Brazil Nut Supplementation Does Not Regulate PPARβ/δ Signaling Pathway in Peripheral Blood Mononuclear Cells from Coronary Artery Disease Patients

Cruz, Beatriz; Cardozo, Ludmila F M F; Coutinho-Wolino, Karen Salve; Mesquita, Cláudio Tinoco; Leal, Viviane O.; Mafra, Denise; Stockler‐Pinto, Milena Barcza

doi:10.1080/07315724.2021.1963882

Cited by 4 publications

(8 citation statements)

References 46 publications

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“…Approximately 93% of the publications were from research conducted in Brazil between 2008 and 2022. Thirteen [ 17 , 19 , 20 , 21 , 22 , 26 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] of the twenty-four studies included in this systematic review are new compared to the review carried out by Cardoso et al (2017).…”

Section: Resultsmentioning

confidence: 99%

“…Of the twenty-four, nine publications were the results of randomized clinical trials. Of these, two studies were placebo-controlled [ 14 , 15 ], seven were controlled [ 16 , 17 , 18 , 19 , 20 , 21 , 22 ], and sixteen were non-randomized clinical trials. Only two non-randomized studies were controlled [ 23 ], whereas all others were uncontrolled [ 14 , 15 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

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Effects of Regular Brazil Nut (Bertholletia excelsa H.B.K.) Consumption on Health: A Systematic Review of Clinical Trials

Silva

Silveira

Freitas

et al. 2022

Foods

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The Brazil nut (BN) is a promising food due to its numerous health benefits, but it is still necessary to systematically review the scientific evidence on these benefits. Thus, we examined the effects of regular BN consumption on health markers in humans according to the health state (with specific diseases or not) of the subjects. PubMed, Embase®, and Scielo databases were used to search for clinical trials. The PRISMA guideline was used to report the review, and the risk of bias for all studies was assessed. Twenty-four studies were included in the present review, of which fifteen were non-randomized. BNs were consumed in the context of a habitual free-living diet in all studies. Improvement in antioxidant status through increased levels of selenium and/or glutathione peroxidase activity in plasma, serum, whole blood, and/or erythrocytes was observed in all studies that evaluated antioxidant status, regardless of the health state of the sample. In addition, healthy subjects improved lipid markers and fasting glucose. Subjects with obesity had improvement in markers of lipid metabolism. Subjects with type 2 diabetes mellitus or dyslipidemia improved oxidative stress or DNA damage. Subjects undergoing hemodialysis benefited greatly from BN consumption, as they improved lipid profile markers, oxidative stress, inflammation, and thyroid function. Older adults with mild cognitive impairment improved verbal fluency and constructional praxis, and controversial results regarding the change in a marker of lipid peroxidation were observed in subjects with coronary artery disease. In conclusion, the benefits of BN consumption were found in different pathways of action and study populations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Effects of Regular Brazil Nut (Bertholletia excelsa H.B.K.) Consumption on Health: A Systematic Review of Clinical Trials

Silva

Silveira

Freitas

et al. 2022

Foods

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“…Thus, 47 patients with a previous diagnosis of CAD that were evaluated by a doctor or patients without a previous diagnosis of CAD but had abnormal myocardial findings (myocardial ischemia and/or fibrosis), which was assessed by myocardial perfusion scintigraphy, were included in the study by a convenience sampling. Details about convenience sampling have been published previously (da Cruz et al, 2021). Briefly, convenience sampling is considered a non‐probability sampling method characterized by recruiting conveniently available subjects for the study who meet the inclusion criteria.…”

Section: Methodsmentioning

confidence: 99%

“…According to the chemical composition, the supplement of one Brazil nut (≈5 g) used in this study (donated by Agropecuária Arauanã S/A—Itacoatiara, Amazonas, Brazil) contained 36.7 kcal, 290.5 μg of selenium, 0.75 g of protein, 0.45 g of carbohydrates, 3.53 g of lipids and 177.47 mg total phenolic compounds expressed as gallic acid equivalents (GAE) (da Cruz et al, 2021; Stockler‐Pinto et al, 2010). Moreover, one Brazil nut daily utilized in this study meets the selenium recommendations, which is 55 μg for healthy individuals (Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds, 2000).…”

Section: Methodsmentioning

confidence: 99%

“…According to the chemical composition, the supplement of one Brazil nut (≈5 g) used in this study (donated by Agropecuária Arauanã S/A-Itacoatiara, Amazonas, Brazil) contained 36.7 kcal, 290.5 μg of selenium, 0.75 g of protein, 0.45 g of carbohydrates, 3.53 g of lipids and 177.47 mg total phenolic compounds expressed as gallic acid equivalents (GAE) (da Cruz et al, 2021;Stockler-Pinto et al, 2010).…”

Section: Me Thodsmentioning

confidence: 99%

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Brazil nut supplementation does not affect trimethylamine‐n‐oxide plasma levels in patients with coronary artery disease

Coutinho-Wolino

Cruz

Cardozo

et al. 2022

Journal of Food Biochemistry

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The purposes of this study were to assess the effect of Brazil nut supplementation on trimethylamine N‐oxide (TMAO) levels and glutathione peroxidase (GPx) activity in patients with coronary artery disease (CAD). Patients with CAD were randomly assigned to two groups, Brazil nut group (23 patients, 48% male, 62.7 ± 6.8 years, 29.4 ± 5.8 kg/m2), which received one Brazil nut per day for 3 months, and the control group (14 patients, 43% male, 63.7 ± 8.7 years, 28.4 ± 4.2 kg/m2) who did not receive any supplementation. After 3 months, TMAO levels and their precursors did not change in either group. Although not significant, GPx activity increased by 41% in the Brazil nut group. TMAO levels were negatively associated with total fiber intake (r = −0.385 and p = .02). A 3‐month Brazil nut supplementation did not change TMAO levels and GPx activity in CAD patients. Practical applications Trimethylamine N‐oxide (TMAO) has been associated with oxidative stress and cardiovascular disease risk. Thus, the increase in antioxidants enzymes production could be a promising strategy to reduce TMAO‐mediated oxidative stress. In this context, nutritional strategies are well‐known as activators of cellular antioxidant responses. As Brazil nuts have a known role in reducing oxidative stress by increasing glutathione peroxidase (GPx) activity (a selenium‐dependent antioxidant enzyme), this study hypothesized that Brazil nuts could be a strategy that, via antioxidant capacity, would reduce TMAO plasma levels. Although no changes in TMAO levels and GPx activity can be observed in this study, it is believed that other results can be obtained depending on the dosage used. Thus, this study can open new paths and direct other studies with different doses and treatment times to evaluate the effects of Brazil Nuts on TMAO levels.

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Brazil nut (Bertholletia excelsa H.B.K.) and Brazil nut oil: effects on oxidative stress and potential therapeutic health benefits from human, animal, and cell culture models

de Araújo,

de Campos,

Souza

et al. 2024

Nutrition Reviews

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Brazil nut (Bertholletia excelsa H.B.K.) is characterized by its high nutritional and energetic value. It contains high levels of l-arginine, antioxidant vitamins, phenolic compounds, and phytosterols. In addition to their biological functions, bioactive compounds and essential fatty acids present therapeutic effects on chronic disease prevention through their antioxidant effects. Thus, this review aims to present the most recent scientific evidence on the effect of Brazil nut on human health. A search for scientific articles was carried out through the MEDLINE/PubMed, Science Direct, and LILACS databases, considering articles published between the years 2010 and 2023. The results showed that Brazil nuts and Brazil nut oil, when consumed regularly and associated with a balanced diet, can improve lipid profile, attenuate inflammatory response, and improve oxidative stress through increased activity and gene expression of antioxidant enzymes. However, further studies are recommended to better understand the mechanisms of action.

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Brazil Nut Supplementation Does Not Regulate PPARβ/δ Signaling Pathway in Peripheral Blood Mononuclear Cells from Coronary Artery Disease Patients

Cited by 4 publications

References 46 publications

Effects of Regular Brazil Nut (Bertholletia excelsa H.B.K.) Consumption on Health: A Systematic Review of Clinical Trials

Effects of Regular Brazil Nut (Bertholletia excelsa H.B.K.) Consumption on Health: A Systematic Review of Clinical Trials

Brazil nut supplementation does not affect trimethylamine‐n‐oxide plasma levels in patients with coronary artery disease

Brazil nut (Bertholletia excelsa H.B.K.) and Brazil nut oil: effects on oxidative stress and potential therapeutic health benefits from human, animal, and cell culture models

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