Breast and prostate cancer: more similar than different

Risbridger, Gail P.; Davis, Ian D.; Birrell, Stephen N.; Tilley, Wayne D.

doi:10.1038/nrc2795

Cited by 216 publications

(170 citation statements)

References 114 publications

Supporting

Mentioning

159

Contrasting

Unclassified

Order By: Relevance

“…Strong environmental risk factors linking PCa with endocrine and nervous system tumors, myeloma, or melanoma are not apparent, and thus a genetic contribution is likely [2]. For the association with breast cancer, BRCA2 mutations may contribute; however, because the PCa association was stronger in families with a single breast cancer in comparison to those with multiple breast cancers, shared hormonal pathways may be the main common mechanism [6,7]. The RR of PCa in Swedish BRCA2 mutation carriers was reported to be only 2.3 [8].…”

Section: [ ( F I G _ 1 ) T D $ F I G ]mentioning

confidence: 99%

Familial Associations Between Prostate Cancer and Other Cancers

et al. 2017

View full text Add to dashboard Cite

Prostate cancer (PCa) has the largest familial component of all common cancers: 22% of diagnosed men have a firstdegree relative-a father, a brother, or both-diagnosed with the same cancer, and high-risk families with at least three affected first-degree relatives account for 15% of familial PCa and 3% of all PCa [1]. Nevertheless, the search for highrisk predisposing genes has not been successful. Although BRCA2 and HOXB13 mutations confer an increased individual risk of PCa, their population impact is modest [2]. In addition, numerous low-penetrance loci have been described for PCa, and the known loci and the above mutations

show abstract

Section: [ ( F I G _ 1 ) T D $ F I G ]mentioning

confidence: 99%

Familial Associations Between Prostate Cancer and Other Cancers

et al. 2017

View full text Add to dashboard Cite

show abstract

“…83 This apparent switch in TGFβ function has been reflected in a model of breast cancer progression, where it is evident TGFβ can switch from a tumor suppressor to a pro-metastatic factor. 124 At present, data showing the molecular mechanisms controlling PII aromatase gene transcription in the testis are limited, although a valuable exercise is to use information from other tissues and organs to provide potential clues from well characterized aromatase regulated tissues such as the breast and prostate, 125 and indeed many factors that have been implicated in progression of disease in these tissues are known to be present in the testis. Nonetheless, majority of data suggests that is the conjoint action of SF-1/LRH-1 and phosphorylated CREB binding to their corresponding response elements on PII that contribute to constitutive active aromatase expression.…”

Section: Molecular Mechanisms Controlling Aromatase Gene Expression Imentioning

confidence: 99%

Teasing out the role of aromatase in the healthy and diseased testis

Haverfield

Ham

Brown³

et al. 2011

Spermatogenesis

View full text Add to dashboard Cite

“…The identification of genetic alterations in cancer cells is crucial for the development of more effective methods for early diagnosis, as well as to provide targets for treatment and therapeutic interventions. The analysis of the similarities and differences between breast and prostate cancers provides doi: 10.18282/amor.v2.i2.70 a fascinating picture of the natural history, biological basis and clinical features of these two endocrine-related cancers and suggest that breast and prostate cancer may represent, in some aspects, homologous cancers in females and males [3,4] . Indeed, several studies have shown that a few genes which have been widely accepted to be breast cancer-specific (e.g.…”

Section: Introductionmentioning

confidence: 99%

Oligoadenylate synthetase 1 (OAS1) expression in human breast and prostate cancer cases, and its regulation by sex steroid hormones

Maia¹,

Rocha²,

Socorro³

et al. 2016

Adv Mod Oncol Res

View full text Add to dashboard Cite

Oligoadenylate synthetase 1 (OAS1) is an interferon-induced protein characterised by its capacity to catalyse the synthesis of 2ʹ-5ʹ-linked oligomers of adenosine from adenosine triphosphate (2-5A). The 2-5A binds to a latent Ribonuclease L (RNase L), which subsequently dimerises into its active form and may play an important role in the control of cell growth, differentiation and apoptosis. Previously, our research group identified OAS1 as a differentially-expressed gene in breast and prostate cancer cell lines when compared to normal cells. This study evaluates: i) the expression of OAS1 in human breast and prostate cancer specimens; and ii) the effect of sex steroid hormones in regulating the expression of OAS1 in breast (MCF-7) and prostate (LNCaP) cancer cell lines. The obtained results showed that OAS1 expression was down-regulated in human infiltrative ductal carcinoma of breast, adenocarcinoma of prostate, and benign prostate hyperplasia, both at mRNA and protein level. In addition, OAS1 expression was negatively correlated with the progression of breast and prostate cancer. With regards to the regulation of OAS1 gene, it was demonstrated that 17β-estradiol (E 2 ) down-regulates OAS1 gene in MCF-7 cell lines, an effect that seems to be dependent on the activation of oestrogen receptor (ER). On the other hand, 5α-dihydrotestosterone (DHT) treatment showed no effect on the expression of OAS1 in LNCaP cell lines. The lower levels of OAS1 in breast and prostate cancer cases indicated that the OAS1/RNaseL apoptotic pathway may be compromised in breast and prostate tumours. Moreover, the present findings suggested that this effect may be enhanced by oestrogen in ER-positive breast cancers.Keywords: OAS1; oestrogen; androgen; breast cancer; prostate cancer Citation: Maia CJ, Rocha SM, Socorro S, Schmitt F, Santos CR. Oligoadenylate synthetase 1 (OAS1) expression in human breast and prostate cancer cases, and its regulation by sex steroid hormones. Adv Mod Oncol Res 2016; 2(2): 97-104; http://dx

show abstract

Breast and prostate cancer: more similar than different

Cited by 216 publications

References 114 publications

Familial Associations Between Prostate Cancer and Other Cancers

Familial Associations Between Prostate Cancer and Other Cancers

Teasing out the role of aromatase in the healthy and diseased testis

Oligoadenylate synthetase 1 (OAS1) expression in human breast and prostate cancer cases, and its regulation by sex steroid hormones

Contact Info

Product

Resources

About