Breast Arterial Calcification is Associated with the Progression of Coronary Atherosclerosis in Asymptomatic Women: A Preliminary Retrospective Cohort Study

Yoon, Yeonyee E.; Kim, Kyoung Min; Lee, Won–Jae; Han, Junhee; Chun, Eun Ju; Ahn, Soyeon; Choi, Sang Il; Yun, Bo La; Suh, Jung Won

doi:10.1038/s41598-020-59606-y

Cited by 15 publications

(7 citation statements)

References 24 publications

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“…Smoking, HT, and hyperlipidemia are known and proven risk factors for atherosclerosis (11,31,32,42). Our study determined that these chronic diseases did not significantly affect the BAC score, according to the quantitative statistical multivariate analysis.…”

Section: A B a Bmentioning

confidence: 75%

“…It has been suggested that BAC must be reported as part of routine mammography examinations. Patients, radiologists, and referring physicians can use the information as part of collective decision-making regarding cardiac evaluation to maximize the benefit of preventive cardiology strategies (11,17,(39)(40)(41)(42). Besides, mammography is routinely used as a screening test for breast cancer.…”

Section: A B a Bmentioning

confidence: 99%

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Breast arterial calcifications as an indicator of atherosclerotic cardiovascular disease: comparative analysis of coronary computed tomography scoring systems and carotid intima-media thickness

Kadıoğlu¹,

Bahadir²

2022

Quant Imaging Med Surg

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Background: Breast arterial calcification (BAC) is easily detected and commonly observed on screening mammography. That is more frequent among people with diabetes, and these people are at risk of coronary artery disease. The incidence of BAC increases with advancing age. We aimed to determine whether BAC detected by mammography is associated with the development of coronary atherosclerosis in asymptomatic women. It can help reduce morbidity and mortality secondary to atherosclerotic cardiovascular disease.Methods: We included one hundred and eighty women over the age of 40 who underwent mammography screening in this multi-modality study. Mammography evaluated the presence of calcifications, the number of involved arteries, and the distribution. We questioned the patients about cardiovascular risk factors such as hypertension and diabetes. The coronary artery disease severity was assessed according to both Agatston and calcium scores on coronary computed tomography (CT). Besides, the relationship between these scores and correlation with carotid artery intima-media thickness was investigated. We stated mean and standard deviation (SD) for continuous variables and reported frequency distributions and percentages. SPSS software version 25.0 was used to perform the analysis.Results: Overall, 302 of 3,600 cases were positive for BAC. However, 120 of them could be included in the study by the eligibility criteria of our research. In univariate analysis, age, hyperlipidemia, DM, HT, and smoking history were risk factors that significantly affected BAC development. The impact of age and diabetes were maintained in the logistic regression analysis (P<0.005), while the significant effect of the other variables was vanished (P>0.02). Furthermore, moderate and high BAC scores were correlated with higher coronary atherosclerosis scores.Conclusions: BAC may predict an additional risk factor for coronary artery disease, particularly in patients having higher scores. That may be an accurate indicator for subsequent development of coronary arterial calcifications so that it may be possible to reduce morbidity and mortality associated with coronary atherosclerosis.

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Section: A B a Bmentioning

confidence: 75%

Section: A B a Bmentioning

confidence: 99%

Breast arterial calcifications as an indicator of atherosclerotic cardiovascular disease: comparative analysis of coronary computed tomography scoring systems and carotid intima-media thickness

Kadıoğlu¹,

Bahadir²

2022

Quant Imaging Med Surg

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“…Prevalence of BAC on mammography Распространенность КАМЖ при маммографии Введение Кальциноз артерий молочной железы (КАМЖ), легко выявляемый при скрининговой маммографии, морфологически представляет собой кальциноз медиальной оболочки артерий, и с онкологической точки зрения рассматривается как случайная «доброкачественная» находка. Вместе с тем имеется значительный массив данных о связи КАМЖ с высокой распространенностью сердечно-сосудистых заболеваний (ССЗ) [1][2][3], риском неблагоприятных сердечно-сосудистых (СС) событий [1,3,4], кальцинозом коронарных артерий, наличием коронарных атером и высокой вероятностью их прогрессирования [5]. Высказывается мнение, что у женщин наличие КАМЖ может служить новым гендер-специфическим маркером СС риска [4,5], что открывает перспективы для использования маммографии в качестве инструмента ранней диагностики не только рака молочной железы, но и ССЗ.…”

Section: распространенность и степень тяжести кальциноза артерий моло...unclassified

“…Вместе с тем имеется значительный массив данных о связи КАМЖ с высокой распространенностью сердечно-сосудистых заболеваний (ССЗ) [1][2][3], риском неблагоприятных сердечно-сосудистых (СС) событий [1,3,4], кальцинозом коронарных артерий, наличием коронарных атером и высокой вероятностью их прогрессирования [5]. Высказывается мнение, что у женщин наличие КАМЖ может служить новым гендер-специфическим маркером СС риска [4,5], что открывает перспективы для использования маммографии в качестве инструмента ранней диагностики не только рака молочной железы, но и ССЗ.…”

Section: распространенность и степень тяжести кальциноза артерий моло...unclassified

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Prevalence and Severity of Breast Arterial Calcification on Routine Mammography

Bochkareva¹,

Butina²,

Bayramkulova³

et al. 2022

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To determine the frequency of detection and severity of breast arterial calcification (BAC) among women undergoing mammography on the basis of medical institutions in Moscow.Material and methods. The analysis included 4274 digital mammograms of women aged 40-93 who underwent preventive or diagnostic mammography. Standard full-format digital mammograms were performed in craniocaudal and mediolateral oblique projections. In addition to the standard diagnosis of breast disease, all mammograms were evaluated for the presence of BAC. The severity of BAC was assessed on a 12-point scale: mild 3-4 points, moderate 5-6 points, severe 7-12 points.Results. The average frequency of BAC was 10.1%, in the middle age group 50-59 years – 6.0%. The incidence of BAC increased with age, from 0.4% to 0.6% in women <50 years of age to >50% in women ≥80 years of age. A statistically significant and pronounced correlation was found between the woman's age and the presence of BAC r Pearson =0.769 (p<0.001). There was also a less noticeable but statistically significant correlation between age and severity of BAC r Spearman =0.319 (p<0.001). Regression analysis made it possible to estimate the probability of CAD depending on age. In women <50 years of age, only mild to moderate calcification occurred, while those ≥65 years of age had a significant increase in the incidence of severe CAD.Conclusion. There was an expected increase with age in both prevalence and severity of BAC. Cases of severe BAC in women younger than 65 years of age and any BAC in women younger than 50 years of age are atypical and require clarification of their association with cardiovascular and other diseases.

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Epigenetics: a new warrior against cardiovascular calcification, a forerunner in modern lifestyle diseases

Dutta

Sengupta

Chakraborty

2021

Environ Sci Pollut Res

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Breast Arterial Calcification is Associated with the Progression of Coronary Atherosclerosis in Asymptomatic Women: A Preliminary Retrospective Cohort Study

Cited by 15 publications

References 24 publications

Breast arterial calcifications as an indicator of atherosclerotic cardiovascular disease: comparative analysis of coronary computed tomography scoring systems and carotid intima-media thickness

Breast arterial calcifications as an indicator of atherosclerotic cardiovascular disease: comparative analysis of coronary computed tomography scoring systems and carotid intima-media thickness

Prevalence and Severity of Breast Arterial Calcification on Routine Mammography

Epigenetics: a new warrior against cardiovascular calcification, a forerunner in modern lifestyle diseases

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