Brain-wide impacts of sedation on spontaneous activity and auditory processing in larval zebrafish
Itia A. Favre-Bulle,
Eli Muller,
Conrad Lee
et al.
Abstract:Despite their widespread use, we have limited knowledge of the mechanisms by which sedatives mediate their effects on brain-wide networks. This is, in part, due to the technical challenge of observing activity across large populations of neurons in normal and sedated brains. In this study, we examined the effects of the sedative dexmedetomidine, and its antagonist atipamezole, on spontaneous brain dynamics and auditory processing in zebrafish larvae. Our brain-wide, cellular-resolution calcium imaging reveals,… Show more
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