Breaking the state of the heart: meshless model for cardiac mechanics

Lluch, Èric; Craene, Mathieu De; Bijnens, Bart; Sermesant, Maxime; Noailly, Jérôme; Cámara, Óscar; Morales, Hernán G.

doi:10.1007/s10237-019-01175-9

Cited by 26 publications

(14 citation statements)

References 35 publications

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“…This limited imposition is likely to affect the flow solution in the boundary layer and limit the study of the small‐scale flow features seen in the cardiac flow. However, previous studies have shown that the large‐scale intraventricular hemodynamics as well as the cardiac tissue and heart valve mechanics obtained using the proposed SPH‐based FSI method are in agreement with in vivo, in vitro, and in silico measurements …”

Section: Discussionsupporting

confidence: 51%

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Transapical mitral valve repair with neochordae implantation: FSI analysis of neochordae number and complexity of leaflet prolapse

Caballero

Mao

McKay

et al. 2019

Numer Methods Biomed Eng

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Transapical mitral valve repair with neochordae implantation is a relatively new minimally invasive technique to treat primary mitral regurgitation. Quantifying the complex biomechanical interaction and interdependence between the left heart structures and the neochordae during this procedure is technically challenging. The aim of this parametric computational study is to investigate the immediate effects of neochordae number and complexity of leaflet prolapse on restoring physiologic left heart dynamics after optimal transapical neochordae repair procedures. Neochordae implantation using three and four sutures was modeled under three clinically relevant prolapse conditions: isolated P2, multi‐scallop P2/P3, and multi‐scallop P2/P1. A fluid‐structure interaction (FSI) modeling framework was used to evaluate the left heart dynamics under baseline, prerepair, and postrepair states. Despite immediate restoration of leaflet coaptation and no residual mitral regurgitation in all postrepair models, the average and peak stresses in the repaired scallop(s) increased >40% and >100%, respectively, compared with the baseline state. Additionally, anterior mitral leaflet marginal chordae tension increased >30%, while posterior mitral leaflet chordae tension decreased at least 30%. No marked differences in hemodynamic performance, in native and neochordae forces, and in leaflet stress were found when implanting three or four sutures. We report, to our knowledge, the first set of time‐dependent in silico FSI human neochordae tension measurements during transapical neochordae repair. This work represents a further step towards an improved understanding of the biomechanical outcomes of minimally invasive mitral valve repair procedures.

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Section: Discussionsupporting

confidence: 51%

“…However, previous studies have shown that the large-scale intraventricular hemodynamics as well as the cardiac tissue and heart valve mechanics obtained using the proposed SPH-based FSI method are in agreement with in vivo, in vitro, and in silico measurements. 20,21,[61][62][63]…”

Section: Limitationsmentioning

confidence: 99%

Transapical mitral valve repair with neochordae implantation: FSI analysis of neochordae number and complexity of leaflet prolapse

Caballero

Mao

McKay

et al. 2019

Numer Methods Biomed Eng

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“…Particle methods for heart valves have become more popular over the last decade [78,[115][116][117][118][119][120]. In addition to computational purposes, particle methods could also be used to process the FSI results as a mean of Lagrangian particle tracking for platelet activation [121], flow topology analysis [45], and particle residence time modeling [122].…”

Section: Particle Methodsmentioning

confidence: 99%

Computational Methods for Fluid-Structure Interaction Simulation of Heart Valves in Patient-Specific Left Heart Anatomies

Usta

Aidun

et al. 2022

Fluids

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Given the complexity of human left heart anatomy and valvular structures, the fluid–structure interaction (FSI) simulation of native and prosthetic valves poses a significant challenge for numerical methods. In this review, recent numerical advancements for both fluid and structural solvers for heart valves in patient-specific left hearts are systematically considered, emphasizing the numerical treatments of blood flow and valve surfaces, which are the most critical aspects for accurate simulations. Numerical methods for hemodynamics are considered under both the continuum and discrete (particle) approaches. The numerical treatments for the structural dynamics of aortic/mitral valves and FSI coupling methods between the solid Ωs and fluid domain Ωf are also reviewed. Future work toward more advanced patient-specific simulations is also discussed, including the fusion of high-fidelity simulation within vivo measurements and physics-based digital twining based on data analytics and machine learning techniques.

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“…Tissue mechanics modeling of the fetal CVS has been achieved mainly in the form of finite element modeling (FEM) of myocardial biomechanics. The FEM method divides the solid structure of interest into many small elements, and iteratively solves the governing equations of momentum and deformational mechanics within these elements, to derive a prediction of the deformational and stress characteristics of the object of interest (Lluch et al, 2019). The technique has originally been developed by civil and aeronautical engineers to study structural stability and aircraft structural integrity respectively, and was later imported into biomedical engineering to study myocardial and vascular biomechanics (Costopoulos et al, 2017;Shavik et al, 2018).…”

Section: Sheepmentioning

confidence: 99%

Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease

Rufaihah

Chen

Yap

et al. 2021

Disease Models &Amp; Mechanisms

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Birth defects contribute to ∼0.3% of global infant mortality in the first month of life, and congenital heart disease (CHD) is the most common birth defect among newborns worldwide. Despite the significant impact on human health, most treatments available for this heterogenous group of disorders are palliative at best. For this reason, the complex process of cardiogenesis, governed by multiple interlinked and dose-dependent pathways, is well investigated. Tissue, animal and, more recently, computerized models of the developing heart have facilitated important discoveries that are helping us to understand the genetic, epigenetic and mechanobiological contributors to CHD aetiology. In this Review, we discuss the strengths and limitations of different models of normal and abnormal cardiogenesis, ranging from single-cell systems and 3D cardiac organoids, to small and large animals and organ-level computational models. These investigative tools have revealed a diversity of pathogenic mechanisms that contribute to CHD, including genetic pathways, epigenetic regulators and shear wall stresses, paving the way for new strategies for screening and non-surgical treatment of CHD. As we discuss in this Review, one of the most-valuable advances in recent years has been the creation of highly personalized platforms with which to study individual diseases in clinically relevant settings.

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Breaking the state of the heart: meshless model for cardiac mechanics

Cited by 26 publications

References 35 publications

Transapical mitral valve repair with neochordae implantation: FSI analysis of neochordae number and complexity of leaflet prolapse

Transapical mitral valve repair with neochordae implantation: FSI analysis of neochordae number and complexity of leaflet prolapse

Computational Methods for Fluid-Structure Interaction Simulation of Heart Valves in Patient-Specific Left Heart Anatomies

Mending a broken heart: In vitro, in vivo and in silico models of congenital heart disease

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