2020
DOI: 10.3390/nu12092875
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Branched-Chain Fatty Acids—An Underexplored Class of Dairy-Derived Fatty Acids

Abstract: Dairy fat and its fatty acids (FAs) have been shown to possess pro-health properties that can support health maintenance and disease prevention. In particular, branched-chain FAs (BCFAs), comprising approximately 2% of dairy fat, have recently been proposed as bioactive molecules contributing to the positive health effects associated with the consumption of full-fat dairy products. This narrative review evaluates human trials assessing the relationship between BCFAs and metabolic risk factors, while potential … Show more

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Cited by 112 publications
(108 citation statements)
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“…The only consistent exception were the branched chain fatty acids (BCFA), as their levels turned out to be significantly lower in kidney graft recipients. Branched chain fatty acids constitute a group derived mainly from ruminants (milk, dairy products, beef) [ 20 ]. Recent research, including our studies, suggests that BCFA promote weight maintenance and insulin sensitivity [ 21 , 22 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The only consistent exception were the branched chain fatty acids (BCFA), as their levels turned out to be significantly lower in kidney graft recipients. Branched chain fatty acids constitute a group derived mainly from ruminants (milk, dairy products, beef) [ 20 ]. Recent research, including our studies, suggests that BCFA promote weight maintenance and insulin sensitivity [ 21 , 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…Although endogenous production has also been confirmed, as BCFA were found to be synthesized from respective branched chain amino acids (BCAA), e.g., valine, leucine, isoleucine, the dietary intake of BCFA is presumably the major source of these FA in the body [ 20 ]. In the present study, we did not assess the diet of the patients, which is a limitation, underlined below.…”
Section: Discussionmentioning
confidence: 99%
“…These differences were suggestive of abnormal synthesis of the odd-chain FFAs in acne. Opposite to other bio uids, branched chain FA are relatively abundant in sebum 34 . Multiple sources contribute to their level, such as de novo synthesis by the SG, metabolism of skin microbes, and diet 35,36 .…”
Section: Discussionmentioning
confidence: 99%
“…Collectively, these dietary changes led to decreased energy intake due to decreased intake of all three macronutrients that were reflected in the decreased circulating levels of metabolites derived from these nutrients. Remarkably, many of these metabolites have been associated with the composition and intake of dairy products, including pentadecanoic acid [28,64], BCFA [65], lactose [28,29], and BCAA [66,67].…”
Section: Serum Metabolites Modification By Exclusion Of Dairy and Limitation Of Fermented Foodsmentioning
confidence: 99%