Breakage and drying behaviour of granules in a continuous fluid bed dryer: Influence of process parameters and wet granule transfer

Leersnyder, Fien De; Vanhoorne, Valérie; Bekaert, H.; Vercruysse, Jurgen; Ghijs, Michaël; Bostijn, N.; Verstraeten, Maxim; Cappuyns, Philippe; Assche, Ivo Van; Heyden, Yvan Vander; Ziemons, Eric; Remon, Jean‐Paul; Nopens, Ingmar; Vervaet, Chris; Beer, Thomas De

doi:10.1016/j.ejps.2018.01.037

Cited by 51 publications

(45 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(19) After drying, the breakage of the material through pneumatic transport through a tube to the evaluation module is calculated by a PBM. As aggregation is assumed not to take place based on the experimental work of De Leersnyder et al [14], only the last two terms in the right hand side of Equation (8) need to be used. The same breakage kernel as in the kneading zone of the TSWG was found to apply, i.e., breakage rate S(ε) from Equation (10) and breakage fragment distribution b(x, ε) from Equation (11).…”

Section: Twin-screw Wet Granulatormentioning

confidence: 99%

See 1 more Smart Citation

Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

et al. 2019

View full text Add to dashboard Cite

In view of growing interest and investment in continuous manufacturing, the development and utilization of mathematical model(s) of the manufacturing line is of prime importance. These models are essential for understanding the complex interplay between process-wide critical process parameters (CPPs) and critical quality attributes (CQAs) beyond the individual process operations. In this work, a flowsheet model that is an approximate representation of the ConsiGma TM -25 line for continuous tablet manufacturing, including wet granulation, is developed. The manufacturing line involves various unit operations, i.e., feeders, blenders, a twin-screw wet granulator, a fluidized bed dryer, a mill, and a tablet press. The unit operations are simulated using various modeling approaches such as data-driven models, semi-empirical models, population balance models, and mechanistic models. Intermediate feeders, blenders, and transfer lines between the units are also simulated. The continuous process is simulated using the flowsheet model thus developed and case studies are provided to demonstrate its application for dynamic simulation. Finally, the flowsheet model is used to systematically identify critical process parameters (CPPs) that affect process responses of interest using global sensitivity analysis methods. Liquid feed rate to the granulator, and air temperature and drying time in the dryer are identified as CPPs affecting the tablet properties.

show abstract

Section: Twin-screw Wet Granulatormentioning

confidence: 99%

“…Specifically, the units involved are feeders, blenders, twin-screw wet granulator (TSWG), fluid bed dryer (FBD), comill, and tablet press. Models for these processes are developed [12][13][14][15][16] and included. Besides these, models for intermediate feeding and blending operations are also included.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In this work, the process of fluidised bed drying is focused on and, more particularly, the moisture reduction of pharmaceutical granules. Particle size has also been found to contribute significantly to the process efficiency (De Leersnyder et al, 2018), yet a detailed assessment of the output and process regimes in function of equipment settings remains undisclosed. Therefore, a method is devised for simultaneous determination of particulate size and chemical composition (moisture content) of as many individual entities as possible of the granule population, which allows to map the two-dimensional distribution of these properties.…”

Section: Introductionmentioning

confidence: 99%

Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed drying using near-infrared chemical imaging

Ghijs

Vanbillemont

Nicolaï

et al. 2021

International Journal of Pharmaceutics

View full text Add to dashboard Cite

“…The effect of critical CPPs on the CQAs of the fluidized bed has been studied. Leersnyer et al studied the breakage and attrition phenomena during fluidized bed drying and after granulation in a continuous twin screw granulator. It was discovered that the breakage of the granules occurred within the first seconds of drying.…”

Section: Introductionmentioning

confidence: 99%

Continuous fluidized bed drying: Residence time distribution characterization and effluent moisture content prediction

et al. 2020

View full text Add to dashboard Cite

The mixing and drying behavior in a continuous fluidized bed dryer were investigated experimentally by characterizing the residence time distribution (RTD) and incorporating a micromixing model together with the drying kinetics obtained from batch drying. The RTD of the dryer was modeled using a tank‐in‐series model. It was found that a high initial material loading and a low material flow rate resulted in a reduced peak height and broaded peak width of the RTD curve. To predict the continuous dryer effluent moisture content, we combined: (a) the drying kinetics as determined in a batch fluidized bed dryer, (b) the RTD model, and (c) micromixing models—segregation and maximum mixedness models. It was found that the segregation model overpredicted the effluent moisture content by up to 5% for the cases we have studied while the maximum mixedness model gave a good prediction of the effluent moisture content.

show abstract

Breakage and drying behaviour of granules in a continuous fluid bed dryer: Influence of process parameters and wet granule transfer

Cited by 51 publications

References 17 publications

Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

Dynamic Flowsheet Model Development and Sensitivity Analysis of a Continuous Pharmaceutical Tablet Manufacturing Process Using the Wet Granulation Route

Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed drying using near-infrared chemical imaging

Continuous fluidized bed drying: Residence time distribution characterization and effluent moisture content prediction

Contact Info

Product

Resources

About