Abstract:-Stereotactic radiotherapy of solitary, mainly spherical metastases in the brain is often superior to other known methods with respect to palliation and survival. The number of patients is, however, relatively small.
“…Furthermore, during the 1980s, a marked change in approach to the morphological verification of even advanced intracranial processes occurred. Although therapy for intracranial tumours, mainly malignant gliomas, has not changed markedly, better diagnostics with fewer misclassifications may have influenced prognosis in a positive direction (49,50). A clear shift upwards in the RSR curves is seen between the mid-1970s and mid-1980s for both males and females (Fig.…”
“…Furthermore, during the 1980s, a marked change in approach to the morphological verification of even advanced intracranial processes occurred. Although therapy for intracranial tumours, mainly malignant gliomas, has not changed markedly, better diagnostics with fewer misclassifications may have influenced prognosis in a positive direction (49,50). A clear shift upwards in the RSR curves is seen between the mid-1970s and mid-1980s for both males and females (Fig.…”
“…16 Considerable research has been conducted on optimal radiation doses, and results suggest that a dose of 6000 cGy increases survival over a dose of 4500 cGy. 5,17 Additional research is evaluating other methods of timing and targeting radiation.…”
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HTAThe effectiveness and cost-effectiveness of temozolomide for the treatment of recurrent malignant glioma: a rapid and systematic review This report should be referenced as follows:Dinnes J, Cave C, Huang S, Major K, Milne R.The effectiveness and cost-effectiveness of temozolomide for the treatment of recurrent malignant glioma: a rapid and systematic review. 2001;5(13).
Health Technol Assess
Health Technology Assessment is indexed in Index Medicus/MEDLINE and Excerpta Medica/EMBASE.Copies of the Executive Summaries are available from the NCCHTA website (see opposite).
NHS R&D HTA ProgrammeT he NHS R&D Health Technology Assessment (HTA) Programme was set up in 1993 to ensure that high-quality research information on the costs, effectiveness and broader impact of health technologies is produced in the most efficient way for those who use, manage and provide care in the NHS.The research reported in this monograph was commissioned by the HTA Programme on behalf of the National Institute for Clinical Excellence (NICE). Rapid reviews are completed in a limited time to inform the appraisal and guideline development processes managed by NICE. The review brings together evidence on key aspects of the use of the tec...
“…For CF external beam RT at a total dose of 60 Gy the tumor progression-free interval is short, mainly in patients having glioblastoma histology and:or other poor prognostic factors (1,2). The introduction of image-based conformal methods actually encourages clinicians to be more accurate in dose placement and in acquisition of detailed dose distributions, with an option of dose escalation.…”
Section: Discussionmentioning
confidence: 99%
“…External beam radiotherapy (RT) is considered to be the routine treatment for malignant gliomas, but the results with this method are disappointing (1,2). Efforts have been made to escalate dose in order to improve local control (3,4).…”
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