Branched thiocyclomalto-oligosaccharides: Synthesis and properties of 6-S-α- and 6-S-β-d-glucopyranosyl-6- thiocyclomaltoheptaose

Decreasing unnecessary utilization in acute bronchiolitis care: Results from the value in inpatient pediatrics network

“…Monovalent cyclodextrin neoglycoconjugates : The key precursor for the preparation of monobranched β ‐CD neoglycoconjugates is 6 I ‐deoxy‐6 I ‐ O‐para ‐tolylsulfonylcyclomaltoheptaose ( 1 ), for which we have recently reported an improved one‐step synthesis from β ‐CD 8. Its reactivity was first exploited by Defaye's group in the preparation of 6 I ‐ S ‐glycosyl‐6 I ‐thiocyclomaltoheptaose ( 4 ) by use of the sodium salt of 1‐thio‐ α ‐ and β ‐ D ‐glucopyranose as the nucleophile9 and was further extended to the synthesis of the analogous monovalent α ‐ and β ‐thiomaltosyl β ‐CD conjugates10 (Scheme ).…”

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate–protein interactions

“…[37][38][39][40][41][42] Tosylation at O-6 I is favored on steric grounds and, in the particular case of bCD when using aqueous media, by inclusion of the sulfonylating reagent in the cavity. This pathway competes, however, with tosylation at the more acidic O-2 position, which strongly complicates the purification step and represents a serious handicap for the final yield.…”

Multivalent Cyclooligosaccharides: Versatile Carbohydrate Clusters with Dual Role as Molecular Receptors and Lectin Ligands

“…[8] Its reactivity was first exploited by Defaye×s group in the preparation of 6 I -S-glycosyl-6 Ithiocyclomaltoheptaose (4) by use of the sodium salt of 1-thio-a-and b-d-glucopyranose as the nucleophile [9] and was further extended to the synthesis of the analogous monovalent aand b-thiomaltosyl b-CD conjugates [10] (Scheme 1).…”