Branched PLGA derivatives with tailored drug delivery properties

Snejdrova, Eva; Podzimek, Štěpán; Martiska, Juraj; Holas, Ondřej; Dittrich, Milan

doi:10.2478/acph-2020-0011

Cited by 16 publications

(13 citation statements)

References 26 publications

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“…where f represents the number of random length arms in star polymers and f can be directly calculated from g 0 . The limitation here is that g 0 is derived for long Gaussian coils, which may not be applicable in the case of smaller branched macromolecules (Snejdrova et al, 2020). Branched initiators must be well esterified; the degree of PLGA esterification is determined using 13 C NMR, based on the peak shift of the branched initiator from 3.7 ppm (free) to 4.1 ppm (esterified).…”

Section: Polymer Chain Branching and The Use Of Initiators In Synthesismentioning

confidence: 99%

“…Among the synthetic biodegradable polymers, poly(lactic-co-glycolic acid) (PLGA) has generated great interest due to its excellent biocompatibility, biodegradability, non-toxicity, non-immunogenicity, and mechanical strength. As such, PLGA has been approved by the Food and Drug Administration (FDA), as well as the European Medicines Agency (EMA), for orthopedics fixation, medical surgical sutures, and parenteral sustained-release drug delivery systems (Biondi et al, 2008;Snejdrova et al, 2020). Since its discovery, PLGA has found varied applications in the field of medicine (Astete & Sabliov, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

Hua¹,

Su²,

Zhang³

et al. 2021

Drug Delivery

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Poly(lactic-co-glycolic acid) (PLGA) has garnered increasing attention as a candidate drug delivery polymer owing to its favorable properties, including its excellent biocompatibility, biodegradability, nontoxicity, non-immunogenicity, and mechanical strength. PLAG are specifically used as microspheres for the sustained/controlled and targeted delivery of hydrophilic or hydrophobic drugs, as well as biological therapeutic macromolecules, including peptide and protein drugs. PLGAs with different molecular weights, lactic acid (LA)/glycolic acid (GA) ratios, and end groups exhibit unique release characteristics, which is beneficial for obtaining diverse therapeutic effects. This review aims to analyze the composition of PLGA microspheres, and understand the manufacturing process involved in their production, from a quality by design perspective. Additionally, the key factors affecting PLGA microsphere development are explored as well as the principles involved in the synthesis and degradation of PLGA and its interaction with active drugs. Further, the effects elicited by microcosmic conditions on PLGA macroscopic properties, are analyzed. These conditions include variations in the organic phase (organic solvent, PLGA, and drug concentration), continuous phase (emulsifying ability), emulsifying stage (organic phase and continuous phase interaction, homogenization parameters), and solidification process (relationship between solvent volatilization rate and curing conditions). The challenges in achieving consistency between batches during manufacturing are addressed, and continuous production is discussed as a potential solution. Finally, potential critical quality attributes are introduced, which may facilitate the optimization of process parameters.

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Section: Polymer Chain Branching and The Use Of Initiators In Synthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

Hua¹,

Su²,

Zhang³

et al. 2021

Drug Delivery

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“…Therefore, we present PLGA nanospheres fabricated from several structural variants of PLGA with molecular weights ranging between 3500 Da and 14,000 as well as commercially available PLGA with molecular weight of 17,000 Da. The PLGA polymers varying in molar weight, lactic to glycolic acid ratio and molecular architecture used in the study have been previously described [20].…”

Section: Introductionmentioning

confidence: 99%

PLGA Based Nanospheres as a Potent Macrophage-Specific Drug Delivery System

et al. 2021

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Macrophages possess an innate ability to scavenge heterogenous objects from the systemic circulation and to regulate inflammatory diseases in various organs via cytokine production. That makes them attractive targets for nanomedicine-based therapeutic approaches to inflammatory diseases. In the present study, we have prepared several different poly(lactic-co-glycolic acid) (PLGA) polymer nanospheres for macrophage-targeted drug delivery using both nanoprecipitation and emulsification solvent evaporation methods. Two experimental linear PLGA polymers with relatively low molar weight, one experimental branched PLGA with unique star-like molecular architecture, and a commercially available PLGA, were used for nanosphere formulation and compared to their macrophage uptake capacity. The nanosphere formulations labelled with loaded fluorescent dye Rhodamine B were further tested in mouse bone marrow-derived macrophages and in hepatocyte cell lines AML-12, HepG2. We found that nanospheres larger than 100 nm prepared using nanoprecipitation significantly enhanced distribution of fluorescent dye selectively into macrophages. No effects of nanospheres on cellular viability were observed. Additionally, no significant proinflammatory effect after macrophage exposure to nanospheres was detected as assessed by a determination of proinflammatory cytokines Il-1β and Tnfα mRNA. All experimental PLGA nanoformulations surpassed the nanospheres obtained with the commercially available polymer taken as a control in their capacity as macrophage-specific carriers.

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“…These polymeric materials melt at 80 C and therefore can serve as efficient drug carrier systems. 37 Amphiphilic BCPs comprised of micellar mPEG block and coreforming PLA BCPs were studied by Li for controlled release of ATRA from the NPs. ATRA release occurs at faster rates with a lesser molecular weight of the copolymer and fewer drug contents.…”

Section: Biomedical Applications Of Bcpsmentioning

confidence: 99%

Recent developments in biodegradable block copolymers

Tekale

Rottenberg

Ingle

et al. 2021

Polymers for Advanced Techs

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Block copolymers consist of two or more segments of polymer chains in a typical arrangement through connected covalent bonds. Biodegradable block copolymers have emerged as useful carriers for controlled drug release, tissue engineering, and other biomedical applications due to their ability to form colloidal systems and tunable properties. This review focuses on recent advancements in the synthesis, characterization, and biomedical applications of biodegradable block copolymers.

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Branched PLGA derivatives with tailored drug delivery properties

Cited by 16 publications

References 26 publications

Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review

PLGA Based Nanospheres as a Potent Macrophage-Specific Drug Delivery System

Recent developments in biodegradable block copolymers

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