Brain tumour-associated status epilepticus

Status epilepticus secondary to glioma

“…LGG allows for development of functional changes whereas the rapid growth in HGG leads to distortion of cortical tissue and edema [24,25]. Even though single or recurrent seizures are more common in LGG, the risk of tumor associated SE appears to be directly proportional to tumor grade [26]. HGG is fivefold as common as LGG in Europe [27] but as epilepsy was the major inclusion criterion, LGG constitutes as many as half of the patients in our database.…”

Etiological assessment of status epilepticus

“…Besides, knowledge about SE and tumors has been confounded by several biases: the retrospective nature of most studies, small sample size, differences in tumor grade and histological tumor types across studies, epidemiological factors (especially age) and heterogeneous definitions of SE. Despite the consensus about the supratentorial location of brain tumors, the influence of the lobar location triggering SE remains equivocal: 77% were located in the temporal lobe in one cohort [93], whereas they were mostly frontal in other publications [92]. Information is too scarce to specify if an AED tailored to histological type would improve its management.…”

“…Unlike seizures unrelated to SEs and associated with brain tumors, SE risk is higher later in the course of the tumor progression and is directly proportional to the tumor grade (especially high-grade gliomas) [92]. It is preferentially linked to tumor changes: mostly progression [93], edema or hemorrhage.…”

Seizures in patients with cancer

“…75,76 Patients who have brain tumors can develop status epilepticus, which is considered a neurologic emergency. 77 The initial management is outlined in Figure 2. Status epilepticus can be either convulsive or nonconvulsive.…”