Brain tumors: L-[1-C-11]tyrosine PET for visualization and quantification of protein synthesis rate.

Pruim, Jan; Willemsen, Atm; Molenaar, Willemina M.; Waarde, Aren van; Paans, Amj; Heesters, Maam; Kito, Go; Visser, Gerben M.; Franssen, Ejf; Vaalburg, W

doi:10.1148/radiology.197.1.7568827

Cited by 64 publications

(20 citation statements)

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“…MET and 11 C-tyrosine have been shown to significantly accumulate in a variety of extracranial malignant tumors including lung cancer, head and neck cancers, breast cancer, sarcomas, and malignant lymphomas (206)(207)(208)(209)(210)(211)(212). All these tumors could be visualized with high contrast.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Tumor Cell Metabolism Imaging

Plathow¹,

Weber²

2008

J Nucl Med

276

221

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Molecular imaging of tumor metabolism has gained considerable interest, since preclinical studies have indicated a close relationship between the activation of various oncogenes and alterations of cellular metabolism. Furthermore, several clinical trials have shown that metabolic imaging can significantly impact patient management by improving tumor staging, restaging, radiation treatment planning, and monitoring of tumor response to therapy. In this review, we summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism.

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Section: Clinical Applicationsmentioning

confidence: 99%

Tumor Cell Metabolism Imaging

Plathow¹,

Weber²

2008

J Nucl Med

276

221

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“…However, the rate of amino acid transport rather than the rate of protein synthesis appears to be the major determinant of in vivo uptake of radiolabeled amino acids used in tumor imaging studies [54][55][56]. The natural amino acids L-[ 11 C]leucine and L-[ 11 C]tyrosine have been used to measure protein synthesis rates in vivo using kinetic modeling [57][58][59][60]. Thus far, there is no clear evidence that estimation of protein synthesis with radiolabeled amino acids provides additional clinical information in tumor imaging as compared to transport rates.…”

Section: Amino Acid Transportmentioning

confidence: 99%

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

McConathy

Goodman

2008

Cancer Metastasis Rev

108

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Amino acids are required nutrients for proliferating tumor cells, and amino acid transport is upregulated in many tumor types. Studies of radiolabeled amino acids in animals and humans demonstrate that amino acid based tracers have advantageous characteristics relative to 2-[(18)F]fluoro-2-deoxyglucose in certain tumors, particularly brain gliomas. Non-natural amino acids for tumor imaging generally have greater metabolic stability and can be labeled with longer-lived radionuclides for positron emission tomography and single photon emission computed tomography such as fluorine-18 and iodine-123. Amino acids enter cells via amino acid transport with varying selectivity based on their chemical structure. This review focuses on the rationale, biological basis, current status and future prospects of radiolabeled non-natural amino acids for tumor imaging and discusses various classes of these compounds including aromatic, alicyclic and alpha,alpha-dialkyl amino acids.

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“…Pruim et al [30], using 18 F-tyrosine PET imaging for both primary and recurrent brain tumors (including metastases and cerebral lymphomas), find 91% of 22 tumors positive for uptake. Wienhard et al [31] could demonstrate increased uptake and transport rates of 18 F-tyrosine in primary brain tumors (n=15).…”

Section: Brain Tumor Detectionmentioning

confidence: 99%

Molecular Imaging of Brain Tumors: A Bridge Between Clinical and Molecular Medicine?

2007

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As the research on cellular changes has shed invaluable light on the pathophysiology and biochemistry of brain tumors, clinical and experimental use of molecular imaging methods is expanding and allows quantitative assessment. The term molecular imaging is defined as the in vivo characterization and measurement of biologic processes at the cellular and molecular level. Molecular imaging sets forth to probe the molecular abnormalities that are the basis of disease rather than to visualize the end effects of these molecular alterations and, therefore, provides different additional biochemical or molecular information about primary brain tumors compared to histological methods "classical" neuroradiological diagnostic studies. Common clinical indications for molecular imaging contain primary brain tumor diagnosis and identification of the metabolically most active brain tumor reactions (differentiation of viable tumor tissue from necrosis), prediction of treatment response by measurement of tumor perfusion, or ischemia. The interesting key question remains not only whether the magnitude of biochemical alterations demonstrated by molecular imaging reveals prognostic value with respect to survival, but also whether it identifies early disease and differentiates benign from malignant lesions. Moreover, an early identification of treatment success or failure by molecular imaging could significantly influence patient management by providing more objective decision criteria for evaluation of specific therapeutic strategies. Specially, as molecular imaging represents a novel technology for visualizing metabolism and signal transduction to gene expression, reporter gene assays are used to trace the location and temporal level of expression of therapeutic and endogenous genes. Molecular imaging probes and drugs are being developed to image the function of targets without disturbing them and in mass amounts to modify the target's function as a drug. Molecular imaging helps to close the gap between in vitro and in vivo integrative biology of disease.

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Brain tumors: L-[1-C-11]tyrosine PET for visualization and quantification of protein synthesis rate.

Abstract: L-[1-C-11]-tyrosine is a valid tracer for diagnosis of brain tumors and allowed quantification of PSR.

Cited by 64 publications

References 0 publications

Tumor Cell Metabolism Imaging

Tumor Cell Metabolism Imaging

Non-natural amino acids for tumor imaging using positron emission tomography and single photon emission computed tomography

Molecular Imaging of Brain Tumors: A Bridge Between Clinical and Molecular Medicine?

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