“…7 Two additional cases under visual vignettes highlighted the differential diagnosis of thyroid/neck masses due to hyperplastic thyroid nodule within the remnant pyramidal lobe and branchial cleft remnant. 8,9 On Diabetes, Lipid, and Metabolism, authors reported on two genetically confirmed cases of Wolfram Syndrome, a rare endoplasmic reticulum disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Highlighting the importance of considering monogenic diabetes genetic testing, including WFS1 gene, for patients with early-onset diabetes who are negative for islet autoantibodies and lean in order to offer proper management and improved quality of life in patients with this rare medical condition.…”