Breast Angiosarcoma Metastatic to the Ovary

Souza, Frederico; Katkar, Amol; Abbeele, Annick D. Van den; DiPiro, Pamela J.

doi:10.1155/2009/381015

Cited by 9 publications

(11 citation statements)

References 9 publications

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“…In a rare instance, PBA may metastasize to the ovary. Including one case in this series, there were approximately five cases of PBA that metastasized to the ovary . However, lymph node metastases were relatively rare .…”

Section: Discussionmentioning

confidence: 92%

Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

Wang

Lao

et al. 2016

Breast J

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The aim of this study was to present our experience with primary breast angiosarcoma (PBA) by describing a large series of cases with an emphasis on clinicopathologic and radiologic correlations. Thirty-six cases of PBA diagnosed at our institution between 2006 and 2014 were retrospectively evaluated. All but one case occurred in women with a median age of 35.5 years. The majority of patients presented with a deeply located painless mass, whereas a minority manifested as diffuse enlargement or swelling of the breast. Magnetic resonance imaging showed poorly demarcated lesions with low signal intensity on T1-weighted images, markedly high intensity on T2-weighted images, and prolongation of enhancement upon dynamic study. Histologically, 19 cases (52.8%) were low grade, 12 cases (33.3%) were intermediate grade, and 5 cases (13.9%) were high grade. Follow-up information was available for 27 patients and revealed local recurrence and/or metastasis in 16 patients (59.3%). Five patients (18.5%) died of the disease at a median interval of 20 months. Univariate analysis showed that tumor differentiation had effect on disease-free survival (DFS) (p = 0.005) but failed to predict overall survival (OS) (p = 0.645). The treatment modality was related to OS (p = 0.042) but not DFS (p = 0.131). The Cox proportional hazards regression model suggested that tumor differentiation was an independent predictor of DFS (p = 0.015). We hypothesize that tumor differentiation may be used as a prognostic factor for this rare malignancy. Clinicopathologic and radiologic correlation may help pathologists to arrive at the correct diagnosis of PBA.

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Section: Discussionmentioning

confidence: 92%

Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

Wang

Lao

et al. 2016

Breast J

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“…Of the verifiable reports of ovarian metastasis, all were found at postmortem in the context of widespread disseminated disease [ 12 , 13 ]. To our knowledge, there have been only four confirmed previous cases of breast angiosarcoma metastasizing predominantly to the ovary [ 14 – 17 ]. All the breast tumors were primary, without history of radiotherapy, and occurred in women of childbearing age.…”

Section: Discussionmentioning

confidence: 99%

“…All the breast tumors were primary, without history of radiotherapy, and occurred in women of childbearing age. Of these, one patient presented with synchronous bilateral ovarian tumors as well as splenic metastasis [ 15 ], while two others had had prior breast surgery and presented with a unilateral ovarian mass a few months later [ 14 , 17 ]. In one of the cases, metastasis developed within an ovarian cyst.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Breast with Solitary Metastasis to the Ovary during Pregnancy: An Uncommon Pattern of Metastatic Disease

Wang

Fisher

Thway

2013

Case Reports in Oncological Medicine

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Primary de novo angiosarcoma of the breast is an uncommon, aggressive neoplasm. Here, we present a case of a young woman who initially developed primary angiosarcoma of the breast, and subsequently angiosarcoma of the ovary during pregnancy two years later. Only two confirmed primary angiosarcomas of the breast metastasizing specifically to the ovary have been described in the literature. However, all previous cases had ovarian metastases at presentation or shortly after initial diagnosis. This case is unusual as it occurred after a relatively long interval, and apparently developed during pregnancy. We discuss this rare phenomenon, as well as the possible factors contributing to the recurrence.

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“…The Gadolinium administration provides a better distinction between solid and cystic compartments of a tumor. Primary ovarian tumors are predominantly cystic, while necrotic areas are also commonly present [18] , [19] . Metastatic ovarian tumors may be mainly solid or consist of both cystic and solid components [18] .…”

Section: Discussionmentioning

confidence: 99%

An ovarian mass after breast cancer: Metachronous carcinoma or metastasis? A case report

Makris

Marinelis

Battista³

et al. 2017

International Journal of Surgery Case Reports

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HighlightsIn the presence of an ovarian mass after breast cancer, differentiating between primary and secondary lesions can be a difficult task.This case report presents a 45-year-old patient with an ovarian mass two years after the diagnosis of breast cancer.Imaging, histology and predominantly immunohistochemistry may provide valuable tools in the assessment of ambiguous cases.Differences in the immunohistochemical profile of primary tumor and metastases should be anticipated.

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Breast Angiosarcoma Metastatic to the Ovary

Cited by 9 publications

References 9 publications

Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

Angiosarcoma of the Breast with Solitary Metastasis to the Ovary during Pregnancy: An Uncommon Pattern of Metastatic Disease

An ovarian mass after breast cancer: Metachronous carcinoma or metastasis? A case report

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