Brazilian normal static bone histomorphometry: effects of age, sex, and race

Reis, Luciene M. dos; Batalha, Joao R. F.; Muñoz, Daniel Romero; Borelli, A; Corrêa, Pedro Henrique Silveira; Carvalho, Aluízio Barbosa de; Jorgetti, Vanda

doi:10.1007/s00774-007-0778-4

Cited by 51 publications

(22 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Histomorphometric parameters were those suggested by the American Society of Bone and Mineral Research histomorphometry nomenclature committee [20]. Reference values (RV) used for static parameters were obtained from local controls [21], whereas dynamic parameters followed those described elsewhere [22]. …”

Section: Patients and Methods Patientsmentioning

confidence: 99%

The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study

et al. 2017

View full text Add to dashboard Cite

Parathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction of bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed to prospectively investigate the impact of PTX on bone remodeling and its potential consequence on the progression of VC in hemodialysis patients. In this prospective study, 19 hemodialysis patients with severe secondary hyperparathyroidism (sHPT) were evaluated. All patients underwent laboratorial tests and coronary tomography at baseline and, 6 and 12 months after PTX; bone biopsy was performed at baseline and 12-month. At baseline, all patients had increased PTH levels up to 2500 pg/mL and high turnover bone disease in their bone biopsies. Fourteen (74%) patients had VC. During the follow-up, there was a significant decrease of PTH at 6 and 12-month. At 12-month, 90% of the patients evolved to low turnover bone disease. During the period of the hungry bone syndrome (first 6 months), no change of coronary calcium score was observed. However, calcium score increased significantly thereafter (12th month). There was an association between VC progression and the severity of low turnover bone disease. In conclusion, the shift from high to low turnover bone disease after PTX occurs in parallel to VC progression, contributing to the understanding of the complex pathophysiology involving mineral metabolism and cardiovascular disease in hemodialysis patients.

show abstract

Section: Patients and Methods Patientsmentioning

confidence: 99%

The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…We used the histomorphometric parameters suggested by the American Society of Bone and Mineral Research histomorphometry nomenclature committee [16]. The reference ranges for static parameters were obtained from local controls [17], whereas the dynamic parameters followed those described elsewhere [18]. …”

Section: Methodsmentioning

confidence: 99%

Phosphate Binder Impact on Bone Remodeling and Coronary Calcification – Results from the BRiC Study

et al. 2008

Self Cite

View full text Add to dashboard Cite

Backgroundand Aims: Calcium-containing phosphate binders have been shown to increase the progression of vascular calcification in hemodialysis patients. This is a prospective study that compares the effects of calcium acetate and sevelamer on coronary calcification (CAC) and bone histology. Methods: 101 hemodialysis patients were randomized for each phosphate binder and submitted to multislice coronary tomographies and bone biopsies at entry and 12 months. Results: The 71 patients who concluded the study had similar baseline characteristics. On follow-up, the sevelamer group had higher levels of intact parathyroid hormone (498 ± 352 vs. 326 ± 236 pg/ml, p = 0.017), bone alkaline phosphatase (38 ± 24 vs. 28 ± 15 U/l, p = 0.03) and deoxypyridinoline (135 ± 107 vs. 89 ± 71 nmol/l, p = 0.03) and lower LDL cholesterol (74 ± 21 vs. 91 ± 28 mg/dl, p = 0.015). Phosphorus (5.8 ± 1.0 vs. 6 ± 1.0 mg/dl, p = 0.47) and calcium (1.27 ± 0.07 vs. 1.23 ± 0.08 mmol/l, p = 0.68) levels did not differ between groups. CAC progression (35 vs. 24%, p = 0.94) and bone histological diagnosis at baseline and 12 months were similar in both groups. Patients of the sevelamer group with a high turnover at baseline had an increase in bone resorption (eroded surface, ES/BS = 9.0 ± 5.9 vs. 13.1 ± 9.5%, p = 0.05), whereas patients of both groups with low turnover at baseline had an improvement in bone formation rate (BFR/BS = 0.015 ± 0.016 vs. 0.062 ± 0.078, p = 0.003 for calcium and 0.017 ± 0.016 vs. 0.071 ± 0.084 μm³/μm²/day, p = 0.010 for sevelamer). Conclusions: There was no difference in CAC progression or changes in bone remodeling between the calcium and the sevelamer groups.

show abstract

“…Mineralization defect was defined as an MLT ≥50 days. Volume was defined as normal when the BV/TV values were between -1 and +1 SD, high when the BV/TV values were greater than +1 SD, and low when the BV/TV values were lower than -1 SD of the mean reference values (men, n = 47: 24.0±6.1; women, n = 40: 21.8±7.2) [16]. …”

Section: Methodsmentioning

confidence: 99%

Renal osteodystrophy in the obesity era: Is metabolic syndrome relevant?

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundObservational studies have shown a beneficial effect of obesity on bone health; however, most of those studies were not based on bone biopsies. Metabolic syndrome (MetS) could have an effect on bone remodeling. However, there are no data on the effects of MetS in the presence of renal osteodystrophy.ObjectiveThe aim of this study was to investigate associations between MetS and renal osteodystrophy using the bone histomorphometric turnover-mineralization-volume (TMV) classification.Design, setting, participants & measurementsThis observational cross-sectional study included 55 hemodialysis patients (28 women/27 men) who were evaluated for MetS and bone histomorphometry. Biochemical parameters included calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (iPTH), 25-hydroxyvitamin D, free serum leptin, fibroblast growth factor 23 (FGF23), intact osteocalcin, sclerostin (Scl), glucose, insulin, and thyroid hormones. Robust models of multivariate linear regressions were used for the statistical analyses.ResultsFemales had higher iPTH levels (1,143 vs. 358, p = 0.02). Patients with normal bone volume (BV/TV) had a higher prevalence of MetS (73.6% vs. 41.7%, p = 0.02) and higher serum phosphorus, C-terminal FGF23 and insulin levels. The multivariate regression analysis showed that low-density lipoprotein cholesterol (LDL) was positively correlated with bone formation rate (BFR/BS) and negatively associated with mineralization lag time. Bone volume was negatively associated with age but positively associated with MetS. Body mass index (BMI) was not correlated with any of the bone histomorphometric parameters.ConclusionOur results suggest that MetS is not a risk factor for low bone volume in hemodialysis patients. Furthermore, BMI alone was not related to bone volume in this population.

show abstract

Brazilian normal static bone histomorphometry: effects of age, sex, and race

Cited by 51 publications

References 27 publications

The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study

The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study

Phosphate Binder Impact on Bone Remodeling and Coronary Calcification – Results from the BRiC Study

Renal osteodystrophy in the obesity era: Is metabolic syndrome relevant?

Contact Info

Product

Resources

About