Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems

Hobson, James J.; Edwards, Stephanie Ellen; Slater, Rebecca A.; Martin, Philip; Owen, Andrew; Rannard, Steve

doi:10.1039/c8ra01944d

Cited by 37 publications

(16 citation statements)

References 39 publications

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“…Using an epithelium monolayer transwell membrane the permeation of emulsion formulated HIV protease inhibitor Lopinavir was around 10 times higher than the aqueous application of the drug. 163 In a viral activity assay the antiviral effect (against HIV-1 IIIB) of drug-loaded nanoemulsions was similar to the aqueous based control. Additionally, it has been demonstrated that these highly branched polymers, synthesised by ATRP, can form stable nanoparticle composites with super-paramagnetic iron oxide nanoparticles (SPIONs) with future uses for delivery of drugs, imaging agents, or hyperthermia agents within cancer therapies.…”

Section: Divinyl Monomer Copolymerisationmentioning

confidence: 83%

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Cook

Perrier

2019

Adv Funct Materials

125

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Barriers to therapeutic transport in biological systems can prevent accumulation of drugs at the intended site, thus limiting the therapeutic effect against various diseases. Advances in synthetic chemistry techniques have recently increased the accessibility of complex polymer architectures for drug delivery systems, including branched polymer architectures. This article first outlines drug delivery concepts, and then defines and illustrates all forms of branched polymers including highly branched polymers, hyperbranched polymers, dendrimers, and branched–linear hybrid polymers. Many new types of branched and dendritic polymers continue to be reported; however, there is often confusion about how to accurately describe these complex polymer architectures, particularly in the interdisciplinary field of nanomedicine where not all researchers have in‐depth polymer chemistry backgrounds. In this context, the present review describes and compares different branched polymer architectures and their application in therapeutic delivery in a simple and easy‐to‐understand way, with the aim of appealing to a multidisciplinary audience.

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Section: Divinyl Monomer Copolymerisationmentioning

confidence: 83%

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Cook

Perrier

2019

Adv Funct Materials

125

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“…Various methods like low-energy emulsification method, phase inversion temperature method ultrasonication, high pressure homogenization, or microfluidization are used for their preparation [ 57 ]. Various oils like soyabean oil, castor oil, and peanut oil have been used as lipids [ 58 ]. NEs have advantages of increasing aqueous solubility, loading capacity, increased residence time in GIT, enhanced absorption and bioavailability, and lymphatic uptake [ 59 ].…”

Section: Nanotechnology Formulation Aspects and Their Application In mentioning

confidence: 99%

Nanotechnology-based antiviral therapeutics

Chakravarty

Vora

2020

Drug Deliv. and Transl. Res.

199

165

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The host immune system is highly compromised in case of viral infections and relapses are very common. The capacity of the virus to destroy the host cell by liberating its own DNA or RNA and replicating inside the host cell poses challenges in the development of antiviral therapeutics. In recent years, many new technologies have been explored for diagnosis, prevention, and treatment of viral infections. Nanotechnology has emerged as one of the most promising technologies on account of its ability to deal with viral diseases in an effective manner, addressing the limitations of traditional antiviral medicines. It has not only helped us to overcome problems related to solubility and toxicity of drugs, but also imparted unique properties to drugs, which in turn has increased their potency and selectivity toward viral cells against the host cells. The initial part of the paper focuses on some important proteins of influenza, Ebola, HIV, herpes, Zika, dengue, and corona virus and those of the host cells important for their entry and replication into the host cells. This is followed by different types of nanomaterials which have served as delivery vehicles for the antiviral drugs. It includes various lipid-based, polymer-based, lipid-polymer hybrid-based, carbon-based, inorganic metal-based, surface-modified, and stimuli-sensitive nanomaterials and their application in antiviral therapeutics. The authors also highlight newer promising treatment approaches like nanotraps, nanorobots, nanobubbles, nanofibers, nanodiamonds, nanovaccines, and mathematical modeling for the future. The paper has been updated with the recent developments in nanotechnology-based approaches in view of the ongoing pandemic of COVID-19.

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“…To the NEs, the lopinavir (Lpv) that inhibits the protease-mediated maturation of virions or efavirenz (Efz) that inhibits the viral RNA reverse transcription was loaded, and both the antiretroviral drug-loaded NEs exhibited enhanced permeability and antiviral activity against HIV-1 IIIB-infected MT4 cells. The apparent permeability of Lpv was almost an order of higher magnitude after 2 hours compared to the control aqueous-DMSO drug solution [ 76 ]. The self-nano emulsifying oil formulations (SNOFs) of Efz prepared with caproyl 90 and kolliphor EL showed a low percent dissolution efficiency and a high dissolution half-life less than 9 min for Efz under in vitro condition compared to free Efz [ 77 ].…”

Section: Essential Oil-based Nes/mes Antiviral and Drug Delivery Systmentioning

confidence: 99%

Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects

Franklyne

Gopinath

Mukherjee

et al. 2021

Current Opinion in Colloid & Interface Science

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Nanoemulsions (NEs) of essential oil (EO) have significant potential to target microorganisms, especially viruses. They act as a vehicle for delivering antiviral drugs and vaccines. Narrowing of drug discovery pipeline and the emergence of new viral diseases, especially, COVID-19 have created a niche to use nanoemulsions (NEs) for augmenting currently available therapeutic options. Published literature demonstrated that EOs have an inherent broad spectrum of activity across bacterial, fungal, and viral pathogens. The emulsification process significantly improved the efficacy of the active ingredients in the EOs. This article highlights the research findings and patent developments in the last two years especially, in EO antiviral activity, antiviral drug delivery, vaccine delivery, viral resistance development, and repurposing EO compounds against SARS-CoV2.

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Branched copolymer-stabilised nanoemulsions as new candidate oral drug delivery systems

Abstract: Branched copolymers offer very efficient nanoemulsion stabilisers with benefits for oral drug delivery.

Cited by 37 publications

References 39 publications

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Branched and Dendritic Polymer Architectures: Functional Nanomaterials for Therapeutic Delivery

Nanotechnology-based antiviral therapeutics

Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects

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