Branched Gold Nanoparticle Coating of <i>Clostridium novyi</i>‐NT Spores for CT‐Guided Intratumoral Injection

Park, Wooram; Cho, Soojeong; Huang, Xiaoke; Larson, Andrew C.; Kim, Dong‐Hyun

doi:10.1002/smll.201602722

Cited by 53 publications

(36 citation statements)

References 32 publications

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“…Limited bacteria related toxicity and limited tissue injury contributed to the effectiveness of this combination [ 130 ]. Branched gold nanoparticles coated with C. novyi NT were fabricated and used with computed image tomography for delivery in prostate cancer mouse models [ 131 ]. The nanoparticle coated spores delivered to the hypoxic region were effective in treating the central tumor regions due to localization of the anaerobic Clostridium spores however, normoxic peripheral cancer cells remained alive.…”

Section: Conventional Cancer Therapy In Combination With Bacteriotmentioning

confidence: 99%

Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Sawant

Patil

Gupta

et al. 2020

IJMS

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Conventional anti-cancer therapy involves the use of chemical chemotherapeutics and radiation and are often non-specific in action. The development of drug resistance and the inability of the drug to penetrate the tumor cells has been a major pitfall in current treatment. This has led to the investigation of alternative anti-tumor therapeutics possessing greater specificity and efficacy. There is a significant interest in exploring the use of microbes as potential anti-cancer medicines. The inherent tropism of the bacteria for hypoxic tumor environment and its ability to be genetically engineered as a vector for gene and drug therapy has led to the development of bacteria as a potential weapon against cancer. In this review, we will introduce bacterial anti-cancer therapy with an emphasis on the various mechanisms involved in tumor targeting and tumor suppression. The bacteriotherapy approaches in conjunction with the conventional cancer therapy can be effective in designing novel cancer therapies. We focus on the current progress achieved in bacterial cancer therapies that show potential in advancing existing cancer treatment options and help attain positive clinical outcomes with minimal systemic side-effects.

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Section: Conventional Cancer Therapy In Combination With Bacteriotmentioning

confidence: 99%

Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Sawant

Patil

Gupta

et al. 2020

IJMS

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“…Nanoparticles have several versatile features which pave their use in the fabrication of various imaging agents. For instance, ferric oxide nanoparticles [87,88] and gold nanoparticles [89] are widely used as contrast agents in MRI and CT scan, respectively. Consequently, such functional nanoparticles can be utilized in the development of injectable medicines for their local use in medical imaging.…”

Section: Localized Anticancer Immunotherapymentioning

confidence: 99%

Emerging Prospects for Nanoparticle-Enabled Cancer Immunotherapy

Buabeid

Arafa

Murtaza

2020

Journal of Immunology Research

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One of the standards for cancer treatment is cancer immunotherapy which treats both primary and metastasized tumors. Although cancer immunotherapeutics show better outcomes as compared with conventional approaches of cancer treatment, the currently used cancer immunotherapeutics have limited application in delivering cancer antigens to immune cells. Conversely, in solid tumors, tumor microenvironment suppresses the immune system leading to the evasion of anticancer immunity. Some promising attempts have been made to overcome these drawbacks by using different approaches, for instance, the use of biomaterial-based nanoparticles. Accordingly, various studies involving the application of nanoparticles in cancer immunotherapy have been discussed in this review article. This review not only describes the modes of cancer immunotherapy to reveal the importance of nanoparticles in this modality but also narrates nanoparticle-mediated delivery of cancer antigens and therapeutic supplements. Moreover, the impact of nanoparticles on the immunosuppressive behavior of tumor environment has been discussed. The last part of this review deals with cancer immunotherapy using a combination of traditional interventional oncology approach and image-guided local immunotherapy against cancer. According to recent studies, cancer therapy can potentially be improved through nanoparticle-based immunotherapy. In addition, drawbacks associated with the currently used cancer immunotherapeutics can be fixed by using nanoparticles.

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“…For example, iron oxide nanoparticles have been used in a variety of biomedical applications because they are synthesized from in vivo rich metals (i.e., iron) and can be used as MRI contrast agents [ 69 – 72 ]. Gold nanoparticles have high X-ray absorption and can be used as CT contrast agents [ 73 , 74 ]. Therefore, it should be possible to develop local injectable therapeutics suitable for use in medical imaging by adding such functional nanoparticles.…”

Section: Image-guided Local Cancer Immunotherapymentioning

confidence: 99%

New opportunities for nanoparticles in cancer immunotherapy

2018

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BackgroundRecently, cancer immunotherapy has become standard for cancer treatment. Immunotherapy not only treats primary tumors, but also prevents metastasis and recurrence, representing a major advantage over conventional cancer treatments. However, existing cancer immunotherapies have limited clinical benefits because cancer antigens are often not effectively delivered to immune cells. Furthermore, unlike lymphoma, solid tumors evade anti-cancer immunity by forming an immune-suppressive tumor microenvironment (TME). One approach for overcoming these limitations of cancer immunotherapy involves nanoparticles based on biomaterials.Main bodyHere, we review in detail recent trends in the use of nanoparticles in cancer immunotherapy. First, to illustrate the unmet needs for nanoparticles in this field, we describe the mechanisms underlying cancer immunotherapy. We then explain the role of nanoparticles in the delivery of cancer antigens and adjuvants. Next, we discuss how nanoparticles can be helpful within the immune-suppressive TME. Finally, we summarize current and future uses of nanoparticles with image-guided interventional techniques in cancer immunotherapy.ConclusionRecently developed approaches for using nanoparticles in cancer immunotherapy have enormous potential for improving cancer treatment. Cancer immunotherapy based on nanoparticles is anticipated not only to overcome the limitations of existing immunotherapy, but also to generate synergistic effects via cooperation between nanoparticles and immune cells.

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Branched Gold Nanoparticle Coating of Clostridium novyi‐NT Spores for CT‐Guided Intratumoral Injection

Cited by 53 publications

References 32 publications

Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment

Emerging Prospects for Nanoparticle-Enabled Cancer Immunotherapy

New opportunities for nanoparticles in cancer immunotherapy

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