BRD4 Protein as a Target for Lung Cancer and Hematological Cancer
Therapy: A Review
Mengmeng Zhang,
Yingbo Li,
Zilong Zhang
et al.
Abstract:The BET protein family plays a crucial role in regulating the epigenetic landscape of
the genome. Their role in regulating tumor-related gene expression and its impact on the survival
of tumor cells is widely acknowledged. Among the BET family constituents, BRD4 is a significant protein. It is a bromodomain-containing protein located at the outer terminal that recognizes
histones that have undergone acetylation. It is present in the promoter or enhancer region of the target gene and is responsible for initiati… Show more
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