Brain Viability and Function Analyzer: Multiparametric Real-Time Monitoring in Neurosurgical Patients

Mayevsky, Avraham; Doron, Amihood; Meilin, Sigal; Manor, Tamar; Ornstein, Eugene; Ouaknine, G

doi:10.1007/978-3-7091-6415-0_13

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…This type of calibration is not absolute, but it provides reliable and reproducible results for different animals and different laboratories [12,20]. The combination of NADH fluorescence and LDF techniques has been routinely utilized in our laboratory for the past 20 years [25][26][27][28].…”

Section: Mitochondrial Nadh (A)mentioning

confidence: 99%

Perioperative Cardiovascular Evaluation of Patients Oxygen Balance and Tissue Metabolic Score (TMS)

Mayevsky¹,

Tolmasov²,

Mandelbaum³

2018

AJCTS

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During the perioperative period of cardiovascular surgeries an imbalance between oxygen supply and demand may lead to postoperative cognitive decline that may affect about 20% of the operated patients. In order to minimize the development of brain damage, few companies had developed monitoring devices that could provide real-time information regarding brain oxygenation, brain electrical activities or cerebral blood flow. Nevertheless this approach is not the appropriate way to detect an early warning signal that may serve as an indicator of brain negative oxygen balance. The alternative approach is to monitor tissue oxygen balance of one of the less vital organ in the body that may serve as an early warning signal of deterioration of body oxygen balance. In this review, the use of a multiparametric monitoring device (CritiView) connected to the patient's urethral wall via a 3-way Foley catheter that measure in real time 4 parameters representing tissue oxygen balance. Mitochondrial NADH is measured by surface fluorometry/reflectometry. In addition, tissue microcirculatory blood flow, tissue reflectance and hemoglobin oxygenation are measured as well. The measured 4 parameters could be integrated together with systemic hemodynamic parameters to provide in real time a new Tissue Metabolic Score (TMS). The device was tested both in vitro and in vivo in a small animal model and in preliminary clinical trials in patients undergoing vascular or open heart surgery. In patients, the monitoring started immediately after the insertion of a 3-way Foley catheter (urine collection) to the patient and was stopped when the patient was discharged from the operation room. The results show that monitoring the Urethral wall oxygen balance provides information in correlation to the surgical procedure performed.

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Section: Mitochondrial Nadh (A)mentioning

confidence: 99%

Perioperative Cardiovascular Evaluation of Patients Oxygen Balance and Tissue Metabolic Score (TMS)

Mayevsky¹,

Tolmasov²,

Mandelbaum³

2018

AJCTS

View full text Add to dashboard Cite

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Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: II: human studies

Mayevsky

Barbiro-Michaely

2012

J Clin Monit Comput

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Monitoring the mitochondrial function, alone or together with microcirculatory blood flow, volume and hemoglobin oxygenation in patients, is very rare. The integrity of microcirculation and mitochondrial activity is a key factor in keeping normal cellular activities. Many pathological conditions in patients are directly or indirectly related to dysfunction of the mitochondria. Evaluation of mitochondrial activity by measuring the autofluorescence of NADH has been the most practical approach since the 1950s. This review, which accompanies part I, presents the principles and technological aspects of various devices used in order to monitor mitochondrial NADH redox state and tissue viability in patients. In part I, the detailed technological aspects of NADH monitoring were described. Typical results accumulated in our studies since the mid-1990s are presented as well. We were able to apply the fiber optic based NADH fluorometry to several organs monitored in vivo in patients under various pathophysiological conditions.

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Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: I. Basic methodology and animal studies

Mayevsky

Barbiro-Michaely

2012

J Clin Monit Comput

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Normal mitochondrial function in the process of metabolic energy production is a key factor in maintaining cellular activities. Many pathological conditions in animals, as well as in patients, are directly or indirectly related to dysfunction of the mitochondria. Monitoring the mitochondrial activity by measuring the autofluorescence of NADH has been the most practical approach since the 1950s. This review presents the principles and technological aspects, as well as typical results, accumulated in our laboratory since the early 1970s. We were able to apply the fiber-optic-based NADH fluorometry to many organs monitored in vivo under various pathophysiological conditions in animals. These studies were the basis for the development of clinical monitoring devices as presented in accompanying article. The encouraging experimental results in animals stimulated us to apply the same technology in patients after technological adaptations as described in the accompanying article. Our medical device was approved for clinical use by the FDA.

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Brain Viability and Function Analyzer: Multiparametric Real-Time Monitoring in Neurosurgical Patients

Cited by 5 publications

References 11 publications

Perioperative Cardiovascular Evaluation of Patients Oxygen Balance and Tissue Metabolic Score (TMS)

Perioperative Cardiovascular Evaluation of Patients Oxygen Balance and Tissue Metabolic Score (TMS)

Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: II: human studies

Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: I. Basic methodology and animal studies

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