Breakdown and repair of the aging brain metabolic system
Polina Shichkova,
Jay S. Coggan,
Lida Kanari
et al.
Abstract:Cognitive impairments and neurodegeneration in aging are linked to disrupted brain energy metabolism. We address this experimentally challenging problem with a computational molecular model that provides mechanistic insights and therapeutic predictions. This model encompasses key enzymes, transporters, metabolites, and other important factors, enabling the investigation of over 66,000 molecular interactions within and across cellular and subcellular compartments of neurons, glia, and blood vessels. During agin… Show more
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