Brandisianones F and G from Millettia brandisiana Kurz and their cytotoxicity

Abstract

A new flavanone and a new chalcone, brandisianones F and G, were purified from the roots of Millettia brandisiana Kurz, moreover, sixteen known compounds were found. The chemical structures of all isolated compounds were identified using spectroscopic methods including 1D-NMR, 2D-NMR, MS and IR data. Chalcone 15 exhibited the most cytotoxic activity against liver cancer, HepG2, and cholangiocarcinoma, KKU-M156, cell lines with IC 50 values of 1.74 ± 0.91 and 1.95 ± 0.95 g/mL, respectively. Chalcones 2, 4, 16 and 18 as well as flavones 5, 6 and 12 showed moderate cytotoxicity with IC 50 values ranging from 5.39 to 14.00 g/mL.

Impact of Drying Processes on Phenolics and In Vitro Health-Related Activities of Indigenous Plants in Thailand

“…Unfortunately, no information on the α-amylase- and α-glucosidase-inhibitory activities of Mi. brandisiana was previously reported, with the focus on bioactive compounds contained in its roots [ 26 ]. Only isoflavones and brandisianins were identified in the leaves of Mi.…”

Inhibitory Activity of Flavonoid Scaffolds on SARS-CoV-2 3CLpro: Insights from the Computational and Experimental Investigations

“…Additionally, nine flavonoid derivatives from M. brandisiana Kurz including compounds 9 , 10 , 11 , 16 , 17 , 18 , genistein ( 20 ), isoprunetin ( 21 ), and formononetin ( 22 ) were isolated based on our previously published research. , The positive control baicalein was purchased from Sigma-Aldrich.…”

“…33 Additionally, nine flavonoid derivatives from M. brandisiana Kurz including compounds 9, 10, 11, 16, 17, 18, genistein (20), isoprunetin (21), and formononetin (22) were isolated based on our previously published research. 34,35 The positive control baicalein was purchased from Sigma-Aldrich. Six flavonoids, namely, pinocembrin (1), pinostrobin (2), alpinetin (3), cardamonin (14), pinostrobin chalcone (15), and panduratin A (19), were isolated from the rhizome of B. rotunda (L.) Mansf.…”

A theoretical screening of phytochemical constituents from Millettia brandisiana as inhibitors against acetylcholinesterase

“…In addition, recent studies discovered structurally distinct isoflavonoids in the various tissues of known Millettia species. [8][9][10][11][12][13][14][15][16] Prenylated isoflavonoids and rotenoids are the most frequently identified isoflavonoid subclasses. Other subclasses of isoflavonoids that have been found include, among others, isoflavans, aglycone isoflavones, glycosylated isoflavones, geranylated isoflavonoids, phenylcoumarins, pterocarpans and coumaronochromenes.…”

“…Although there are multiple substances extracted from MB, the molecular mechanisms of their medicinal activities are not well understood yet. 8,9,[11][12][13][14] In this context, we set out to investigate the structures and properties of a series of MB phytochemical components with the aim to screen their interaction features, and thereby their potential use as inhibitors against the AD enzymes, making use of computational approaches.…”