Branched polyglycidol and its derivatives grafted-from poly(ethylene terephthalate) and silica as surfaces that reduce protein fouling

Utrata-Wesołek, Alicja; Wałach, Wojciech; Bochenek, Marcelina; Trzebicka, Barbara; Anioł, Jacek; Sieroń, Aleksander; Kubacki, Jerzy; Dworak, Andrzej

doi:10.1016/j.eurpolymj.2018.06.008

Cited by 15 publications

(12 citation statements)

References 47 publications

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“…observed a lower fibrinogen adsorption compared to uncoated NC, but hbPG even outperformed its linear analogue. [ 71 ] These findings could be ascribed to the superior surface coverage by the branched PG architecture.…”

Section: Bioinert and Stealth Surfacesmentioning

confidence: 99%

Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

Friedl

Nele

Rosa

et al. 2021

Adv Funct Materials

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Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote drug transport across membranes, to protect their payload from premature degradation, and to deliver drugs in a controlled and targeted manner. Their performance strongly depends on the surface chemistry, which governs their interaction with the biological environment. Bioinert and stealth surface features are advantageous to avoid unintended interactions with endogenous surfaces at off‐target sites and with the immune system, whereas at the target site these carriers should be highly interactive guaranteeing intracellular delivery of their payload. These key surface properties—bioinert and stealth versus interactive at the target site—are in contradiction to each other so that the best compromise between them has to be found. Alternatively, surface structures interacting preferentially with the membrane of target cells can be utilized. Stimuli‐responsive surfaces able to convert from bioinert and stealth to interactive at the target site have been recently introduced. A deepened understanding of how these different approaches influence the performance of NCs in the body is of particular importance in order to improve their efficacy. This review focuses on the surface chemistry of NCs providing the best compromise between bioinert and stealth versus interactive features.

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Section: Bioinert and Stealth Surfacesmentioning

confidence: 99%

Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

Friedl

Nele

Rosa

et al. 2021

Adv Funct Materials

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“…Layers of star (co)polymers ( Figure 8 b) of OEGMA with DEGMA and glycidyl methacrylate (GMA) [ 65 , 72 ], DMAEMA [ 108 ] and hyperbranched polyglycidol ( Figure 8 c) [ 109 ] were prepared. Star (co)polymers were linked to the support by the “grafting to” method [ 65 , 72 , 108 ], while hyperbranched polyglycidol was linked by “grafting from” [ 109 ]. A schematic description of the properties of the obtained layers is provided in Table 3 .…”

Section: Polymer Nano- and Microstructurementioning

confidence: 99%

“…Additionally, the hydroxyl groups of immobilized hyperbranched polyglycidol were modified with hydrophilic poly(ethylene glycol) chains or hydrophobic ethyl carbamate groups to study the influence of such modification on protein adsorption. All hyperbranched polyglycidol-based layers were able to reduce fibrinogen adsorption by approximately 45–90% compared with bare supports [ 109 ]. The effectiveness in resisting protein adsorption depended on the grafting density, the type of modification of the peripheral polyglycidol hydroxyl groups and on the base materials onto which the polymer was grafted.…”

Section: Polymer Nano- and Microstructurementioning

confidence: 99%

The Role of Polymer Structure in Formation of Various Nano- and Microstructural Materials: 30 Years of Research in the Laboratory of Nano- and Microstructural Materials at the Centre of Polymer and Carbon Materials PAS

et al. 2021

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The review summarizes the research carried out in the Laboratory of Nano- and Microstructural Materials at the Centre of Polymer and Carbon Materials, Polish Academy of Sciences (CMPW PAS). Studies carried out for many years under the guidance of Professor Andrzej Dworak led to the development and exploration of the mechanisms of oxirane and cyclic imine polymerization and controlled radical polymerization of methacrylate monomers. Based on that knowledge, within the last three decades, macromolecules with the desired composition, molar mass and topology were obtained and investigated. The ability to control the structure of the synthesized polymers turned out to be important, as it provided a way to tailor the physiochemical properties of the materials to their specific uses. Many linear polymers and copolymers as well as macromolecules with branched, star, dendritic and hyperbranched architectures were synthesized. Thanks to the applied controlled polymerization techniques, it was possible to obtain hydrophilic, hydrophobic, amphiphilic and stimulus-sensitive polymers. These tailor-made polymers with controlled properties were used for the construction of various types of materials, primarily on the micro- and nanoscales, with a wide range of possible applications, mainly in biomedicine. The diverse topology of polymers, and thus their properties, made it possible to obtain various types of polymeric nanostructures and use them as nanocarriers by encapsulation of biologically active substances. Additionally, polymer layers were obtained with features useful in medicine, particularly regenerative medicine and tissue engineering.

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“…The most frequently studied polymers containing zwitterions are poly(sulfobetaine), poly(carboxybetaine), and poly(phosphorylcholine) [131,132]. Hydrophilic materials that prevent surface biofouling include PEG, oligo(ethylene glycol)s, poly(methacrylates of ethylene glycol), polyacrylamides, polysaccharides, and polyglycidol [132][133][134][135][136][137].…”

Section: Antifouling Surfacesmentioning

confidence: 99%

Polymers in medicine direction of development

et al. 2019

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The paper constitutes a brief and subjective review of polymeric materials in the contemporary health service. The range of applications of polymeric materials is discussed, special att ention being paid to such materials for the development of carriers of pharmaceutically active species, stents and vascular prostheses, amongst them to the application of "smart" materials for these purposes, layers and scaff olds for the growth of organs and tissues, antifouling layers. The authors try to turn the att ention of the reader to the research and intellectual eff orts necessary for the development of polymeric materials for the medicine, and conclude about the growing importance of such studies.

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Branched polyglycidol and its derivatives grafted-from poly(ethylene terephthalate) and silica as surfaces that reduce protein fouling

Cited by 15 publications

References 47 publications

Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

Bioinert, Stealth or Interactive: How Surface Chemistry of Nanocarriers Determines Their Fate In Vivo

The Role of Polymer Structure in Formation of Various Nano- and Microstructural Materials: 30 Years of Research in the Laboratory of Nano- and Microstructural Materials at the Centre of Polymer and Carbon Materials PAS

Polymers in medicine direction of development

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