnosis. Herein we report a case of a large necrotic breast lesion in the clinical setting of calciphylaxis, and we emphasize that a multidisciplinary approach to diagnosis and management is important to avoid unnecessary oncological resection.

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Breast Calciphylaxis Following Coronary Artery Bypass Grafting Completely Resolved with Total Parathyroidectomy

Cited by 8 publications

References 3 publications

Breast manifestations of systemic diseases

Breast manifestations of systemic diseases

Calciphylaxis and Ulcerative Lesions of Bilateral Nipple–Areolar Complex Due to Alcoholic Liver Disease

Calciphylaxis of the Postmenopausal Female Breast: An Uncommonly Encountered Mimic of Carcinoma

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