Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina

Uschner, Diane; Bott, Matthew; Lagarde, William H.; Keating, Joseph; Tapp, Hazel; Berry, Andrea A.; Seals, Austin; Munawar, Iqra; Schieffelin, John S.; Yukich, Joshua; Santacatterina, Michele; Gunaratne, Mihili; Fette, Lida M.; Burke, Brian; Strylewicz, Greg; Edelstein, Sharon L.; Ahmed, Amina; Miller, Kristen; Sanders, John W.; Herrington, David M.; Weintraub, William S.; Runyon, Michael S.

doi:10.3390/vaccines10111922

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…In the multivariate analysis, we found that breakthrough infections were more common in younger age groups, such as 67% (25 years old) and 28% (25-50 years old), compared to 5.5% in older age groups (> 50 years old), which we attribute to young people's social behavior, higher social contacts, and work-related contacts, which is consistent with other cohorts' reported data [29][30][31]. Similarly, reinfections rates were higher than a single episode of breakthrough infection especially during the wave of the Omicron variant peak [32].…”

Section: Discussionsupporting

confidence: 91%

COVID-19 Breakthrough Infection Among Vaccinated Population in the United Arab Emirates

Dash

Barqawi

Obaideen

et al. 2023

J Epidemiol Glob Health

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Background Despite significant efforts to contain the Coronavirus Disease 2019 (COVID-19) pandemic through mass vaccination, numerous nations throughout the world have recorded breakout infections. The incidence and severity of COVID-19 breakthrough infections in the United Arab Emirates (UAE) remain unknown despite extensive COVID-19 vaccine coverage. The goal of this research is to establish the characteristics of COVID-19 breakthrough infections in the UAE’s vaccinated population. Methods Between February and March 2022, we conducted a descriptive cross-sectional study in the UAE with 1533 participants to examine the characteristics of COVID-19 breakthrough infection among the vaccinated population. Results The vaccination coverage was 97.97%, and the COVID-19 breakthrough infection rate was 32.1%, requiring hospitalization in 7.7% of cases. The bulk of the 492 COVID-19 breakthrough infections reported was among young adults (67%), with the majority experiencing mild to moderate symptoms (70.7%) or remaining asymptomatic (21.5%). Conclusions COVID-19 breakthrough infection were reported in younger age, male sex, non-healthcare professions, vaccination with inactivated whole virus vaccine (Sinopharm), and not receiving a booster dose. Information on breakthrough infection in the UAE might influence public health decisions and motivate measures such as providing additional booster doses of the vaccines to the people.

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Section: Discussionsupporting

confidence: 91%

COVID-19 Breakthrough Infection Among Vaccinated Population in the United Arab Emirates

Dash

Barqawi

Obaideen

et al. 2023

J Epidemiol Glob Health

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“…Studies on the process of infection have attributed a similar risk of disease to younger and older people, because the process of infection does not differ significantly between the two groups [ 34 ]. However, retrospective cohort studies such as this one, but also prospective cohort studies, repeatedly show that younger age is associated with a higher risk of infection [ 35 , 36 ]. This has recently been shown specifically for breakthrough infections in adults with primary immunization against SARS-CoV-2 [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Results of the Cologne Corona Surveillance (CoCoS) project– a cross-sectional study: survey data on risk factors of SARS-CoV-2 infection, and moderate-to-severe course in primarily immunized adults

Oberste,

Asenova,

Ernst

et al. 2024

BMC Public Health

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Background Amidst the COVID-19 pandemic, vaccination has been a crucial strategy for mitigating transmission and disease severity. However, vaccine-effectiveness may be influenced by various factors, including booster vaccination, as well as personal factors such as age, sex, BMI, smoking, and comorbidities. To investigate the potential effects of these factors on SARS-CoV-2 infection and disease severity, we analyzed data from the third round of the Cologne Corona Surveillance (CoCoS) project, a large cross-sectional survey. Methods The study was conducted mid-February to mid-March 2022 in Cologne, Germany. A random sample of 10,000 residents aged 18 years and older were invited to participate in an online survey. Information on participants’ demographics (age, sex), SARS-CoV-2 infections, vaccination status, smoking, and preexisting medical conditions were collected. The outcomes of the study were: (1) the occurrence of SARS-CoV-2 infection despite vaccination (breakthrough infection) and (2) the occurrence of moderate-to-severe disease as a result of a breakthrough infection. Cox proportional-hazards regression was used to investigate possible associations between the presence/absence of booster vaccination, personal factors and the occurrence of SARS-CoV-2 infection. Associations with moderate-to-severe infection were analyzed using the Fine and Gray subdistribution hazard model. Results A sample of 2,991 residents responded to the questionnaire. A total of 2,623 primary immunized participants were included in the analysis of breakthrough infection and 2,618 in the analysis of SARS-CoV-2 infection severity after exclusions due to incomplete data. The multivariable results show that booster vaccination (HR = 0.613, 95%CI 0.415–0.823) and older age (HR = 0.974, 95%CI 0.966–0.981) were associated with a reduced hazard of breakthrough infection. Regarding the severity of breakthrough infection, older age was associated with a lower risk of moderate-to-severe breakthrough infection (HR = 0.962, 95%CI0.949–0.977). Female sex (HR = 2.570, 95%CI1.435–4.603), smoking (HR = 1.965, 95%CI1.147–3.367) and the presence of chronic lung disease (HR = 2.826, 95%CI1.465–5.450) were associated with an increased hazard of moderate-to-severe breakthrough infection. Conclusion The results provide a first indication of which factors may be associated with SARS-CoV-2 breakthrough infection and moderate-to-severe course of infection despite vaccination. However, the retrospective nature of the study and risk of bias in the reporting of breakthrough infection severity limit the strength of the results. Trial registration DRKS.de, German Clinical Trials Register (DRKS), Identifier: DRKS00024046, Registered on 25 February 2021.

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COVID-19 Vaccines

Hahn¹,

Wiley²

2022

Infectious Disease Clinics of North America

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Breakthrough SARS-CoV-2 Infections after Vaccination in North Carolina

Cited by 5 publications

References 13 publications

COVID-19 Breakthrough Infection Among Vaccinated Population in the United Arab Emirates

COVID-19 Breakthrough Infection Among Vaccinated Population in the United Arab Emirates

Results of the Cologne Corona Surveillance (CoCoS) project– a cross-sectional study: survey data on risk factors of SARS-CoV-2 infection, and moderate-to-severe course in primarily immunized adults

COVID-19 Vaccines

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