Brain tissue pulsatility mediates cognitive and electrophysiological changes in normal aging: Evidence from ultrasound tissue pulsatility imaging (TPI)

Angel, Lucie; Bouazzaoui, Badiâa; Isingrini, Michel; Fay, Séverine; Taconnat, Laurence; Vanneste, Sandrine; Ledoux, Moïse; Gissot, Valérie; Hommet, Caroline; Andersson, Frédéric; Barantin, Laurent; Cottier, Jean‐Philippe; Pasco, Jeremy; Desmidt, Thomas; Patat, F.; Camus, Vincent; Remeniéras, Jean-Pierre

doi:10.1016/j.bandc.2018.02.001

Cited by 11 publications

(17 citation statements)

References 37 publications

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“…The remaining 10 relevant records comprised nine peer-reviewed original publications [11][12][13][14][15][16][17][18][19] and one conference proceeding. 20 The conference proceeding on 2D speckle tracking was included as we found no associated peer-reviewed article.…”

Section: Resultsmentioning

confidence: 99%

“…16 This is of interest as WMH has also been found to be associated with pathological conditions (such as cognitive impairment and depression). 16 Recently, Angel et al 17 studied the relationship between age, cognitive function, and brain tissue pulsatility using TPI in healthy subjects. This study of 39 subjects found that pulsatility decreased with age and was positively correlated with fluid intelligence (such as novel problem solving) measures.…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…This study of 39 subjects found that pulsatility decreased with age and was positively correlated with fluid intelligence (such as novel problem solving) measures. 17 The latest TPI study was in 2018; Desmidt et al 18 assessed the association between different brain volumes (measured by MRI) and brain pulsatility. TPI was used to estimate tissue pulsatility in 25 healthy, middle-aged females.…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…Across all of the records, a total of 216 individuals were investigated. Five studies only recruited healthy participants, 11,12,[16][17][18] whilst two recruited patients with depression, 13,15 and another recruited participants over 80 years of age with orthostatic hypertension. 14 Two technical feasibility studies 19,20 did not describe the characteristics of their participants.…”

Section: Study Populationsmentioning

confidence: 99%

“…11,12 Others compared properties between control and non-control populations. [13][14][15]17 Some of the studies compared TPI measurements with results from other modalities such as MRI or TCD blood flow estimates. 16,18 Study technical information Despite most of the studies using TPI, there were wide variations in technical setups, including different ultrasound probes, acquisition points, and participant posture.…”

Section: Study Populationsmentioning

confidence: 99%

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Ultrasound measurement of brain tissue movement in humans: A systematic review

et al. 2019

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Introduction It has long been suggested that ultrasound could be used to measure brain tissue pulsations in humans, but potential clinical applications are relatively unexplored. The aim of this systematic review was to explore and synthesise available literature on ultrasound measurement of brain tissue motion in humans. Methods Our systematic review was designed to include predefined study selection criteria, quality evaluation, and a data extraction pro-forma, registered prospectively on PROSPERO (CRD42018114117). The systematic review was conducted by two independent reviewers. Results Ten studies were eligible for the evidence synthesis and qualitative evaluation. All eligible studies confirmed that brain tissue motion over the cardiac cycle could be measured using ultrasound; however, data acquisition, analysis, and outcomes varied. The majority of studies used tissue pulsatility imaging, with the right temporal window as the acquisition point. Currently available literature is largely exploratory, with measurements of brain tissue displacement over a narrow range of health conditions and ages. Explored health conditions include orthostatic hypotension and depression. Conclusion Further studies are needed to assess variability in brain tissue motion estimates across larger cohorts of healthy subjects and in patients with various medical conditions. This would be important for informing sample size estimates to ensure future studies are appropriately powered. Future research would also benefit from a consistent framework for data analysis and reporting, to facilitate comparative research and meta-analysis. Following standardisation and further healthy participant studies, future work should focus on assessing the clinical utility of brain tissue pulsation measurements in cerebrovascular disease states.

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Section: Resultsmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Study Populationsmentioning

confidence: 99%

Section: Study Populationsmentioning

confidence: 99%

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Ultrasound measurement of brain tissue movement in humans: A systematic review

et al. 2019

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Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study

Siragusa

Rufin

Courtois

et al. 2020

Brain Imaging and Behavior

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Changes in the Brain Connectome With Age

Eggermont¹

2019

The Auditory Brain and Age-Related Hearing Impairment

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Brain tissue pulsatility mediates cognitive and electrophysiological changes in normal aging: Evidence from ultrasound tissue pulsatility imaging (TPI)

Cited by 11 publications

References 37 publications

Ultrasound measurement of brain tissue movement in humans: A systematic review

Ultrasound measurement of brain tissue movement in humans: A systematic review

Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study

Changes in the Brain Connectome With Age

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