Abstract:Breast cancer (BC) remains one of the leading causes of death in Background: women worldwide. The deleterious mutation has a significant role in BRCA1 developing BC, and the risk has been estimated to be 46-87%. Many studies emphasize the need for mining gene mutations that might have a role BRCA1 in BC pathogenesis and could affect early disease onset. This study was conducted to screen for possible pathogenic single nucleotide polymorphisms (SNPs) in , targeting three regions: two in exon 11 and the third in… Show more
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