Breast Adipose Tissue Estrogen Metabolism in Postmenopausal Women With or Without Breast Cancer

Savolainen-Peltonen, Hanna; Vihma, Veera; Leidenius, Marjut; Wang, Feng; Turpeinen, Ursula; Hämäläinen, Esa; Tikkanen, Matti J.; Mikkola, Tomi S.

doi:10.1210/jc.2014-2550

Cited by 35 publications

(37 citation statements)

References 37 publications

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“…The majority of human studies have been conducted in breast cancer patients (n=7) (66,68,70,75–78). Other studies have been implemented in cancers of the gastrointestinal tract (colorectal cancer (n=4) (8,64,71,73), esophageal cancer (n=2) (65,79), combined (colorectal and esophageal) (n=1) (80)), reproductive cancer (endometrial (n=1) (72), prostate (n=4) (69,74,81,82)), or ENT tract (tongue (n=1) (83)).…”

Section: Resultsmentioning

confidence: 99%

“…Of interest, while the risk for breast cancer is increased for obese postmenopausal women, premenopausal obese women have a lower incidence of breast cancer (84). Adipocytes comprise about 90% of the normal breast tissue and thus, the question of adipocytes contributing directly to tumor progression as part of the tumor stroma has been addressed in several studies (66,68,70,75,76). Breast cancer stroma can be classified into adipose stroma cancer (>50% of cells are adipocytes), and fibrous stroma cancer (100% of cells are fibroblasts) or a combination of both stroma types (<100% of cells are fibroblasts, <50% are adipocytes) (76).…”

Section: Resultsmentioning

confidence: 99%

“…In a small study, Savolainen-Peltonen et al examined the concentrations of estrone, estradiol, and estradiol fatty acyl ester and the mRNA expression of estrogen-converting enzymes in subcutaneous breast adipose tissue (70). Samples were collected from postmenopausal women either with ER-positive breast cancer (n=14) or undergoing breast reduction mammoplasty (controls) (n=14) (70).…”

Section: Resultsmentioning

confidence: 99%

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Signals from the Adipose Microenvironment and the Obesity–Cancer Link—A Systematic Review

Himbert

Delphan

Scherer

et al. 2017

Cancer Prevention Research

154

131

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Obesity and its associated metabolic dysregulation are established risk factors for many cancers. However, the biologic mechanisms underlying this relationship remain incompletely understood. Given the rising rates of both obesity and cancer worldwide, and the challenges for many people to lose excess adipose tissue, a systematic approach to identify potential molecular and metabolic targets is needed to develop effective mechanism-based strategies for the prevention and control of obesity-driven cancer. Epidemiological, clinical, and preclinical data suggest that within the growth-promoting, pro-inflammatory microenvironment accompanying obesity, crosstalk between adipose tissue (comprised of adipocytes, macrophages and other cells) and cancer-prone cells may occur via obesity-associated hormones, cytokines, and other mediators that have been linked to increased cancer risk and/or progression. We report here a systematic review on the direct “crosstalk” between adipose tissue and carcinomas in humans. We identified 4,641 articles with n=20 human clinical studies which are summarized as: (a) breast (n=7), (b) colorectal (n=4), (c) esophageal (n=2), (d) esophageal/colorectal (n=1), (e) endometrial (n=1), (f) prostate (n=4), and (g) ear-nose-throat (ENT) cancer (n=1). Findings from these clinical studies reinforce preclinical data and suggest organ-dependent crosstalk between adipose tissue and carcinomas via VEGF, IL-6, TNF-alpha and other mechanisms. Moreover, visceral white adipose tissue (VAT) plays a more central role as it is more bio-energetically active and is associated with a more pro-cancer secretome than subcutaneous adipose tissue (SAT). Efforts to eavesdrop and ultimately interfere with this cancer-enhancing crosstalk may lead to new targets and strategies for decreasing the burden of obesity-related cancers.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Signals from the Adipose Microenvironment and the Obesity–Cancer Link—A Systematic Review

Himbert

Delphan

Scherer

et al. 2017

Cancer Prevention Research

154

131

View full text Add to dashboard Cite

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“…Moreover, both breast cancer cells and adipocytes play an important role in inducing aromatase in carcinoma cells and stromal cells at the breast cancer invasion front [70]. In contrast, a recent study revealed lower estradiol production in adjacent adipose tissue of estrogen receptor positive post-menopausal breast cancer patients compared to the adipose tissue of patients with breast reduction mammoplasty, while serum concentrations did not differ [71]. Although these studies were preliminary, not always age-and/or body mass index (BMI)-matched, and performed on only small groups of patients, making it hard to draw definite conclusions, they indicate that breast cancer cells can influence local adipose tissue hormone production and vice versa.…”

Section: Adipose Tissue and Hormone Metabolismmentioning

confidence: 95%

When fat becomes an ally of the enemy: adipose tissue as collaborator in human breast cancer

Lapeire

Denys

Cocquyt

et al. 2015

Hormone Molecular Biology and Clinical Investigation

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Since the discovery of leptin in 1994, our vision of adipose tissue as a static organ regulating mainly lipid storage and release has been completely overthrown, and adipose tissue is now seen as an active and integral organ in human physiology. In the past years, extensive research has tremendously given us more insights in the mechanisms and pathways involved not only in normal but also in 'sick' adipose tissue, for example, in obesity and lipodystrophy. With growing evidence of a link between obesity and several types of cancer, research focusing on the interaction between adipose tissue and cancer has begun to unravel the interesting but complex multi-lateral communication between the different players. With breast cancer as one of the first cancer types where a positive correlation between obesity and breast cancer incidence and prognosis in post-menopausal women was found, we have focused this review on the paracrine and endocrine role of adipose tissue in breast cancer initiation and progression. As important inter-species differences in adipose tissue occur, we mainly selected human adipose tissue- and breast cancer-based studies with a short reflection on therapeutic possibilities. This review is part of the special issue on "Adiposopathy in Cancer and (Cardio)Metabolic Diseases".

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“…Végül a 4-hidroxi-ösztrogének az öszt-rogénreceptorokhoz kapcsolódva aktiválják az ER mediálta jelátviteli útvonalakat, ezzel iniciálva a DNS-károsító mechanizmusokat. Mivel az egyes folyamatok a szöveti mikrotérben, igen kis mennyiségű vegyület részvételével játszódnak le, a szisztémás ösztradiolszintek mérése az ösztrogénhatással összefüggő kórfolyamatok korai diagnózisában és monitorozásában nem elégséges [34].…”

Section: Az öSztrogénmetabolitok Biológiai Hatásaiunclassified

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

Kovács

Vásárhelyi

Mészáros³

et al. 2017

Orvosi Hetilap

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Az ösztrogénhormonok fiziológiai szerepe sok tekintetben ismert. Meglehetősen kevés információ áll azonban rendelkezésre az ösztron és az ösztradiol lebontása során képződő vegyületek szerepéről a különböző, ösztrogénhatással összefüggésbe hozott kórképekben. A kutatások intenzív érdeklődésének középpontjában jelenleg a két ösztrogén-hormon mellett tizenhárom extragonadális metabolit áll. A képződő metabolitok protektív vagy éppen proinflammatorikus és/vagy proonkogén hatással rendelkeznek. A szisztémás keringésben mért metabolitszintek nem mutatnak összefüggést a lokálisan megjelenő metabolitokéval, ennek a jövőben diagnosztikai jelentősége lehet. A jelen tanulmány célja a perifériás szövetekben az extragonadális metabolommal kapcsolatos irodalmi források átfogó áttekintése, valamint felhívni a figyelmet a perifériás szövetek ösztrogénhomeosztázisának szerepére, az ösztrogénmetabolom igazolt, valamint a klasszikus hormonhatásoktól eltérő biológiai aktivitására, egyes kórfolyamatokban azonosított klinikai jelentőségére. Ezek az ismeretek a lokálisan determinált kórfolyamatok megértését, korai diagnosztikáját a későbbiekben a metabolomika eszköztárával jelentősen segíthetik. Orv Hetil. 2017; 158(24): 929-937. Kulcsszavak: ösztrogénmetabolom, perifériás szövetek, emlőkarcinóma, HPLC-MS/MS The biological and clinical relevance of estrogen metabolomeConsiderable knowledge has been gathered on the physiological role of estrogens. However, fairly little information is available on the role of compounds produced in the breakdown process of estrone and estradiol wich may play a role in various diseases associated with estrogen impact. To date, approximately 15 extragonadal estrogen-related compounds have been identified. These metabolites may exert protective, or, instead, pro-inflammatory and/or prooncogenic activity in a tissue-specific manner. Systemic and local estrogen metabolite levels are not necesserily correlated, which may promote the diagnostic significance of the locally produced estrogen metabolites in the future. The aim of the present study is a bibliographic review of the extragonadal metabolome in peripheral tissues, and to highlight the role of the peripheral tissue homeostasis of estrogens as well as the non-hormonal biological activity and clinical significance of the estrogen metabolome.

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Breast Adipose Tissue Estrogen Metabolism in Postmenopausal Women With or Without Breast Cancer

Cited by 35 publications

References 37 publications

Signals from the Adipose Microenvironment and the Obesity–Cancer Link—A Systematic Review

Signals from the Adipose Microenvironment and the Obesity–Cancer Link—A Systematic Review

When fat becomes an ally of the enemy: adipose tissue as collaborator in human breast cancer

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

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