Brasilinolide A, a New Macrolide Antibiotic Produced by Nocardia brasiliensis: Producing Strain, Isolation and Biological Activity.

Abstract

A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM0406. The producer was identified as Nocardia brasiliensis. The antibiotic was only active against Aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. Brasilinolide A exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (MLR). Immunosuppressive agents which attack specific target sites of immunocompetentcells are good candidate for immunotherapy. The examples of useful drugs of this type are cyclosporin A1} and FK-5062). We had reported that some opportunistic pathogenic Nocardia, such as Nocardia otitidiscaviarum and Nocardia brasiliensis, produce novel bioactive substances3~5). In the course of continuing search for bioactive substances including immunosuppressive agents from Nocardia, we found

Three Types of Antibiotics Produced from Rhodococcus erythropolis Strains

“…Many Streptomyces species produce various antibiotics. Other genera in the phylum Actinobacteria, such as Actinomadura 2) , Arthrobacter 8) , and Nocardia 23) have also been reported to produce antibiotics, though they have not been studied extensively. In the last few decades, the genus Rhodococcus, a member of Actinobacteria, has received considerable attention for its remarkable ability to degrade persistent chemicals such as polychlorinated biphenyls (PCBs) 14,15) and nitrophenols 4,11) ; the industrial application of nitrile hydratase that is synthesized by the members of this genus 13) has also been investigated.…”

The complete genomic sequence of Nocardia farcinica IFM 10152

“…Another feature of the nocardia is that many strains, even clinical isolates, also have the capability to produce bioactive molecules such as antibiotics (4,5) and enzymes that are industrially important (6). A monobactam antibiotic, nocardicin, was isolated from Nocardia sp.…”

Microbiotechnology Based Surfactants and Their Applications

“…Endowed with nutritional and growth advantages toward surrounding organisms, surfactant producers can become rampant, and are often less affected by substances present during its growth, e.g., antimicrobial drugs. They have been found in patients that suffer from infections/diseases caused by human deficiency viruses (Guérardel et al, 2003), patients with lung infections and infections of the oral cavity (Datta and Takayama, 1993;Sutcliffe, 1995;Tanaka et al, 1997). In addition, biosurfactant-producing actinobacterial strains have also been isolated from infected plant tissue (Frahn et al, 1984).…”

“…The aliphatic macrolide antibiotic, brasilinolide, is produced by Nocardia brasiliensis and exhibits both antifungal and antibacterial activity. Three different variants have been described by Tanaka et al (1997), Mikami et al (2000) and Komatsu et al (2004). All consist of a C32-membered macrolide with a sugar moiety but differ with regards to the acylation site of a malonic acid ester side chain (11, Table 5).…”