BRAZILIN PROTECTS CULTURED RAT HEPATOCYTES FROM BrCCI<sub>3</sub>-INDUCED TOXICITY

Moon, Chang-Kiu; Park, Kwangsik; Kim, Seong‐Gon; Won, Hyeon-Soon; Chung, Jin

doi:10.3109/01480549209035174

Cited by 63 publications

(32 citation statements)

References 12 publications

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“…Brasilin was originally isolated from C. echinata Lam (Brazil-wood) and C. sappan (sappan-wood). This compound has been reported to have various biological activities including antiinflammatory activity (Hikino et al, 1977), antioxidative activity (Moon et al, 1992), hypoglycemic activity (Kim et al, 1995) and immune function modulating effects Choi and Moon, 1997). Our results clearly show that brasilin is also an antibacterial agent.…”

Section: Discussionsupporting

confidence: 61%

The antibacterial principle of Caesalpina sappan

Lee

2004

Phytotherapy Research

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Using a bioassay-directed purification scheme, the active antibacterial principle from Caesalpina sappan was isolated and identified to be brasilin. This compound showed potent activity against antibiotic-resistant bacteria, notably methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), multi-drug resistant Burkholderia cepacia as well as a number of other bacteria. The minimal inhibitory concentrations ranged from 4 to 32 microg/mL. The results from time-kill studies showed that brasilin is bactericidal against MRSA. The addition of brasilin to growing MRSA cells resulted in a rapid inhibition of incorporation of [(3)H] thymidine or [(3)H] serine into DNA and proteins, respectively. Exposure of MRSA to a sub-MIC level of brasilin for ten consecutive subcultures did not induce resistance to the compound. The Trypan blue dye exclusion test showed that brasilin lacked cytotoxicity against Vero cells. In conclusion, brasilin is an antibacterial principle from C. sappan and it has the potential to be developed into an antibiotic.

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Section: Discussionsupporting

confidence: 61%

The antibacterial principle of Caesalpina sappan

Lee

2004

Phytotherapy Research

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“…Brazilin (in SFN) has been reported to have many biological activities, including immune regulation, 19,20 blood vessel dilatation, 3,11,14 anticoagulation, 8,17 hypoglycemic effect, 10,13,15,16,26,27 oxidative damage inhibition, 6,28 antibiosis, 9 and anti-inflammatory effects. 4,5,7 In addition, it was demonstrated that brazilin powerfully broke deoxynucleic acid chains in anticancer screening.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Su Fu’ning Lotion’s Inhibitory Effects on Bladder Cancer Cells In Vitro and In Vivo by Intravesical Instillation

et al. 2015

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Background. Bladder cancer is a common malignant tumor with a very high recurrence rate after surgery. Intravesical instillation can help clear up the residual tumor cells after surgery and thereby reduce the recurrence rate. Objective. To establish a bladder tumor transplantation animal model and to evaluate the inhibitory effects of a novel perfusate, Su Fu'ning Lotion (SFN), on bladder tumor. Methods. SFN was compared with several commonly used chemotherapy drugs, including mitomycin (MMC) and pirarubicin (THP) for anticancer effects on the bladder cancer cell lines T24, BTT, and BIU-87 and SFN half inhibitory concentrations (IC 50 ) were determined after 48 hours of treatment. In addition, bladder cancer orthotopic transplantation tumor models were established in BALB/C nude mice and T739 mice, and SFN anticancer effects were assessed in vivo, with normal saline and MMC as negative and positive controls, respectively. Results. SFN, MMC, and THP were all lethal to bladder cancer cells, in vitro, with SFN and THP significantly superior to MMC. IC 50 values for SFN were 13.22, 11.22, and 12.5 µg/mL on T24, BTT, and BIU-87 cells, respectively. In vivo, SFN significantly reduced the mouse bladder wet weight and prolonged the animal survival compared with controls (P < .05), suggesting that SFN significantly inhibited T24/BTT cell growth in mice. Conclusion. SFN inhibited the bladder cancer cell proliferation in vitro and in vivo and significantly prolonged the survival of mice with bladder cancer xenografts, indicating that SFN could be used as a perfusate after surgery for removal of residual bladder cancers cells.

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“…Wu et al; [40] Wang et al [22] Hypoglycemic activity Modulation of insulin receptor Lee et al; [41] Kim et al [ [47] Srilakshami et al [21] …”

Section: Cox-2 Inhibitionmentioning

confidence: 99%

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Nirmal

Rajput

Prasad³

et al. 2015

Asian Pacific Journal of Tropical Medicine

227

153

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Caesalpinia sappan L. (CS) is a plant of Leguminosae family, commonly known as Brazil or Sappan wood. CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverages and has a wide variety of medicinal properties. Higher extraction yield of CS wood was achieved with 95% ethanol for 2 h. Chemical constituent's investigation of sappan wood resulted in the isolation of various structural types of phenolic components including one xanthone, one coumarin, three chalcones, two flavones three homoisoflavonoids and brazilin. Brazilin [(6a S-cis)-7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)- tetrol], a major and active compound found in CS heartwood. Most of the folkloric uses of brazilin were validated by the scientific studies such as antioxidant, antibacterial, anti-inflammatory, anti-photoaging, hypoglycemic, vasorelaxant, hepatoprotective and anti-acne activity. CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats. Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food, beverage, cosmetics and pharmaceutical industries to screen its clinical use in modern medicine. The information gained could provide the important and potential approach for pharmaceutical researcher to implicate the knowledge of brazilin in the formulation of new drug and to reveal therapeutic and gaps requiring future research opportunities. More studies are needed to evaluate the potential application of brazilin as preservative and coloring agent in food processing industries.

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BRAZILIN PROTECTS CULTURED RAT HEPATOCYTES FROM BrCCI₃-INDUCED TOXICITY

Cited by 63 publications

References 12 publications

The antibacterial principle of Caesalpina sappan

The antibacterial principle of Caesalpina sappan

Evaluation of Su Fu’ning Lotion’s Inhibitory Effects on Bladder Cancer Cells In Vitro and In Vivo by Intravesical Instillation

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

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BRAZILIN PROTECTS CULTURED RAT HEPATOCYTES FROM BrCCI3-INDUCED TOXICITY

Cited by 63 publications

References 12 publications

The antibacterial principle of Caesalpina sappan

The antibacterial principle of Caesalpina sappan

Evaluation of Su Fu’ning Lotion’s Inhibitory Effects on Bladder Cancer Cells In Vitro and In Vivo by Intravesical Instillation

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

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BRAZILIN PROTECTS CULTURED RAT HEPATOCYTES FROM BrCCI₃-INDUCED TOXICITY