Breakage-Facilitated Mixed-Suspension-Mixed-Product-Removal (MSMPR) Crystallization of Pharmaceutical Compounds
Fan Liu,
Huayu Li,
Yuantao Li
Abstract:Continuous crystallization provides advantages of producing solid products of consistent quality attributes at a small equipment footprint. However, the intrinsic nucleation and growth rates of small-molecule pharmaceuticals constrain the design spaces of their continuous crystallization processes. In this work, a wet milling device, breaking large particles into small fragments, was incorporated into a mixed-suspension-mixed-product-removal (MSMSR) single-stage crystallizer. The MSMPR crystallization was cont… Show more
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