Breakthrough Candida Infection in a Preterm Infant with Congenital Cutaneous<i>Candida albicans</i>Infection

Adler, Amos; Litmanovitz, Ita; Regev, Rivka; Arnon, Shmuel; Bauer, Sophia; Dolfin, Tzipora

doi:10.1055/s-2005-864855

Cited by 7 publications

(8 citation statements)

References 18 publications

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“…In addition to fluconazole, breakthrough candidemia can also occur with amphotericin B and caspofungin. 25,26 It is possible that the MIC to fluconazole is higher in isolates from patients with breakthrough candidemia, who wound require a higher dose of fluconazole. However, most of clinical laboratories are not able to provide MICs of Candida species.…”

Section: Discussionmentioning

confidence: 98%

Prognostic factors of candidemia among nonneutropenic adults with total parenteral nutrition

Tsai

Lay

Wang

et al. 2011

Journal of Microbiology, Immunology and Infection

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Section: Discussionmentioning

confidence: 98%

Prognostic factors of candidemia among nonneutropenic adults with total parenteral nutrition

Tsai

Lay

Wang

et al. 2011

Journal of Microbiology, Immunology and Infection

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“…Systemic candidiasis is the most common and fatal cause of fungal sepsis in newborns 4,5. Moreover, 2-4% of neonates with systemic candidiasis are very low birth weight infants (VLBWI), weighing less than 1500g, and have a high mortality rate 6,7.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of AmBisome® to Amphotericin B for Treatment of Systemic Candidiasis in Very Low Birth Weight Infants

et al. 2007

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PurposeAmphotericin B is considered the treatment of choice for systemic candidiasis, but adverse effects may limit its use. An alternative option for the treatment of candidiasis includes lipid preparations of amphotericin B. This study investigated the safety and efficacy of AmBisome®, a lipid formulation of amphotericin B containing liposomal structures, for the treatment of systemic candidiasis in very low birth weight infants (VLBWI).Materials and MethodsData from 26 VLBWI treated with AmBisome® in the study group (AmBisome group) from October 2003 to July 2006 were compared with data from 20 VLBWI treated with amphotericin B as a historical control (Amphotericin group). This study was a prospective, historical control, multi-center trial.ResultsCandida spp. was isolated in 73% (19/26) of the cases for the AmBisome group and 90% (18/20) of the cases for the Amphotericin group. The fungal eradication rate and the time to eradication was 84% (16/19) and 9 ± 8 days in the AmBisome group, and 89% (16/18) and 10 ± 9 days in the Amphotericin group, respectively (p = 0.680 vs p = 0.712). The major adverse effects were lower in the AmBisome group (renal toxicity, 21% vs 55%, p = 0.029; hepatotoxity, 25% vs 65%, p = 0.014, AmBisome group vs Amphotericin group, respectively). There was no significant difference in mortality attributed to systemic candidiasis (12% in the AmBisome group, 10% in the Amphotericin group, p = 0.868).ConclusionAmBisome® is effective and safe for treating systemic fungal infections in VLBWI.

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“…La localización de estas lesiones suele ser en espalda, extremidades, pliegues, palmas, plantas y, ocasionalmente, en uñas y mucosa oral (4). Dicho cuadro es muy poco común y lleva asociadas complicaciones sisté-micas, sobre todo visceromegalias y respiratorias, e incluso la muerte de no ser tratada en su conjunto con antifúngicos (5). El diagnóstico definitivo se establece por el aislamiento e identificación del hongo, y el pronóstico, con la aplicación del tratamiento correcto y oportuno, es bueno (6,7).…”

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Candidiasis cutánea generalizada en recién nacido a término

et al. 2012

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Introducción. La candidiasis cutánea es una enfermedad que afecta tanto a población infantil como adulta. Las forma de presentación puede ser localizada o sistémica y el agente etiológico múltiple, siendo las especies infecciosas de Candida albicans más prevalentes en niños. Objetivo. Presentar un caso de candidiasis cutánea congénita cuya causa aparente fue la transmisión vertical durante el parto. Material y metodología. Se describe el caso de un recién nacido a término expuesto a una candidiasis vaginal subclínica, que desarrolló una candidiasis cutánea congénita por C. albicans asociada a sepsis y dificultad respiratoria en las primeras 24 horas de vida. Se practicaron hemocultivos, biopsia cutánea de las lesiones pápulo-pústulo-vesiculosas, análisis de sangre y punción lumbar. Resultados. En la bioquímica y el hemograma se encontró una proteína C reactiva de 5,7 mg/dl, leucocitosis con desviación a la izquierda y anemia leve. A las 24 horas, en el control se encontró una proteína C reactiva (7,82 mg/dl) que fue en aumento progresivo durante tres días, por lo que se practicó punción lumbar. El hemocultivo fue positivo para Staphylococcus aureus. La biopsia cutánea dio como resultado histológico la candidiasis cutánea. Conclusiones. El diagnóstico precoz es fundamental para prevenir complicaciones derivadas del cuadro producido por C. albicans en neonatos.Palabras clave: recién nacido, Candida albicans, candidiasis, candidemia, infecciones cutáneas estafilocócicas, neonatología. Generalized cutaneous candidiasis in newborn at termIntroduction. Cutaneous candidiasis is a disease that affects children as well as adults. The presentation may be localized or systemic, and with multiple etiological agents. The most prevalent infecting species in children differs from that of the adult. Objective. A case is presented where a congenital cutaneous candidiasis was transmitted to the child during birth. Materials and methods. A full term newborn was exposed to a subclinical vaginal candidiasis infection, and 24 hr after birth, developed congenital cutaneous candidiasis. The etiological agent was Candida albicans, and was associated with sepsis and respiratory distress. Blood cultures, cutaneous biopsy of vesicular lesions, blood tests and lumbar puncture were performed. Results. Biochemistry and blood count showed a CRP of 5.7 mg/dl, leukocytosis with left shift and mild anemia. After 24 hr, the blood analyses showed an increase in a CRP (7.8 mg/dl) and increased progressively for three days; consequently, a lumbar puncture was performed. Blood culture was positive for Staphylococcus aureus. Cutaneous biopsy confirmed the cutaneous candidiasis. Conclusions. The early diagnosis is essential to prevent complications derived by the Candida albicans in newborns.

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Breakthrough Candida Infection in a Preterm Infant with Congenital CutaneousCandida albicansInfection

Cited by 7 publications

References 18 publications

Prognostic factors of candidemia among nonneutropenic adults with total parenteral nutrition

Prognostic factors of candidemia among nonneutropenic adults with total parenteral nutrition

A Comparison of AmBisome® to Amphotericin B for Treatment of Systemic Candidiasis in Very Low Birth Weight Infants

Candidiasis cutánea generalizada en recién nacido a término

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