Cosmologies with a Chaplygin gas have recently been explored with the objective of explaining the transition from a dust dominated epoch towards an accelerating expansion stage. We consider the hypothesis that the transition to the accelerated period involves a quantum mechanical process. Three physically admissible cases are possible. In particular, we identify a minisuperspace configuration with two Lorentzian sectors, separated by a classically forbidden region. The Hartle-Hawking and Vilenkin wave functions are computed, together with the transition amplitudes towards the accelerating epoch. Furthermore, it is found that for specific initial conditions, the parameters characterizing the generalized Chaplygin gas become related through an expression involving an integer n. We also introduce a phenomenological association between some brane-world scenarios and a FRW minisuperspace cosmology with a generalized Chaplygin gas. The aim is to promote a discussion and subsequent research on the quantum creation of brane cosmologies from such a perspective. Results suggest that the brane tension would become related with generalized Chaplygin gas parameters through another expression involving an integer.PACS numbers: 98.80.-k, 98.80.Qc