Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study

Haren, Neeltje E.M. van; Cahn, Wiepke; Pol, Hilleke E. Hulshoff; Schnack, Hugo G.; Caspers, Esther; Lemstra, A.; Sitskoorn, Margriet M.; Wiersma, Durk; Bosch, R. J. Van Den; Dingemans, Peter; Schene, Aart H.; Kahn, René S.

doi:10.1016/s0920-9964(03)00018-5

Cited by 82 publications

(57 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in agreement with a large multicentre first episode schizophrenia study with a 2 year follow up period (Van Haren et al, 2003). Cahn et al (2006), and more recently, Lappin et al (2013) found that longitudinal changes in brain volume predicted GAF scores after 5 and 6 year follow up respectively.…”

Section: Clinical Correlates and Predictorssupporting

confidence: 88%

Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome

Scanlon

Anderson‐Schmidt

Kilmartin

et al. 2014

Schizophrenia Research

View full text Add to dashboard Cite

First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study we adopt complementary methods of assessing the structural integrity of grey matter in FEP patients and assess whether these relate to patient clinical and functional outcome at 3 year follow-up. 1.5 Tesla T1-weighted Magnetic Resonance (MR) images were acquired for 46 patients experiencing their first episode of psychosis and 46 healthy controls. Cerebral cortical thickness and local gyrification index (LGI) were investigated using FreeSurfer software. Volume and shape of the hippocampus, caudate and lateral ventricles were assessed using manual tracing and spherical harmonics applied for shape description. A cluster of cortical thinning was identified in FEP compared to controls; this was located in the right superior temporal gyrus, sulcus, extended into the middle temporal gyrus (lateral temporal cortex -LTC). Bilateral caudate volumes were significantly lower in FEP relative to controls and the right caudate also displayed regions of shape deflation in the FEP group. No significant structural abnormalities were identified in cortical LGI or hippocampal or lateral ventricle volume/shape. Neither LTC nor caudate abnormalities were related to change in symptom severity or global functioning 3 years later. LTC and caudate abnormalities are present at the first episode of psychosis but do not appear to directly affect clinical or functional outcome.

show abstract

Section: Clinical Correlates and Predictorssupporting

confidence: 88%

Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome

Scanlon

Anderson‐Schmidt

Kilmartin

et al. 2014

Schizophrenia Research

View full text Add to dashboard Cite

show abstract

“…Because schizophrenia may be associated with volume reductions in certain brain regions (Selemon et al, 2002;Selemon and Goldman-Rakic, 1999;van Haren et al, 2003), such as the superior temporal gyrus, the medial temporal lobe, and prefrontal cortex (Shenton et al, 2001), MRS data are usually normalized for tissue volume (Ohrmann et al, 2006). Nonetheless, it is difficult to completely separate the issues of tissue volume and metabolite concentrations as measured by MRI and MRS, and some differences observed between schizophrenic patients and controls may have a volume component.…”

Section: Magnetic Resonance Spectroscopy and Imaging Of Naamentioning

confidence: 99%

N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology

Moffett

Ross

Arun

et al. 2007

Progress in Neurobiology

1,208

1,126

View full text Add to dashboard Cite

The brain is unique among organs in many respects, including its mechanisms of lipid synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate (NAA), which is synthesized from aspartate and acetyl-coenzyme A in neurons, appears to be a key link in these distinct biochemical features of CNS metabolism. During early postnatal CNS development, the expression of lipogenic enzymes in oligodendrocytes, including the NAA-degrading enzyme aspartoacylase (ASPA), is increased along with increased NAA production in neurons. NAA is transported from neurons to the cytoplasm of oligodendrocytes, where ASPA cleaves the acetate moiety for use in fatty acid and steroid synthesis. The fatty acids and steroids produced then go on to be used as building blocks for myelin lipid synthesis. Mutations in the gene for ASPA result in the fatal leukodystrophy Canavan disease, for which there is currently no effective treatment. Once postnatal myelination is completed, NAA may continue to be involved in myelin lipid turnover in adults, but it also appears to adopt other roles, including a bioenergetic role in neuronal mitochondria. NAA and ATP metabolism appear to be linked indirectly, whereby acetylation of aspartate may facilitate its removal from neuronal mitochondria, thus favoring conversion of glutamate to alpha ketoglutarate which can enter the tricarboxylic acid cycle for energy production. In its role as a mechanism for enhancing mitochondrial energy production from glutamate, NAA is in a key position to act as a magnetic resonance spectroscopy marker for neuronal health, viability and number. Evidence suggests that NAA is a direct precursor for the enzymatic synthesis of the neuron specific dipeptide N-acetylaspartylglutamate, the most concentrated neuropeptide in the human brain. Other proposed roles for NAA include neuronal osmoregulation and axon-glial signaling. We propose that NAA may also be involved in brain nitrogen balance. Further research will be required to more fully understand the biochemical functions served by NAA in CNS development and activity, and additional functions are likely to be discovered.

show abstract

“…DeLisi et al 1997 ;McCarley et al 1999 ;Rapoport et al 1999 ;Lieberman et al 2001 ;Ho et al 2003 ;van Haren et al 2003 ;Theberge et al 2007). Lieberman et al (2005) documented global gray matter reductions early in schizophrenia.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

The psychoses: Cluster 3 of the proposed meta-structure for DSM-V and ICD-11

et al. 2009

View full text Add to dashboard Cite

Carpenter, W. T. Jr.; Bustillo, J. R.; Thaker, G. K.; van Os, J.; Krueger, R. F.; and Green, M. J., ,"The psychoses: Cluster 3 of the proposed meta-structure for DSM-V and ICD-11." Psychological Medicine.39,12. 2025-2042 The psychoses: Cluster 3 of the proposed meta-structure for DSM-V and ICD-11 Background. In an effort to group mental disorders on the basis of etiology, five clusters have been proposed. Here we consider the validity of the cluster comprising selected psychotic and related disorders.Method. A group of diagnostic entities classified under schizophrenia and other psychotic disorders in DSM-IV-TR were assigned to this cluster and the bordering disorders, bipolar (BD) and schizotypal personality disorders (SPD), were included. We then reviewed the literature in relation to 11 validating criteria proposed by the DSM-V Task Force Study Group.Results. Relevant comparisons on the 11 spectrum criteria are rare for the included disorders except for schizophrenia and the two border conditions, BD and SPD. The core psychosis group is congruent at the level of shared psychotic psychopathology and response to antipsychotic medication. BD and SPD are exceptions in that psychosis is not typical in BD-II disorder and frank psychosis is excluded in SPD. There is modest similarity between schizophrenia and BD relating to risk factors, neural substrates, cognition and endophenotypes, but key differences are noted. There is greater support for a spectrum relationship of SPD and schizophrenia. Antecedent temperament, an important validator for other groupings, has received little empirical study in the various psychotic disorders.Conclusions. The DSM-IV-TR grouping of psychotic disorders is supported by tradition and shared psychopathology, but few data exist across these diagnoses relating to the 11 spectrum criteria. The case for including BD is modest, and the relationship of BD to other mood disorders is addressed elsewhere. Evidence is stronger for inclusion of SPD, but the relationship with other personality disorders along the 11 criteria is not addressed and the absence of psychosis presents a conceptual problem. There are no data along the 11 spectrum criteria that are decisive for a cluster based on etiology, and inclusion of BD and SPD is questionable.

show abstract

Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study

Cited by 82 publications

References 40 publications

Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome

Cortical thinning and caudate abnormalities in first episode psychosis and their association with clinical outcome

N-Acetylaspartate in the CNS: From neurodiagnostics to neurobiology

The psychoses: Cluster 3 of the proposed meta-structure for DSM-V and ICD-11

Contact Info

Product

Resources

About