Brainstem Auditory Outcomes and Correlation With Neurodevelopment After Perinatal Asphyxia

Jiang, Ze D.; Liu, Xian Y.; Shi, Bin P.; Lin, Longshan; Bu, Cui F.; Wilkinson, A

doi:10.1016/j.pediatrneurol.2008.06.013

Cited by 23 publications

(20 citation statements)

References 22 publications

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“…11. Hypoxic-ischaemic encephalopathy [55–57], CNS damage [58, 59], epilepsy [60, 61], nephropathy [43], cardiomyopathy [62, 63], vascular pathologies [64], senescence [32, 65], diabetes mellitus [66, 67], cancer [68], neurodegenerative diseases [58], morbidity and mortality [69] and tissue remodelling [70] all belong to individual short- and long-term outcomes of birth asphyxia. Specialised issue of The EPMA Journal , further treat the major related topics, namely “PPPM in Diabetes”, “PPPM in Neurodegenerative Diseases”, “PPPM in Cancer”, “PPPM in Cardiovascular Diseases”, “PPPM in Body Culture and Sport Medicine”, “Healthcare Overview”, where the articles overview the innovative technologies of predictive diagnostics, targeted prevention measures and desirable personalisation of medical care [71–80].…”

Section: Central Biological Processes Affected By Perinatal Asphyxiamentioning

confidence: 99%

Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care

et al. 2011

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Perinatal Asphyxia—oxygen deficit at delivery—can lead to severe hypoxic ischaemic organ damage in newborns followed by a fatal outcome or severe life-long pathologies. The severe insults often cause neurodegenerative diseases, mental retardation and epilepsies. The mild insults lead to so-called “minimal brain-damage disorders” such as attention deficits and hyperactivity, but can also be associated with the development of schizophrenia and life-long functional psychotic syndromes. Asphyxia followed by re-oxygenation can potentially lead to development of several neurodegenerative pathologies, diabetes type 2 and cancer. The task of individual prediction, targeted prevention and personalised treatments before a manifestation of the life-long chronic pathologies usually developed by newborns with asphyxic deficits, should be given the extraordinary priority in neonatology and paediatrics. Socio-economical impacts of educational measures and advanced strategies in development of robust diagnostic approaches targeted at effected molecular pathways, biomarker-candidates and potential drug-targets for tailored treatments are reviewed in the paper.

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Section: Central Biological Processes Affected By Perinatal Asphyxiamentioning

confidence: 99%

Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care

et al. 2011

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“…However, the use of MR/ID has been replaced in England by the term learning disability (LD), which encompasses the full spectrum of developmental dysfunction or delay. In recent years, evidence for brain plasticity has accumulated [Johnston, ]. The extended age range of brain maturation has also been convincingly demonstrated [Shaw et al, 2008; Raznahan et al, ].…”

Section: Definitions and A Conceptual Frameworkmentioning

confidence: 99%

“…Early intervention has contributed positively to the developmental outcome of children with GDD [Guralnick, ]. A better understanding of brain plasticity [Johnston, ], on one hand, and the transactional processes between genetic and environmental factors, on the other hand [Sameroff and Fiese, ], provided a good rationale for anticipating developmental gains following intervention [Sharma ]. One may still argue that in the case of severe GDD/MR with and without neurological findings, the impact of environmental factors on the prognosis is relatively insignificant.…”

Section: Managementmentioning

confidence: 99%

Global Developmental Delay and Mental Retardation—A Pediatric Perspective

Tirosh¹,

Jaffe²

2011

Dev Disabil Res Revs

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Pediatricians play a leading role in the detection, diagnosis, and management of children with global developmental delay (GDD) and mental retardation (MR). Assessment, investigation, and consultation with the family are the prime responsibility of the developmental pediatrician, in collaboration with a multidisciplinary team. The model used by the developmental pediatrician depends on the community health framework. Significant progress has been recently achieved in identifying underlying etiologies, using a variety of laboratory tests including neuroimaging and genetic and metabolic investigations. Although being used to achieve an acceptable yield, this progress in diagnostic investigations should be associated with proper weighing of the value of each test to the diagnostic process. Optimal utilization of this rapidly expanding knowledge can only be accomplished in the setting of in-depth clinical evaluation, including a thoughtful assessment of the child and family needs. In this article, the literature on the process of clinical evaluation and laboratory work-up of the child with GDD/MR is reviewed, with an emphasis on a multidisciplinary team approach to the child and family needs. An integrated model used by the developmental pediatrician that relates to the process of evaluation and management as well as the consequences of the diagnosis on the child, his/her family, and the community is suggested.

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“…ABRs are the most sensitive and reliable methods used to evaluate such functional impairments (61,66). In particular, the two most widely used parameters are wave V latency and its I-V interval because they intimately reflect neuronal conduction, brainstem conduction time, myelination and synaptic function, both in the brainstem and in the central auditory pathway (31).…”

Section: Introductionmentioning

confidence: 99%

“…Thus, neural cells are particularly susceptible to energy failure (decreased ATP levels), cellular excitotoxicity and oxidative stress, which, in turn, can promote cell death (4,68) and in this sense, death receptor-activated pathways, altered mitochondrial function (50). HI events are also known to perturb neuron metabolism and depress synaptic function between cells (31). Although astrocytes can also be affected by HI, which can compromise their capacity for neurotransmitter uptake, they are more resistant to HI events than neurons (4,13).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

et al. 2015

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Maturation of the auditory pathway is dependent on the central nervous system myelination and it can be affected by pathologies such as neonatal hypoxic ischemic (HI) encephalopathy. Our aim was to evaluate the functional integrity of the auditory pathway and to visualize, by histological and cellular methods, the damage to the brainstem using a neonatal rat model of HI brain injury. To carry out this morphofunctional evaluation, we studied the effects of the administration of the antioxidants nicotine, melatonin, resveratrol and docosahexaenoic acid after hypoxia-ischemia on the inferior colliculus and the auditory pathway. We found that the integrity of the auditory pathway in the brainstem was altered as a consequence of the HI insult. Thus, the auditory brainstem response (ABR) showed increased I-V and III-V wave latencies. At a histological level, HI altered the morphology of the inferior colliculus neurons, astrocytes and oligodendricytes, and at a molecular level, the mitochondria membrane potential and integrity was altered during the first hours after the HI and reactive oxygen species (ROS) activity is increased 12 h after the injury in the brainstem. Following antioxidant treatment, ABR interpeak latency intervals were restored and the body and brain weight was recovered as well as the morphology of the inferior colliculus that was similar to the control group. Our results support the hypothesis that antioxidant treatments have a protective effect on the functional changes of the auditory pathway and on the morphological damage which occurs after HI insult.

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Brainstem Auditory Outcomes and Correlation With Neurodevelopment After Perinatal Asphyxia

Cited by 23 publications

References 22 publications

Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care

Birth asphyxia as the major complication in newborns: moving towards improved individual outcomes by prediction, targeted prevention and tailored medical care

Global Developmental Delay and Mental Retardation—A Pediatric Perspective

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

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