Brain Tumors and Polyomaviruses

Croul, Sidney; Otte, Jessica; Khalili, Kamel

doi:10.1080/13550280390194055

Cited by 46 publications

(32 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, substantial attention has been given also to Polyomavirus oncoproteins, particularly large and small T antigens from Simian virus 40 (SV40), JC virus (JCV) and BK virus (BKV) (Croul et al, 2003;Helt and Galloway, 2003), owing to their expression in some specific human tumors, as pleural mesothelioma or tumors of the central nervous system (CNS).…”

Section: And References Therein)mentioning

confidence: 99%

“…Indeed, similarly to JCV, BKV infects a large percentage of individuals and becomes clinically evident mainly in immunodeficient or immunosuppressed patients (Wang et al, 2004). Equally, BKV DNA has been detected in human tumors, not only of the CNS but also of the pancreas and the urinary tract (Harris et al, 1998a;Croul et al, 2003;Fioriti et al, 2005). BK virus LT-Ag is composed of 695 amino acids and is structurally similar to SV40 and JCV LT-Ag (Figure 1).…”

Section: Bk Virus Large T-agmentioning

confidence: 99%

See 1 more Smart Citation

Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins

Mileo²,

2006

View full text Add to dashboard Cite

Section: And References Therein)mentioning

confidence: 99%

Section: Bk Virus Large T-agmentioning

confidence: 99%

Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins

Mileo²,

2006

View full text Add to dashboard Cite

“…The intracellular environment may permit the expression of early but not late gene of JCV not allowing the production of the complete virus. This may result in cell cycle dysregulation without cellular lysis leading to the expansion of these infected cells and their resulting transformation (Croul et al, 2003).…”

Section: Jcv Detection In Human Brain Tumorsmentioning

confidence: 99%

“…A regulatory region separates the coding regions and contains sequences that are necessary for the initiation of viral gene transcription and viral DNA replication. Transcription of the early and late genes proceeds in opposite directions around the viral DNA (Frisque and White, 1992;Bollag et al, 2000;Croul et al, 2003). The human JCV infects asymptomatically nearly 80% of human population.…”

Section: Human Polyomavirusesmentioning

confidence: 99%

“…Their genome consists of covalently bound, double-stranded, circular supercoiled DNA with an average length of 5 kb (Croul et al, 2003). All polyomaviral genomes have common structural features, which include an early region encoding for proteins involved in the regulation of viral replication, such as T-Ag, its isoforms and the small t antigen (t-Ag).…”

Section: Human Polyomavirusesmentioning

confidence: 99%

See 1 more Smart Citation

Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus

et al. 2006

View full text Add to dashboard Cite

Human polyomaviruses (JC virus, BK virus and simian virus 40) are causative agents of some human diseases and, interestingly, are involved in processes of cell transformation and oncogenesis. These viruses need the cell cycle machinery of the host cell to complete their replication; so they evolved mechanisms that can interfere with the growth control of infected cells and force them into DNA replication. The retinoblastoma family of proteins (pRb), which includes pRb/p105, p107 and pRb2/p130, acts as one of the most important regulators of the G1/S transition of the cell cycle. Rb proteins represent an important target for viral oncoproteins. Early viral T antigens can bind all members of the pRb family, promoting the activation of the E2F family of transcription factors, thus inducing the expression of genes required for the entry to the S phase.The interaction between early viral antigens and cell cycle regulators represents an important mechanism through which viruses deregulate cell cycle and lead to cell transformation. In this review, we will discuss the effects of the interaction between large T antigen and Rb proteins in JC virusmediated oncogenesis.

show abstract

Central nervous system tumours in children: Epidemiology and risk factors

McKinney

2005

Bioelectromagnetics

View full text Add to dashboard Cite

In children, a variety of distinct tumour types arise in the central nervous system (CNS) but they are frequently considered by epidemiologists as a single entity. CNS tumours are the second most common childhood malignancy and occur more frequently in developed countries than developing nations. Approximately 50% of paediatric CNS tumours are gliomas, with astrocytomas of the piloctyic type predominating. Distributions of subtypes by age show that primitive neuroectodermal tumours (PNET) and ependymomas mainly occur in children less than 10 years. There is an ongoing debate with regard to the apparent increases in incidence over recent decades, which, it has been suggested, are accounted for by improved diagnostic technologies implemented in the mid 1980s. CNS tumours differ between children and adults with respect to the proportion of all cancers (20% in children, less than 2% in adults), their cellular origins, classification scheme, the proportions of pathological subtypes, and anatomic site. The causes of childhood CNS tumours are largely unknown; and although an estimated 5% or more may be explained by genetic predisposition, investigations of environmental aetiology have not been fruitful. Whilst high dose ionising radiation is an established risk factor for this group of tumours, reported associations with dietary N-nitroso compounds have not been consistent. Exposure to ELF EMF, at any level, has not been associated with childhood CNS tumours, but the current evidence base is inadequate for complete evaluation. The rarity of childhood CNS tumours necessitates careful attention being paid to the design of future aetiological studies.

show abstract

Brain Tumors and Polyomaviruses

Abstract: Polyomaviruses, including JC virus (JCV), BK virus (BKV),

Cited by 46 publications

References 72 publications

Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins

Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins

Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus

Central nervous system tumours in children: Epidemiology and risk factors

Contact Info

Product

Resources

About