Brain volumetric changes in the general population following the COVID-19 outbreak and lockdown

Salomon, Tom; Cohen, Akiba A.; Barazany, Daniel; Ben-Zvi, Gal; Botvinik‐Nezer, Rotem; Gera, Rani; Oren, Shiran; Roll, Dana; Rozic, Gal; Saliy, Anastasia; Tik, Niv; Tsarfati, Galia; Tavor, Ido; Schönberg, Tom; Assaf, Yaniv

doi:10.1016/j.neuroimage.2021.118311

Cited by 35 publications

(21 citation statements)

References 35 publications

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“…This is reflected in the reported results of the whole-brain analyses that demonstrated effects in regions that are not directly involved in emotional processing. However, our whole-brain findings still largely overlap with the regional profile reported by Salomon et al 14 demonstrating (besides previously mentioned amygdalar changes) volumetric increases in putamen and the anterior temporal cortex, which the authors linked to the intense experience associated with the COVID19 pandemic.…”

Section: Discussionsupporting

confidence: 85%

“…One study has demonstrated how a single extreme aversive global event may impact fear circuits by linking individuals’ geographical proximity to the site of 9/11 terrorist attacks to the reactivation of the amygdala during memory recollection 13 . In line with this, a recent study has suggested that intense experience of the COVID19 outbreak is linked to volumetric increase of the amygdala 14 .…”

Section: Introductionmentioning

confidence: 60%

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Large-scale societal dynamics are reflected in human mood and brain

Lebedev

Abé

Acar

et al. 2022

Sci Rep

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The stock market is a bellwether of socio-economic changes that may directly affect individual well-being. Using large-scale UK-biobank data generated over 14 years, we applied specification curve analysis to rigorously identify significant associations between the local stock market index (FTSE100) and 479,791 UK residents’ mood, as well as their alcohol intake and blood pressure adjusting the results for a large number of potential confounders, including age, sex, linear and non-linear effects of time, research site, other stock market indexes. Furthermore, we found similar associations between FTSE100 and volumetric measures of affective brain regions in a subsample (n = 39,755; measurements performed over 5.5 years), which were particularly strong around phase transitions characterized by maximum volatility in the market. The main findings did not depend on applied effect-size estimation criteria (linear methods or mutual information criterion) and were replicated in two independent US-based studies (Parkinson’s Progression Markers Initiative; n = 424; performed over 2.5 years and MyConnectome; n = 1; 81 measurements over 1.5 years). Our results suggest that phase transitions in the society, indexed by stock market, exhibit close relationships with human mood, health and the affective brain from an individual to population level.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 60%

Large-scale societal dynamics are reflected in human mood and brain

Lebedev

Abé

Acar

et al. 2022

Sci Rep

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“…Lastly, there is evidence to suggest that to exposure COVID-19 itself and/or the stress of COVID-19 may alter brain structures associated with mental health ( Valenzano et al, 2020 ). For example, one study found volumetric increases in brain regions commonly linked to internalizing disorders, in relation to a COVID-19-related lockdown ( Salomon et al, 2021 ). Future research can build on the findings reported in this study by examining neurobiological mechanisms accounting for the relation between the COVID-19 pandemic and mental health.…”

Section: Discussionmentioning

confidence: 99%

The acute and persisting impact of COVID-19 on trajectories of adolescent depression: Sex differences and social connectedness

Liu¹,

Davis²,

Palma³

et al. 2022

Journal of Affective Disorders

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“…To identify the variables of interest: (i) the emotion regulation strategy explaining the highest degree of variation in anxiety or depression for W2 and W3 was selected; (ii) a priori defined structural brain measures explaining the highest degree of emotion regulation strategy use at W2 were selected. According to the hypothesized mediation framework ( Figure 2 ), it is assumed that brain structure may be altered, as suggested by reports observing volumetric changes in healthy participants in anxiety- and stress-related brain regions following COVID-19 onset ( Salomon et al. , 2021 ).…”

Section: Methodsmentioning

confidence: 99%

Prefrontal cortical thickness, emotion regulation strategy use and COVID-19 mental health

Dimanova

Borbás

Schnider

et al. 2022

Social Cognitive and Affective Neuroscience

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Covid-19 and associated restrictions have been linked to negative mental health outcomes across the globe. Cognitive emotion regulation strategies, neurally supported by prefrontal and limbic regions, constitute means to mitigate negative affects resulting from adverse life experiences. Variations in cognitive emotion regulation strategy use, anxiety and depression were assessed in 43 adults (31♀/12♂, age=35.14±9.20y) during the first months following Covid-19 onset and at the end of 2020 (seven assessments). Direct and indirect effects of emotion regulatory brain structures assessed prior to the pandemic and emotion regulation strategy use during the pandemic were assessed in relation to mental well-being. Varying levels of anxiety and depression were observed. While adaptive emotion regulation strategies were most frequently employed, maladaptive strategies explained the highest variation in anxiety and depression scores. The effectiveness of specific emotion regulation strategies varied. Momentary emotion regulation strategy use mediated the association between cortical thickness in right lateral prefrontal cortex assessed prior to the pandemic and mental health during the pandemic. Early mental health measures impacted later mental well-being. Maladaptive strategies have a negative effect on mental health during prolonged stress as induced by pandemics, providing possible targets for intervention.

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Brain volumetric changes in the general population following the COVID-19 outbreak and lockdown

Cited by 35 publications

References 35 publications

Large-scale societal dynamics are reflected in human mood and brain

Large-scale societal dynamics are reflected in human mood and brain

The acute and persisting impact of COVID-19 on trajectories of adolescent depression: Sex differences and social connectedness

Prefrontal cortical thickness, emotion regulation strategy use and COVID-19 mental health

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