Breast and splenic metastases of squamous cell carcinoma from the uterine cervix: a case report

Aitelhaj, Meryem; Khoyaali, Siham; Boukir, A.; Elkabous, Mustapha; Abahssain, Halima; Mrabti, Hind; Khannoussi, Basma El; Errihani, Hassan

doi:10.1186/1752-1947-8-359

Cited by 12 publications

(13 citation statements)

References 9 publications

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“…Solitary splenic metastasis from squamous cell carcinoma of uterine cervix was first reported by Brufman et al in 1977 [15]. As per our knowledge, 11 cases of squamous cell carcinoma metastatic to spleen without evidence of disseminated disease have been reported [9,[15][16][17][18][19][20][21][22][23][24]. Our case is possibly the 12th reported case.…”

Section: Discussionmentioning

confidence: 59%

Splenic Metastasis from Cancer of Uterine Cervix—a Rare Case

Dixit

Mohammed

Shetty

2016

Indian J Surg Oncol

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Cancer of uterine cervix is one of the most common malignancies in women. Metastatic recurrence of cervical cancer in spleen is rare, mostly seen in autopsies. Splenic metastasis from cervical cancer in a living patient without disseminated metastases is rarer. Here, we present the case of a lady aged 46 years with cervical cancer-squamous cell carcinoma-who had undergone radical hysterectomy and postoperative 50 Gy of intensity modulated radiation therapy in 25 fractions and 50 mg of weekly cisplatin for 6 weeks. She was doing well for 17 months. Then, she developed fever and anorexia, and was detected to have splenic lesion and a lesion in the pelvic mesentery in PET/CT (positron emission tomography-computed tomography). Laparoscopy showed enlarged spleen with a mass lesion and a mass in ileal mesentery adherent to the peritoneum over the fundus of bladder and greater omentum. She underwent resection of a segment of ileum with the mesenteric lesion and omentum and bladder peritoneum laparoscopically and splenectomy. Histopathological examination revealed both the mesenteric and splenic lesions to be metastases from poorly differentiated carcinoma, which was from the cervical cancer. Immunohistochemistry was suggestive of squamous cell carcinoma associated with high-risk human papilloma virus. After the postoperative recovery, patient was started on ciplatin with paclitaxel chemotherapy.

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Section: Discussionmentioning

confidence: 59%

Splenic Metastasis from Cancer of Uterine Cervix—a Rare Case

Dixit

Mohammed

Shetty

2016

Indian J Surg Oncol

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“…Skin or nipple cancer and metastasis sites should be excluded when SCC is diagnosed [12]. The clinical symptoms of implant-associated SCC are likely to be a primary mammary tumour, and the histological appearance is important to make the diagnosis [13,14]. In this report, the woman had no histologic indications of primary breast cancer, as she had a mastectomy 10 years ago.…”

Section: Discussionmentioning

confidence: 80%

Breast prosthetic implant-associated Squamous Cell Carcinoma: A case report and Literature Review

Liu

Zhao

et al. 2021

Preprint

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BackgroundBreast reconstruction is widely used for women undergoing mastectomy. Prosthetic implants have become a common technique performed for these women because of their safety, flexibility and adjustable size. There are few reports of implant-associated squamous cell carcinoma. In addition to this report, only 8 reports including 11 cases have been reported in the English literature.Case presentationWe report the case of a patient with breast prosthetic implant-associated squamous cell carcinoma who received mastectomy and prosthetic implants 10 years ago. She was recently hospitalized with unilateral breast enlargement. Surgical pathology showed squamous cell carcinoma around the breast implant. There was no evidence of primary squamous cell carcinoma at any other anatomic site. We analysed all 11 patients with breast implant-derived squamous cell carcinoma (SCC) from a thorough literature search to identify studies. The median age of patients at SCC diagnosis was 56.8 years old. The average time from initial breast augmentation until SCC diagnosis was 21.9 years. The prognosis was poor; 4 of the 11 patients eventually progressed or died within 1 year, 3 of the 11 patients were disease free during the follow-up period, and 4 of the 11 patients were lost to follow-up. The most widespread opinion is that chronic inflammation from breast implants plays a substantial role in the disease progression of SCC.ConclusionsWe reported the rare complications associated with breast prosthetic implants and reviewed the literature. This malignancy should be taken into account in patients with breast prosthetic implants who have acute breast pain and enlargement.

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“…As reported in the literature, the incidence of splenic metastases from cervical cancer ranged from 1/92 to 8/108 in autopsy cases 4 . To the best of our knowledge, only 17 cases of splenic metastasis resulting from cervical cancer have been reported in the literature (Supplementary Table ), including ours 5‐15 . The stages of the 17‐splenic metastasis retrieved from the literature were as follows: 11.76% (2/17) in stage IB, 23.53% (4/17) in stage IIA, 47.06% (8/17) in stage IIB, 5.88% (1/17) in stage IIIB, and 5.88%(1/17) in stage IVA.…”

Section: Discussionmentioning

confidence: 98%