Breaking the niche: multidimensional nanotherapeutics for tumor microenvironment modulation

Swetha, K. Laxmi; Maravajjala, Kavya Sree; Li, Shyh-Dar; Singh, Manu Smriti; Roy, Aniruddha

doi:10.1007/s13346-022-01194-7

Cited by 3 publications

(2 citation statements)

References 245 publications

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“…If the physicochemical properties of the two drugs are significantly different, then liposomes with the hydrophobic lipid bilayer and hydrophilic core, polymer NPs prepared by the double emulsion method, or carrier-free self-assembled nanoparticles can be selected. 173,174 Phagocytosis of the endothelial system, protein crown construction, blood clearance, and rapid enzyme degradation hinder the delivery of free chemotherapeutic and immunotherapeutic agents to the tumor site. Due to the loss of rapid blood elimination and non-targeted distribution, large doses are often required, which can accumulate stronger toxicity in the body.…”

Section: Advantages Of Nddssmentioning

confidence: 99%

“…Therefore, in the design stage, more consideration should be given to practical application and cost-effective preparation of NDDSs with robust production capacity to increase the opportunity of commercialization. 174 Another challenge is the need to optimize the combination of chemoimmunotherapies. Combination regimens typically involve multiple drugs, so they are complex and need to be properly designed.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

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Nanoparticle-Mediated Synergistic Chemoimmunotherapy for Cancer Treatment

Lang,

Wang,

Han

et al. 2024

IJN

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Until now, there has been a lack of effective strategies for cancer treatment. Immunotherapy has high potential in treating several cancers but its efficacy is limited as a monotherapy. Chemoimmunotherapy (CIT) holds promise to be widely used in cancer treatment. Therefore, identifying their involvement and potential synergy in CIT approaches is decisive. Nano-based drug delivery systems (NDDSs) are ideal delivery systems because they can simultaneously target immune cells and cancer cells, promoting drug accumulation, and reducing the toxicity of the drug. In this review, we first introduce five current immunotherapies, including immune checkpoint blocking (ICB), adoptive cell transfer therapy (ACT), cancer vaccines, oncolytic virus therapy (OVT) and cytokine therapy. Subsequently, the immunomodulatory effects of chemotherapy by inducing immunogenic cell death (ICD), promoting tumor killer cell infiltration, down-regulating immunosuppressive cells, and inhibiting immune checkpoints have been described. Finally, the NDDSsmediated collaborative drug delivery systems have been introduced in detail, and the development of NDDSs-mediated CIT nanoparticles has been prospected.

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Section: Advantages Of Nddssmentioning

confidence: 99%

Section: Conclusion and Perspectivementioning

confidence: 99%

Nanoparticle-Mediated Synergistic Chemoimmunotherapy for Cancer Treatment

Lang,

Wang,

Han

et al. 2024

IJN

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Overcoming drug resistance with a docetaxel and disulfiram loaded pH-sensitive nanoparticle

Swetha

Paul

Maravajjala

et al. 2023

Journal of Controlled Release

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Breast Cancer Treatment Strategies Targeting the Tumor Microenvironment: How to Convert “Cold” Tumors to “Hot” Tumors

Yang,

Hu,

Huang

2024

IJMS

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Breast cancer characterized as “cold tumors” exhibit low levels of immune cell infiltration, which limits the efficacy of conventional immunotherapy. Recent studies have focused on strategies using nanotechnology combined with tumor microenvironment modulation to transform “cold tumors” into “hot tumors”. This approach involves the use of functionalized nanoparticles that target and modify the tumor microenvironment to promote the infiltration and activation of antitumor immune cells. By delivering immune activators or blocking immunosuppressive signals, these nanoparticles activate otherwise dormant immune responses, enhancing tumor immunogenicity and the therapeutic response. These strategies not only promise to increase the response rate of breast cancer patients to existing immunotherapies but also may pave new therapeutic avenues, providing a new direction for the immunotherapy of breast cancer.

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Breaking the niche: multidimensional nanotherapeutics for tumor microenvironment modulation

Cited by 3 publications

References 245 publications

Nanoparticle-Mediated Synergistic Chemoimmunotherapy for Cancer Treatment

Nanoparticle-Mediated Synergistic Chemoimmunotherapy for Cancer Treatment

Overcoming drug resistance with a docetaxel and disulfiram loaded pH-sensitive nanoparticle

Breast Cancer Treatment Strategies Targeting the Tumor Microenvironment: How to Convert “Cold” Tumors to “Hot” Tumors

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