Brain vital signs detect concussion-related neurophysiological impairments in ice hockey

Fickling, Shaun D.; Smith, Aynsley M.; Pawlowski, Gabriela; Hajra, Sujoy Ghosh; Liu, Careesa C.; Farrell, Kyle; Jorgensen, Janelle; Song, Xiaowei; Stuart, Michael J.; D’Arcy, Ryan C.N.

doi:10.1093/brain/awy317

Cited by 38 publications

(67 citation statements)

References 29 publications

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“…These changes can create different profiles for different conditions. For example, prior research in brain vital signs has demonstrated different profiles for concussed and non-concussed athletes (Fickling et al, 2019 ).…”

Section: Clinical Timeline and Methodsmentioning

confidence: 99%

“…The brain vital signs framework (Ghosh Hajra et al, 2016 , 2018a ; Fickling et al, 2019 ) provides a rapid evaluation of evoked brain responses through quantified EEG, extracted as event-related potentials (ERPs). ERPs provide an objective, physiological measure of cognitive function (Gawryluk and D’Arcy, 2010 ; Luck, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…Response amplitude (microvolts) and latency (milliseconds) measures can be extracted for each of the three ERPs for a total of six measures (Ghosh Hajra et al, 2016 ). These measures can also be converted into standardized brain scores for intuitive interpretation within a radar plot format to visualize an overall cognitive function and subsequent change over time (Fickling et al, 2019 ). The brain’s vital signs framework has been successfully shown to be sensitive to cognitive changes in both healthy aging and brain injury (Ghosh Hajra et al, 2016 ; Fickling et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report

Fickling

Greene²,

Greene³

et al. 2020

Front. Hum. Neurosci.

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Using a longitudinal case study design, we have tracked the recovery of motor function following severe traumatic brain injury (TBI) through a multimodal neuroimaging approach. In 2006, Canadian Soldier Captain (retired) Trevor Greene (TG) was attacked with an axe to the head while on tour in Afghanistan. TG continues intensive daily rehabilitation, which recently included the integration of physical therapy (PT) with neuromodulation using translingual neurostimulation (TLNS) to facilitate neuroplasticity. Recent findings with PT + TLNS demonstrated that recovery of motor function occurred beyond conventional time limits, currently extending past 14-years post-injury. To investigate whether PT + TLNS similarly resulted in associated cognitive function improvements, we examined event-related potentials (ERPs) with the brain vital signs framework. In parallel with motor function improvements, brain vital signs detected significant increases in basic attention (as measured by P300 response amplitude) and cognitive processing (as measured by contextual N400 response amplitude). These objective cognitive improvements corresponded with TG’s self-reported improvements, including a noteworthy and consistent reduction in ongoing symptoms of post-traumatic stress disorder (PTSD). The findings provide valuable insight into the potential importance of non-invasive neuromodulation in cognitive rehabilitation, in addition to initial indications for physical rehabilitation.

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Section: Clinical Timeline and Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report

Fickling

Greene²,

Greene³

et al. 2020

Front. Hum. Neurosci.

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show abstract

“…However, conventional ERP methodology and subsequent analyses are typically complex and time-consuming. To translate this laboratory capability into clinical applications, our group developed and validated a rapid evaluation platform known as the “brain vital signs” framework (Ghosh et al, 2016 , 2018 ; Fickling et al, 2019 ). The brain vital signs framework employs a portable, low-density EEG system with automated, user-friendly software that facilitates the quick assessment of several key ERPs serving as brain function indicators.…”

Section: Introductionmentioning

confidence: 99%

“…Together, the N100, P300, and N400 measurements of brain function provide enhanced sensitivity to track cognitive changes in the brain. The brain’s vital signs framework has been successfully shown to be sensitive to cognitive changes in both healthy aging and brain injury (Ghosh et al, 2016 ; Fickling et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Brain Vital Signs Detect Information Processing Differences When Neuromodulation Is Used During Cognitive Skills Training

Smith¹,

Livingstone²,

Fickling³

et al. 2020

Front. Hum. Neurosci.

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Background: Neuromodulation through translingual neurostimulation (TLNS) has been shown to initiate long-lasting processes of neuronal reorganization with a variety of outcomes (i.e., neuroplasticity). Non-invasive TLNS is increasingly accessible through the Portable Neuromodulation Stimulator (PoNS), a medical device that delivers electrical stimulation to the tongue to activate the trigeminal (V) and facial (VII) cranial nerves. Anecdotal reports from previous clinical studies have suggested incidental improvements in cognitive function. To objectively explore this observation, we examined TLNS-related effects on the semantic N400 brain vital sign cognitive response during cognitive skills training in healthy individuals. Methods: Thirty-seven healthy volunteers were randomized to receive simultaneous TLNS (treatment) or no TLNS (control) while undergoing cognitive skills training. Cognitive training was conducted for two 20-min sessions (morning and afternoon/evening) over 3 consecutive days. Brain vital signs were evaluated at baseline, Day 1, and Day 3. Analyses focused on cognitive processing as measured by N400 changes in amplitude and latency. Results: Over the 3-day course of cognitive training, the N400 amplitude decreased significantly in the control group due to habituation (p = 0.028). In contrast, there was no significant change in the TLNS treatment group. Conclusion: TLNS led to a sustained N400 response during cognitive skills training, as measured by the brain's vital signs framework. The study findings suggest differential learning effects due to neuromodulation, consistent with increased attention and cognitive vigilance.

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Revisit the formation of destination brand personality

Wang

Liu

et al. 2022

Annals of Tourism Research

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Brain vital signs detect concussion-related neurophysiological impairments in ice hockey

Cited by 38 publications

References 29 publications

Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report

Brain Vital Signs Detect Cognitive Improvements During Combined Physical Therapy and Neuromodulation in Rehabilitation From Severe Traumatic Brain Injury: A Case Report

Brain Vital Signs Detect Information Processing Differences When Neuromodulation Is Used During Cognitive Skills Training

Revisit the formation of destination brand personality

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