Breast arteries calcification: a potential surrogate marker for cerebrovascular disease

Bochkareva, E. V.; Butina, E. K.; Савин, А. С.; Stulin, I. D.; Trukhanov, S. A.; Drapkina, О. М.

doi:10.17116/profmed202023051164

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…В связи с этим важной практической задачей является поиск новых гендерспецифических маркеров, позволяющих улучшить стратификацию сердечно-сосудистого риска у женщин, среди которых одним из наиболее перспективных является кальциноз артерий молочной железы (КАМЖ), легко выявляемый при маммографии и ассоциирующийся с более высокой сердечно-сосудистой заболеваемостью и смерт ностью [4][5][6]. При маммографии наряду со структурными изменениями ткани молочной железы, в 10-15% случаев встречается КАМЖ [7], который с онкологической точки зрения расценивается как "доброкачественная находка", но одновременно с этим может указывать на высокую вероятность неблагоприятных сердечно-сосудистых событий.…”

Section: Introductionunclassified

“…Несмотря на значительное число работ, показавших более высокую частоту ишемического инсульта у женщин с КАМЖ [7], исследования по оценке ультразвуковых маркеров атеросклероза сонных артерий (СА) немногочисленны, предметом изучения чаще всего являлся показатель толщины комплекса интима-медиа (ТКИМ), и лишь в двух известных нам работах были исследованы каротидные атеро-склеротические бляшки (АСБ) в сочетании с КАМЖ [8,9]. Вместе с тем, именно наличие одной и более АСБ в СА по данным ультразвукового исследования, рассматривается сегодня не только как причина развития ишемического инсульта, но и как фактор, повышающий уровень сердечно-сосудистого риска в целом [10] в зависимости от числа, размера АСБ [11,12] и "атеросклеротической нагруженности" каротидного бассейна [13].…”

Section: Introductionunclassified

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Association of breast arterial calcification and carotid atherosclerosis as a marker of cardiovascular risk

Bochkareva,

Butina,

Bayramkulova

et al. 2023

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study the relationship between breast arterial calcification (BAC) and the presence and severity of carotid atherosclerosis.Material and methods. We analyzed 4274 digital mammograms of women who underwent diagnostic mammography. In addition to the standard diagnosis of breast diseases, BAC was assessed in all mammograms. The study included 198 women aged 40-74 years, who made up 2 groups with and without BAC, each consisting of 99 people, formed on a case-control basis. The severity of BAC was assessed by a 12-point score. Duplex ultrasound of extracranial arteries determined plaque presence, the severity of CA stenosis (in percent) and intima-media thickness (IMT). All women underwent physical and laboratory examinations, electrocardiography, and were interviewed using a questionnaire assessing socio-demographic data, menopausal status, risk factors, and diseases.Results. The groups did not differ in lipid levels, blood glucose, body mass index, incidence of hypertension, diabetes, or smoking. Women with BAC had a higher incidence of menopause (94,9% vs 84,8%, p=0,033), coronary artery disease (13,1% vs 4,2%, p=0,039) and osteoporosis (18,2% vs 6,1%, p=0,016) in history. In women with BAC, at least one carotid plaque was observed significantly more often than in those without BAC — in 79,8% and 60,6% of cases, respectively (p=0,005). Women with BAC compared with women without BAC had a greater plaque number (1,0 [1,0; 3,0] vs, 1,0 [1,0; 2,0], p<0,001) and a more severe carotid stenosis, assessed by maximum (25,0 [17,5; 35,0] vs 20,0 [0,0; 27,5], p=0,001), total (30,0 [20,0; 92,5] vs 25,0 [0,0; 50,0], p<0,001) and mean arterial stenosis (25,0 [17,5; 30,0] vs 20,0 [0,0; 25,0], p=0,001). For the first time, a positive relationship was revealed between the severity of carotid atherosclerosis and BAC as follows: women with greater severity of maximum and total carotid stenosis had more severe BAC (p=0,018 and p=0,003, respectively). There was no association between BAC and IMT (p=0,115).Conclusion. BAC is associated with a higher incidence and severity of carotid atheromatosis. A positive relationship was found between the severity of BAC and carotid stenosis. The data obtained confirm the prospects of mammography as a screening technique for identifying individuals with an increased cardiovascular risk.

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Section: Introductionunclassified

Association of breast arterial calcification and carotid atherosclerosis as a marker of cardiovascular risk

Bochkareva,

Butina,

Bayramkulova

et al. 2023

Racionalʹnaâ farmakoterapiâ v kardiologii

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Use of artificial intelligence in the diagnosis of arterial calcification

Trusov,

Chupakhina,

Nurkaeva

et al. 2024

Digital Diagnostics

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Justification. The incidence of diseases of the circulatory system of the population of the Russian Federation has been steadily increasing over the past two decades, increasing 2,047 times from 2000 to 2019. The process of vascular calcification implies the deposition of calcium salts in the artery wall, leading to remodeling of the vascular wall. Radiation research methods are the gold standard for the diagnosis of vascular calcification. However, due to the need for medical professionals to process a large amount of data for a certain period of time, the number of diagnostic errors inevitably increases, as well as the efficiency of work decreases. The active development and introduction of artificial intelligence (AI) into clinical practice has opened up opportunities for specialists to solve these problems. The purpose of the study. To analyze the domestic and foreign literature devoted to the use of AI in the diagnosis of various types of vascular calcification, as well as to summarize the prognostic value of vascular calcification and evaluate aspects that prevent the diagnosis of vascular calcification without the use of AI. Material and methods. The authors searched for publications in the electronic databases PubMed, Web of Science, Google Scholar and eLibrary. The search was carried out using the following keywords: "artificial intelligence", "machine learning", "vascular calcification", "artificial intelligence", "machine learning", "vascular calcification". The search was carried out in the time interval from the moment of the foundation of the corresponding database until July 2023. Conclusion. AI has proven itself well in the diagnosis of vascular calcification. In addition to improving accuracy and efficiency, the ability to detail surpasses the capabilities of the manual diagnostic method. AI has reached a level that allows doctors to help instrumental diagnostics in the automatic detection of vascular calcification. AI capabilities can contribute to the effective development of radiology in the future.

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Breast arteries calcification: a potential surrogate marker for cerebrovascular disease

Cited by 2 publications

References 30 publications

Association of breast arterial calcification and carotid atherosclerosis as a marker of cardiovascular risk

Association of breast arterial calcification and carotid atherosclerosis as a marker of cardiovascular risk

Use of artificial intelligence in the diagnosis of arterial calcification

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