Breaking down the human motor cortex: the layer‐specific measurement of corticospinal neuronal activity

Dukkipati, Saihari S.; Trevarrow, Michael P.

doi:10.1113/jp278504

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…For example, Kurz et al (2019) developed a novel non-invasive method that combines single-pulses TMS with peripheral nerve stimulations of the median nerve generating an H-reflex. This technique makes it possible to estimate excitability changes of different micro-circuits of M1 which reflect layer-specific activity (Dukkipati & Trevarrow, 2019; Kurz et al ., 2019). Since layer-specific cortical circuits activity has been recently evidenced during MI (Persichetti et al ., 2020) and that corticospinal neurons responsible for the early and late I-waves pathways are thought to originate from layer-specific cortical circuits, the technique of Kurz et al could be a promising tool to delineate further the different subsets of neurons in M1 activated during MI.…”

Section: Discussionmentioning

confidence: 99%

The recruitment of indirect-waves within primary motor cortex during motor imagery: A directional Transcranial Magnetic Stimulation study

Neige

Ciechelski

Lebon

2022

Preprint

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Motor imagery (MI) refers to the mental simulation of an action without any overt movement. While numerous transcranial magnetic stimulation (TMS) studies provided evidence for a modulation of corticospinal excitability and intracortical inhibition during MI, the neural signature within the primary motor cortex is not clearly established. In the current study, we used directional TMS to probe the modulation of the excitability of early and late indirect-waves (I-waves) generating pathways during MI. Corticospinal responses evoked by TMS with posterior-anterior (PA) and anterior-posterior (AP) current flow within primary motor cortex evoke preferentially early and late I-waves, respectively. Seventeen participants were instructed to stay at rest or to imagine isometric maximal contractions of the right flexor carpi radialis. We demonstrated that the increase of corticospinal excitability during MI is greater with PA than AP orientation. By using paired-pulse stimulations, we confirmed that short-interval intracortical inhibition (SICI) increased during MI in comparison to rest with PA orientation whereas we found that it decreased with AP orientation. Overall, these results indicate that the specific early I-waves generating pathway activated by PA orientation is probably more sensitive to the corticospinal excitability and intracortical inhibition modulations induced by MI.

show abstract

Section: Discussionmentioning

confidence: 99%

The recruitment of indirect-waves within primary motor cortex during motor imagery: A directional Transcranial Magnetic Stimulation study

Neige

Ciechelski

Lebon

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, Kurz et al (2019) developed a novel non‐invasive method that combines single‐pulse TMS with peripheral nerve stimulations of the median nerve generating an H‐reflex. This technique makes it possible to estimate excitability changes of different microcircuits of M1, which reflect layer‐specific activity (Dukkipati & Trevarrow, 2019; Kurz et al, 2019). Because layer‐specific cortical circuit activity has been recently evidenced during MI (Persichetti et al, 2020) and corticospinal neurons responsible for the early and late I‐waves pathways are thought to originate from layer‐specific cortical circuits, the technique of Kurz et al could be a promising tool to delineate further the different subsets of neurons in M1 activated during MI.…”

Section: Discussionmentioning

confidence: 99%

The recruitment of indirect waves within primary motor cortex during motor imagery: A directional transcranial magnetic stimulation study

Neige

Ciechelski

Lebon

2022

Eur J of Neuroscience

View full text Add to dashboard Cite

Motor imagery (MI) refers to the mental simulation of an action without overt movement. While numerous transcranial magnetic stimulation (TMS) studies provided evidence for a modulation of corticospinal excitability and intracortical inhibition during MI, the neural signature within the primary motor cortex is not clearly established. In the current study, we used directional TMS to probe the modulation of the excitability of early and late indirect waves (I‐waves) generating pathways during MI. Corticospinal responses evoked by TMS with posterior–anterior (PA) and anterior–posterior (AP) current flow within the primary motor cortex evoke preferentially early and late I‐waves, respectively. Seventeen participants were instructed to stay at rest or to imagine maximal isometric contractions of the right flexor carpi radialis. We demonstrated that the increase of corticospinal excitability during MI is greater with PA than AP orientation. By using paired‐pulse stimulations, we confirmed that short‐interval intracortical inhibition (SICI) increased during MI in comparison to rest with PA orientation, whereas we found that it decreased with AP orientation. Overall, these results indicate that the pathways recruited by PA and AP orientations that generate early and late I‐waves are differentially modulated by MI.

show abstract

Breaking down the human motor cortex: the layer‐specific measurement of corticospinal neuronal activity

Cited by 2 publications

References 5 publications

The recruitment of indirect-waves within primary motor cortex during motor imagery: A directional Transcranial Magnetic Stimulation study

The recruitment of indirect-waves within primary motor cortex during motor imagery: A directional Transcranial Magnetic Stimulation study

The recruitment of indirect waves within primary motor cortex during motor imagery: A directional transcranial magnetic stimulation study

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