Breast Arterial Calcifications on Mammograms Do Not Predict Coronary Heart Disease at Coronary Angiography

Zgheib, Mohammad; Buchbinder, Shalom; Rafeh, Nidal Abi; Elya, Marwan; Raia, Carolyn; Ahern, Kathleen; Smith, Marianne; Costantino, Thomas; Flory, Michael; Lafferty, James; Castellanos, Mario R.

doi:10.1148/radiol.09090102

Cited by 61 publications

(37 citation statements)

References 21 publications

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“…16 Only 4 of 19 studies did not show an association between BAC and CAD, 10,12,13,16 13 of 19 (68%) studies showed a clear cut, statistically significant association, and 2 of 19 studies showed significant association only when obstructive CAD (≥50% stenosis) was considered. 11,14 Obstructive CAD was generally defined as ≥50% coronary artery stenosis, except by Sarrafzadegann et al, 16 who used ≥50% stenosis in left main coronary artery and/or ≥75% stenosis in other epicardial arteries as the definition of obstructive CAD. There was 1 prospective cohort study, 7 2 retrospective cohort studies, 8,9 9 case-control studies with CAD, 10–18 1 case-control study with BAC, 19 and 7 cross-sectional (prevalence) studies.…”

Section: Resultsmentioning

confidence: 99%

“…Please note that some of the crude ORs and P values shown in Table 1 may not be quoted in full text articles of the respective studies, because we calculated these values by a repeat analysis of data based on the information provided in the methods and results sections of each study (see Statistical Analyses under Methods section for details). In addition, we were able to access the full-study database of Zgheib et al, 11 because this study was conducted at our institution (Staten Island University Hospital).…”

Section: Resultsmentioning

confidence: 99%

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Mammographically Detectable Breast Arterial Calcification and Atherosclerosis

Shah

Chainani

Delafontaine

et al. 2014

Cardiology in Review

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Breast arterial calcification (BAC), observed as an incidental finding on screening mammograms, represents degenerative calcific changes occurring in the mammary arteries, with increasing age. The aim of this review is to discuss relevant literature examining relation between BAC and atherosclerosis. After a thorough literature search, in OVID and PubMed, 199 studies were identified, of which 25 were relevant to our review. Data were abstracted from each study and statistical analysis was done, including calculation of odds ratios and construction of forest plots. A total of 35,542 patients were enrolled across 25 studies looking at an association between BAC and coronary artery disease, cardiovascular disease, stroke, cerebral artery disease, carotid and peripheral artery diseases, and coronary artery calcification. A majority of the studies showed a statistically significant relation between BAC and presence of coronary artery disease cardiovascular disease and associated mortality. Sensitivity of BAC in predicting cardiovascular events was low, but specificity was high. BAC was predictive of incident and prevalent stroke but not mortality of stroke. Similarly, BAC was predictive of cerebral, carotid, and peripheral artery diseases. The role of BAC as a surrogate marker of coronary and systemic atherosclerosis is currently uncertain. Its role may be further elucidated by more large-scale prospective studies and clinical experience.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Mammographically Detectable Breast Arterial Calcification and Atherosclerosis

Shah

Chainani

Delafontaine

et al. 2014

Cardiology in Review

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“…In their study, BAC was inversely related to smoking, a finding that has been previously shown as another indication of BAC lacking an inflammatory effect (9). Similarly, Zgheib (18) and Sarrafzadegann (19) did not find a statistically significant relation between angiographically detected coronary heart disease and BAC.…”

Section: Discussionmentioning

confidence: 92%

Breast arterial calcifications and carotid intima-media thickness and haemodynamics: Is there any association?

Büyükkaya

Büyükkaya²,

Altunkaş³

et al. 2014

Anadolu Kardiyol Derg

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Objective: In this study, we aimed to research the relation between breast arterial calcifications (BACs) detected on mammography and two well-known markers of cardiovascular diseases-carotid artery intima-media thickness (C-IMT) and haemodynamics parameters like carotid peak-systolic velocity (PSV), end-diastolic velocity (EDV) and resistive index (RI). Methods: The study group consisted of 50 consecutive BAC (+) women and the control group consisted of 55 BAC (-) women. In all participants, BAC was diagnosed using mammography and C-IMT was measured using B-mode and Doppler ultrasonography. BAC was defined as two linear calcification depositions in a conical periphery or as calcific rings at the mammographic evaluation. Doppler spectrum samples were obtained from 2 cm proximal to the main carotid artery bifurcation. Results: Postmenopausal female patients ranging in age from 40 to 86 included in this study. When the groups were adjusted for age, a statistically significant difference was found between mean C-IMT of BAC (+) and BAC (-) groups (0.81±0.2 vs. 0.69±0.2 mm; p<0.001). No significant differences were observed between BAC (+) and BAC (-) groups in terms of PSV, EDV, RI. Conclusion: The findings of the present study suggest that BAC, diagnosed by mammography, is independently associated with C-IMT. C-IMT measurement is suggested as a useful tool to detect early atherosclerotic changes. However, haemodynamic variables (PSV, EDV, RI) were not statistically different between the BAC (+) and BAC (-) groups. Prospective larger cohort studies are needed to further elucidate whether BAC is an independent risk factor for cardiovascular disease. (Anadolu Kardiyol Derg 2014; 14: 378-82)

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“…Zgheib et al found no correlation between BAC and coronary artery disease (CAD), even when CAD severity was considered (13). Penugonda et al also demonstrated that BAC was not positively associated with CAD or acute cardiovascular event (12).…”

Section: Discussion:-mentioning

confidence: 99%

“…Several investigations have suggested BAC as a marker of arterial disease that could be associated with increased risk of cardiac events (9,10). On the other hand, other studies have reported no significant association between BAC and cardiovascular diseases (11,12,13).…”

Section: Introduction:-mentioning

confidence: 99%

Is Breast Arterial Calcification a Reliable Indicator of Coronary Artery Disease?

Mohamed¹,

Awad²

2016

IJAR

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Breast Arterial Calcifications on Mammograms Do Not Predict Coronary Heart Disease at Coronary Angiography

Abstract: The authors did not observe a correlation between BAC and coronary angiography-detected CHD, even when CHD severity was considered. On the basis of these results, caution should be exercised when using screening mammography-detected BAC to identify patients with CHD.

Cited by 61 publications

References 21 publications

Mammographically Detectable Breast Arterial Calcification and Atherosclerosis

Mammographically Detectable Breast Arterial Calcification and Atherosclerosis

Breast arterial calcifications and carotid intima-media thickness and haemodynamics: Is there any association?

Is Breast Arterial Calcification a Reliable Indicator of Coronary Artery Disease?

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