Breakthrough infection after SARS-CoV-2 vaccines in patients with hemoglobinopathies and blood-transfusion management: a single Center experience
Andrea Duminuco,
Anna Bulla,
Rosamaria Rosso
et al.
Abstract:Purpose
Immune system impairment is frequently reported in patients affected by hemoglobinopathies due to various mechanisms, including iron accumulation, antigenic stimulation due to numerous transfusions, chronic hemolysis, and a hyperinflammatory state. The antigenic immune response after a vaccine could be ineffective.
Methods
We evaluated the anti-spike IgG production after 2 doses of vaccine for SARS-CoV-2 in patients affected by hemoglobinopathies, reporting the risk of breakthrough infections, monito… Show more
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