Breaking Down Barriers in Drug Delivery by Stromal Remodeling Approaches in Pancreatic Cancer
Ying Zhou,
Yunxiao Ma,
Jianwei Sheng
et al.
Abstract:Pancreatic cancer remains a formidable challenge in oncology due to its aggressive nature and limited treatment options. The dense stroma surrounding pancreatic tumors not only provides structural support but also presents a formidable barrier to effective therapy, hindering drug penetration and immune cell infiltration. This review delves into the intricate interplay between stromal components and cancer cells, highlighting their impact on treatment resistance and prognosis. Strategies for stromal remodeling,… Show more
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