Breaking Down Barriers to Physical Activity in Patients with Nonalcoholic Fatty Liver Disease

Stine, Jonathan G.; Soriano, Christopher; Schreibman, Ian; Rivas, Gloriany; Hummer, Breianna; Schmitz, Kathryn H.; Sciamanna, Christopher N.

doi:10.1007/s10620-020-06673-w

Cited by 41 publications

(89 citation statements)

References 38 publications

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“…(6) Furthermore, when exercise is prescribed, many patients with chronic liver disease are unable to access fitness resources and receive insufficient education on how to safely and properly exercise. (7) The EL-FIT application offers a potential solution to this problem by providing a home-based exercise training program that is specific to patients with chronic liver disease and readily accessible through a smartphone or tablet computer. Importantly, this program is tailored to each individual's baseline fitness level, which is directly assessed by the application following patient input of requested data, and creates progressive difficulty of exercise as fitness level improves.…”

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confidence: 99%

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Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?

Faust

Stine

2021

Liver Transpl.

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confidence: 99%

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confidence: 99%

Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?

Faust

Stine

2021

Liver Transpl.

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“…Further confirming feasibility, fitness activity tracker compliance was excellent at 91%. This is important because previous studies have found only 1/3 of patients with NAFLD have used a fitness activity tracker in a real-world setting, supporting concerns about widespread use of this technology in this patient population [5].…”

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confidence: 92%

“…Even in a structured, highly supervised setting, weight loss goals are achieved by less than 10% of patients with NAFLD [4]. Moreover, 75% of patients with NAFLD will not achieve recommended amounts of physical activity despite almost all patients expressing desire to be more physically active [5].…”

mentioning

confidence: 99%

“…What prevents patients with NAFLD from successfully attaining lifestyle modification? Common self-identified barriers include a lack of education and healthy lifestyle resources, physical discomfort, time and cost [5]. Mobile health (mHealth) applications offer the promise of removing many of these self-identified barriers, enabling the achievement of successful lifestyle modification.…”

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confidence: 99%

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Time to Step It Up: Mobile Health Intervention for Lifestyle Modification in Patients with Nonalcoholic Fatty Liver Disease

Faust

Stine

2021

Dig Dis Sci

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High-Intensity Interval Training is Safe, Feasible and Efficacious in Nonalcoholic Steatohepatitis: A Randomized Controlled Trial

et al. 2022

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Background High-Intensity Interval Training (HIIT) involves bursts of high-intensity exercise interspersed with lower-intensity exercise recovery. HIIT may benefit cardiometabolic health in people with nonalcoholic steatohepatitis (NASH). Aims We aimed to examine the safety, feasibility, and efficacy of 12-weeks of supervised HIIT compared with a sham-exercise control (CON) for improving aerobic fitness and peripheral insulin sensitivity in biopsy-proven NASH. Methods Participants based in the community [( n = 14, 56 ± 10 years, BMI 39.2 ± 6.7 kg/m 2 , 64% male), NAFLD Activity Score 5 (range 3–7)] were randomized to 12-weeks of supervised HIIT ( n = 8, 4 × 4 min at 85–95% maximal heart rate, interspersed with 3 min active recovery; 3 days/week) or CON ( n = 6, stretching; 3 days/week). Safety (adverse events) and feasibility determined as ≥ 70% program completion and ≥ 70% global adherence (including session attendance, interval intensity adherence, and duration adherence) were assessed. Changes in cardiorespiratory fitness (V̇O 2 peak), exercise capacity (time-on-test) and peripheral insulin sensitivity (euglycemic hyperinsulinemic clamp) were assessed. Data were analysed using ANCOVA with baseline value as the covariate. Results There were no HIIT-related adverse events and HIIT was globally feasible [program completion 75%, global adherence 100% (including adherence to session 95.4 ± 7.3%, interval intensity 95.3 ± 6.0% and duration 96.8 ± 2.4%)]. A large between-group effect was observed for exercise capacity [mean difference 134.2 s (95% CI 19.8, 248.6 s), ƞ 2 0.44, p = 0.03], improving in HIIT (106.2 ± 97.5 s) but not CON (− 33.4 ± 43.3 s), and for peripheral insulin sensitivity [mean difference 3.4 mg/KgLegFFM/min (95% CI 0.9,6.8 mg/KgLegFFM/min), ƞ 2 0.32, p = 0.046], improving in HIIT (1.0 ± 0.8 mg/KgLegFFM/min) but not CON (− 3.1 ± 1.2 mg/KgLegFFM/min). Conclusions HIIT is safe, feasible and efficacious for improving exercise capacity and peripheral insulin sensitivity in people with NASH. Clinical Trial Registration Number Australian New Zealand Clinical Trial Registry (anzctr.org.au) identifier ACTRN12616000305426 (09/03/2016). Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s10620-022-07779-z.

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Breaking Down Barriers to Physical Activity in Patients with Nonalcoholic Fatty Liver Disease

Cited by 41 publications

References 38 publications

Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?

Leveraging the Coronavirus Disease 2019 Pandemic: Is It Time to Consider Incorporating Mobile Applications Into Standard Clinical Management of the Liver Transplantation Patient?

Time to Step It Up: Mobile Health Intervention for Lifestyle Modification in Patients with Nonalcoholic Fatty Liver Disease

High-Intensity Interval Training is Safe, Feasible and Efficacious in Nonalcoholic Steatohepatitis: A Randomized Controlled Trial

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