Breast adenomyoepithelioma, a case report

El-Helou, Etienne; Terro, Jad J.; Kansoun, Alaa; Neaime, Georges Robert; Haytham, Mochairefa; Ismail, Nathalie Haidar; Naccour, Jessica; Zaarour, Mariana; Alam, Houssam

doi:10.1016/j.ijscr.2020.11.110

Cited by 6 publications

(7 citation statements)

References 15 publications

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“…Histologically, AME exhibits significant heterogeneity, which can pose challenges in accurate diagnosis [2].…”

Section: Discussionmentioning

confidence: 99%

Adenomyoepithelioma: A Case Report of a Rare Breast Lump

Jayakar,

Tiwari,

Sri Sai Teja Sampath

et al. 2024

Cureus

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Adenomyoepithelioma (AME) of the breast is a rare tumor characterized by biphasic differentiation into luminal and myoepithelial cells, with various histological patterns observed. This case report details a 35-year-old female with a progressively enlarging breast lump diagnosed initially as a fibroadenoma through ultrasonography (USG) and fine-needle aspiration cytology (FNAC). The patient underwent successful excision of the lump under general anesthesia, with histopathological examination confirming a benign tumor comprising epithelial and myoepithelial cells. This case underscores the importance of comprehensive clinical assessment and accurate diagnostic techniques in managing breast lumps, emphasizing the need for timely intervention for favorable outcomes.

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“…Histologically, AME exhibits significant heterogeneity, which can pose challenges in accurate diagnosis [2].…”

Section: Discussionmentioning

confidence: 99%

Adenomyoepithelioma: A Case Report of a Rare Breast Lump

Jayakar,

Tiwari,

Sri Sai Teja Sampath

et al. 2024

Cureus

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“…These tumors can appear at different ages ranging from 16 to 86 years [ 5 ], with a median age of 56.75 years [ 6 ]. Our patient was only 34 years old.…”

Section: Discussionmentioning

confidence: 99%

“…If narrow margins or incomplete margins are detected, a second excision is needed [ 17 ]. Recurrences have been described between 4 months or as late as 23 years [ 5 ]. The spreading to other sites is possible and have been seen in the lungs, liver, brain, thyroid, soft tissue and bone; suggesting that there is more likely a hematogenous spreading rather than a lymphatic one [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Benign adenomyoepithelioma of the breast: a case report

Belhaddad¹,

Souabni²,

Nejmaddine³

et al. 2022

Pan Afr Med J

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The diagnosis of adenomyoepitheliomas is difficult and relies on the presence of a double component of epithelial and myoepithelial cells belonging to the breast lobules and ducts. The clinical and imaging characteristics are not specific; thus, the diagnosis is histological. In this article, we present a case of a young female who presented with a 2 cm lump in the breast without other clinical symptoms, which revealed a benign adenomyoepithelioma (AME). We performed a large excisional lumpectomy, and the patient recovered well with no complication or recurrence within two years follow-up. When it comes to adenomyoepitheliomas, the published literature is mainly composed of case reports, so much so that there are no evidence-based guidelines. Our case shows that an excisional lumpectomy is often enough when facing a small size tumor with no signs of malignancy, which contributes to the limited data on the subject.

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“…These lesions were mostly unilateral without signi cant differences between the left and right sides, and site is independent of both DFS and OS (P > 0.05 for both). Patients with a malignant AME of the breast could present with a palpable mass [3,4]. The patient is usually preceded by a longstanding stable mass, followed by a period of rapid growth [5].…”

Section: Discussionmentioning

confidence: 99%

Challenges in the Management of Malignant Adenomioepithelioma of the Breast: a Case Report and Review of the Literatures

Wang¹,

Yan²,

Li³

et al. 2021

Preprint

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Background: Malignant adenomyeloblastoma is a rare tumor, with no guidelines available for its treatment. Case presentation: We discuss a case of malignant adenomyeloblastoma of the right breast in a 59-year-old woman. The patient underwent a lumpectomy, and pathological diagnosis of malignant adenomyeloblastoma was distinct from the preoperative needle-biopsy diagnosis of intraductal papilloma. The patient underwent mastectomy and chemotherapy immediately. However, local recurrence was occurred 11 months after the initial operation. We summarize the characteristics of patients with malignant adenomyeloblastoma in PubMed and Web of Science databases, and share our experience and discoveries. Statistics included the univariate and multivariable Cox proportional hazards models. Overall, 34 patients were analyzed. Conclusions: At diagnosis, the median age was 59.3 years and the median tumor size was 30.0 mm. The most common initial surgery was breast-conserving surgery (50%), and a proportion of patients underwent axillary lymph node dissection (32%). Age, max diameter, and axillary status were associated with overall survival. Complete surgical excision with adequate margins is the most important treatment. Patients may not benefit from remedial adjuvant therapy, but may benefit from prompt postoperative adjuvant therapy. Multidisciplinary cooperation and follow-up are essential for the management of these patients. Our data would provide novel insights into a rare tumor that might avoid over- or under-treatment of the patients.

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Breast adenomyoepithelioma, a case report

Cited by 6 publications

References 15 publications

Adenomyoepithelioma: A Case Report of a Rare Breast Lump

Adenomyoepithelioma: A Case Report of a Rare Breast Lump

Benign adenomyoepithelioma of the breast: a case report

Challenges in the Management of Malignant Adenomioepithelioma of the Breast: a Case Report and Review of the Literatures

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