Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm

Reíter, Russel J.; Sharma, Ramaswamy; Cucielo, Maira Smaniotto; Tan, Dun Xian; Rosales-Corral, Sergio; Gancitano, Giuseppe; Chuffa, Luiz Gustavo de Almeida

doi:10.1007/s00018-023-04736-5

Cited by 17 publications

(10 citation statements)

References 226 publications

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“…The microvascular architecture of both tissues shares unique morphology with networks of the convoluted fenestrated capillary that distinctly facilitate CSF production [ 128 ]. Taken together, being responsible for melatonin synthesis and possibly CSF production may indicate a more prominent role of the pineal gland in moderating healthy glymphatic function than previously understood [ 129 ].…”

Section: Discussionmentioning

confidence: 99%

Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

et al. 2023

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Traumatic brain injury (TBI) is one of the most prevalent causes of morbidity in the United States and is associated with numerous chronic sequelae long after the point of injury. One of the most common long-term complaints in patients with TBI is sleep dysfunction. It is reported that alterations in melatonin follow TBI and may be linked with various sleep and circadian disorders directly (via cellular signaling) or indirectly (via free radicals and inflammatory signaling). Work over the past two decades has contributed to our understanding of the role of melatonin as a sleep regulator and neuroprotective anti-inflammatory agent. Although there is increasing interest in the treatment of insomnia following TBI, a lack of standardization and rigor in melatonin research has left behind a trail of non-generalizable data and ambiguous treatment recommendations. This narrative review describes the underlying biochemical properties of melatonin as they are relevant to TBI. We also discuss potential benefits and a path forward regarding the therapeutic management of TBI with melatonin treatment, including its role as a neuroprotectant, a somnogen, and a modulator of the circadian rhythm.

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Section: Discussionmentioning

confidence: 99%

Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

et al. 2023

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“…Sleep is an important physiological function to repair and clear tissue and brain [ 1 ]. World Health Organization expressed that 27% of the world’s population suffer from sleep disorders [ 2 , 3 ].…”

Section: Intruductionmentioning

confidence: 99%

Mediterranean diet adherence and sleep pattern: a systematic review of observational studies

fallah,

Aminianfar,

Esmaillzadeh

2024

BMC Nutr

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Background and aims Despite a huge body of evidence on the linkage between dietary intakes and pattern of sleeping, the findings are controversial. The current study aimed to summarize earlier findings on the association between adherence to Mediterranean diet (MD) and pattern of sleeping. Methods This study performed based on PRISMA guideline. Systematically search was applied in PubMed, Scopus and Google Scholar to find out relevant publications appeared up to February 2023. No restrictions on language and time of publication were applied. Duplicate citations were removed. We included observational studies which assessed MD as the main exposure and kind of sleep disorders as the main outcome. Results A total of 20 observational studies included. Out of these studies, two were cohort studies and 18 had a cross-sectional design. A total of 21,714 participants included. Usual dietary intakes were assessed using a validated Food Frequency Questionnaire, and a diet history questionnaire. Some studies did not report methods of measuring habitual dietary intakes. Adherence to MD was evaluated by KIDMED questionnaire, PREMED, alternate Mediterranean (aMed) questionnaire, MEDAS questionnaire, MedDietScore, MEDI-LITE score, modified Mediterranean Diet Score (mMDS), Mediterranean food pattern (MFP) and modified Mediterranean diet score (mMED). Pattern of sleeping was examined as sleep quality, sleep duration, sleep latency, sleep efficacy, sleepiness, sleep disturbance, taking a nap and some other sleep disorders. Conclusion In conclusion, findings of published studies highlighted the importance of consumption of MD for better sleep quality.

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“…The circadian clock coordinates the timing of several physiological processes including retinal function (Bhoi et al, 2022), cardiac metabolism (Luo et al, 2022;Schroder & Delisle, 2022), neural activity (Reiter et al, 2023), and myogenesis (Zhang et al, 2020).…”

Section: Circadian Regulation Of Cellular Processesmentioning

confidence: 99%

Circadian regulation in aging: Implications for spaceflight and life on earth

et al. 2023

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Alterations in the circadian system are characteristic of aging on Earth. With the decline in physiological processes due to aging, several health concerns including vision loss, cardiovascular disorders, cognitive impairments, and muscle mass loss arise in elderly populations. Similar health risks are reported as “red flag” risks among astronauts during and after a long‐term Space exploration journey. However, little is known about the common molecular alterations underlying terrestrial aging and space‐related aging in astronauts, and controversial conclusions have been recently reported. In light of the regulatory role of the circadian clock in the maintenance of human health, we review here the overlapping role of the circadian clock both on aging on Earth and spaceflight with a focus on the four most affected systems: visual, cardiovascular, central nervous, and musculoskeletal systems. In this review, we briefly introduce the regulatory role of the circadian clock in specific cellular processes followed by alterations in those processes due to aging. We next summarize the known molecular alterations associated with spaceflight, highlighting involved clock‐regulated genes in space flown Drosophila, nematodes, small mammals, and astronauts. Finally, we discuss common genes that are altered in terms of their expression due to aging on Earth and spaceflight. Altogether, the data elaborated in this review strengthen our hypothesis regarding the timely need to include circadian dysregulation as an emerging hallmark of aging on Earth and beyond.

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Brain washing and neural health: role of age, sleep, and the cerebrospinal fluid melatonin rhythm

Cited by 17 publications

References 226 publications

Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

Traumatic Brain Injury, Sleep, and Melatonin—Intrinsic Changes with Therapeutic Potential

Mediterranean diet adherence and sleep pattern: a systematic review of observational studies

Circadian regulation in aging: Implications for spaceflight and life on earth

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